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Postion:Product Catalog >Biochemical Engineering>Amino Acids and Derivatives>Other amino acid derivatives>DMOG
DMOG
  • DMOG

DMOG

Price $5
Package 5KG
Min. Order: 1KG
Supply Ability: 1ton
Update Time: 2019-09-04

Product Details

Product Name: DMOG CAS No.: 89464-63-1
EC-No.: 200-256-5 Min. Order: 1KG
Purity: 99% Supply Ability: 1ton
Release date: 2019/09/04
contact person: Flora
DMOG Basic information
Product Name:
DMOG
Synonyms:
N-(METHOXYOXOACETYL)-GLYCINE METHYL ESTER;DIMETHYLOXALLYL GLYCINE;HIF-Hydroxylase Inhibitor, DMOG - CAS 89464-63-1 - Calbiochem;DIMETHYLOXALYLGLYCINE;DMOG;Dimethyloxaloylglycine;N-[(Methoxycarbonyl)Methyl]oxaMic Acid Methyl Ester;DiMethyloxaloylglycine (DMOG)
CAS:
89464-63-1
MF:
C6H9NO5
MW:
175.14
EINECS:
 
Product Categories:
Bio-material;NONE;Other;Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives;Inhibitors
Mol File:
89464-63-1.mol
Article illustration
 
DMOG Chemical Properties
Melting point 
46-48°C
storage temp. 
Refrigerator
solubility 
H2O: >30mg/mL
form 
Solid
color 
white to off-white
Water Solubility 
Soluble in water at 30