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Postion:Product Catalog >API>Antiparasitic drugs>Anthelmintic>Arecoline hydrobromide
Arecoline hydrobromide
  • Arecoline hydrobromide

Arecoline hydrobromide NEW

Price Get Latest Price
Package 1kg 25kg
Min. Order: 1kg
Supply Ability: 300KG/Month
Update Time: 2024-05-28

Product Details

Product Name: Arecoline hydrobromide CAS No.: 300-08-3
EC-No.: 206-087-3 Min. Order: 1kg
Purity: 99% Supply Ability: 300KG/Month
Release date: 2024/05/28

Arecoline hydrobromide

CAS: 300-08-3

Molecular Formula: C8H14BrNO2

NameArecoline hydrobromide
Synonymsarecane
Arecoline HBr
arecolinebromide
arekolinhydrobromid
Arecoline hydrobromide
ARECOLINE HYDROBROMIDE CRYSTALLINE
ARECOLIN HYDROBROMIDE VETRANAL, 250
ARECOLINE HYDROBROMIDE CHOLINERGIC AGONI ST
methyl 1,2,5,6-tetrahydro-1-methyl-3-pyridinecarboxylate hydrobromide
1-Methyl-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid methyl ester hydrobromide
3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-methyl-, methyl ester, hydrobromide
CAS300-08-3
EINECS206-087-3
InChIInChI=1/C8H13NO2.BrH/c1-9-5-3-4-7(6-9)8(10)11-2;/h4H,3,5-6H2,1-2H3;1H
InChIKeyAXOJRQLKMVSHHZ-UHFFFAOYSA-N

300-08-3 - Physico-chemical Properties

Molecular FormulaC8H14BrNO2
Molar Mass236.11
Melting Point171-175°C
Boling Point209°C at 760 mmHg
Flash Point81.1°C
SolubilityH2O: 0.1g/mL, clear, colorless
Vapor Presure0.208mmHg at 25°C
AppearancePowder
ColorWhite to light yellow
Merck14,778
BRN3914826
pKa6.84(at 25℃)
Storage ConditionInert atmosphere,Room Temperature
StabilityStable for 2 years from date of purchase as supplied. Solutions are not stable – make fresh daily.
Physical and Chemical PropertiesThis product is white or light yellow crystalline powder; Odorless, bitter taste. It is soluble in water and ethanol, slightly soluble in chloroform and ether, and the aqueous solution is relatively stable. It should be stored in a container protected from light.

300-08-3 - Risk and Safety

Risk CodesR22 - Harmful if swallowed
R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed.
Safety DescriptionS45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S38 - In case of insufficient ventilation, wear suitable respiratory equipment.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S28A -
UN IDs1544
WGK Germany3
RTECSQT2275000
FLUKA BRAND F CODES8
HS Code29399990
Hazard Class6.1
Packing GroupIII
ToxicityLD50 par-rat: 270 mg/kg ABMGAJ 28,681,72

300-08-3 - Reference Information

EPA chemical informationInformation provided by: ofmpub.epa.gov (external link)
OverviewArecoline is an alkaloid in the seeds of the plant areca nut, and its hydrobromide is commonly used clinically [1]. White crystalline powder, odorless, bitter, poisonous, deteriorated in case of light. Melting point 170- 171 ℃. Soluble in water and ethanol. It is obtained by the reaction of arecoline with hydrobromic acid ethanol solution. Intestinal insect repellent drugs are mostly used for veterinary treatment [2].

figure 1 arecoline hydrobromide tablets
research on antithrombotic effectresearch on antithrombotic and thrombolytic effects of arecoline hydrobromide on thrombus in vivo and in vitro. Methods: The thrombolytic effect of arecoline hydrobromide in vitro was investigated by the dissolution of human blood clots and human platelet plasma clots in vitro.

The anti-thrombotic effect of arecoline hydrobromide in vivo was investigated by the model of carrageenan-induced tail vein thrombosis in mice. Results: Arecoline hydrobromide can accelerate the dissolution of human blood clots and platelet plasma clots in vitro, and has a dose-dependent effect of

; it has the effect of anti-carrageenan-induced tail vein thrombosis in mice. Conclusion: Hydrobromic acid

arecoline has antithrombotic effect in vivo and in vitro.
pharmacological actionarecoline hydrobromide has a strong paralyzing effect on tapeworm muscles, causing the worm body to lose the ability to cling to the intestinal wall. in addition, the muscarinic effect of the drug on the host strengthens intestinal peristalsis and increases secretion of digestive glands, which is conducive to the rapid elimination of paralytic worms.
This product is effective for all tapeworms in dogs. It can also repel taenia, polycephalus and Echinococcus granulosus. It also has an repellent effect on avian tapeworms.
clinical applicationis mainly used for taeniasis common in dogs and poultry.
usage and dosageoral administration: one dose, per kilogram of body weight, 1.5-2 mg for dogs, 3 mg for chickens, 1-2 mg for ducks and geese.
adverse reactions and poisoning rescue(1) the use of normal dose of arecoline hydrobromide has less adverse reactions to dogs, and vomiting, diarrhea, secondary coma and convulsion can obviously occur when overdose. The general poisoning dose can be as much as 8 times the therapeutic dose.
(2) This product is not safe for cats, and it can make their bronchi secrete a large amount of mucus and cause cats to suffocate and die.
(3) atropine can detoxify and relieve symptoms of this product.
precautions(1) dogs should fast for 12 hours before medication. if they still do not defecate 2 hours after medication, they should be taken with saline to accelerate the elimination of paralysis.
(2) chickens have strong tolerance to this product, followed by ducks and geese, equine animals are more sensitive, and cats are the most sensitive, so it is advisable not to use it.
(3) Due to the high toxicity of this product, it has been banned in the United States.
drug combinationatropine: it can detoxify arecoline and relieve symptoms, and can be used to rescue arecoline poisoning.
Choline-like drugs such as pilocarpine: the combination of the two can enhance the toxicity.
Pumpkin seeds: The combination of arecoline and pumpkin seeds can repel naked head tapeworm.
References[1] Wang Kunhua, edited by Yang Zhikang. Guidelines for rational clinical application of veterinary drugs. Kunming: Yunnan Science and Technology Press. 2010.
[2] Ma Shichang editor-in-chief. Dictionary of organic compounds. Xi'an: Shaanxi Science and Technology Press. 1988. Page 284.
[3] Tang Fei, Wang Hao, Liu Weijun. Study on antithrombotic effect of arecoline hydrobromide [J]. Chinese Journal of Hospital Pharmacy, 2009,29(10):791-793.
usefor content determination/identification/pharmacological experiments, etc.
categorytoxic substances
toxicity classificationhighly toxic
acute toxicitysubcutaneous-mouse LDL0: 65 mg/kg; Intravenous-mouse LD50: 18 mg/kg
flammability hazard characteristicscombustible; combustion produces toxic nitrogen oxides and hydrogen bromide smoke
storage and transportation characteristicswarehouse ventilation and low temperature drying; separate from food raw materials
fire extinguishing agentdry powder, foam, sand, carbon dioxide, mist water

Article illustrationArticle illustrationArticle illustration

1.who are we?
Shijiazhuang Jianxin Biotechnology Co., LTD

2. how can we guarantee quality?
Always a pre-production sample before mass production;
Always final Inspection before shipment;

3.what can you buy from us?
2-phenylacetamide
Tryptamine PMK ethyl glycidate etc.

4. why should you buy from us not from other suppliers?
Product quality is good, the staff through professional training, good after-sales, fast logistics, transportation safety.

5. what services can we provide?
Accepted Delivery Terms: FOB,CFR,CIF,EXW,FCA,DDP,Express Delivery
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Company Profile Introduction

Shijiazhuang Jianxin Biotechnology Co., Ltd., located in Xingtang Economic Development Zone, Shijiazhuang City, Hebei Province, is a comprehensive enterprise engaged in the procurement, research and development, production, sales, and import and export trade of functional electrolyte additives, pesticide intermediates, pharmaceutical intermediates, fluorine-containing chemicals, liquid crystal materials, OLED materials, and special functional monomers. It ranks among the top in the domestic and international market share in related fields. The company has a 400㎡ R&D center, a first-class professional technical team, and is equipped with synthesis equipment and advanced analytical testing instruments that meet different reaction conditions. Through continuous development of more advanced new material processes, the company has production capabilities ranging from gram level to kilogram level laboratories, Chinese style workshops, and ton level production bases, which can achieve industrialization of products with different reaction needs. Shijiazhuang Jianxin Biotechnology Co., Ltd. has a sound quality inspection institution and quality assurance system. The company always regards quality as life, service as leadership, and reputation as its purpose. We sell our products to China, Europe, the United States, Japan, South Korea and other places at reasonable prices, covering the global electrolyte additive industry, pharmaceutical, pesticide and other industries. In the future, Jianxin Biotechnology will further strengthen the efficiency of new product research and industrialization, enhance the company's core competitiveness, and strive to build the company into a world advanced chemical material manufacturer.

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Shijiazhuang Jianxin Biotechnology Co., LTD

1YR ChinaChina
  • Since: 2023-11-27
  • Address: No.17, Xinglong West Street, North Longgang Village, Nanqiao Town, Xingtang County, Shijiazhuang Cit
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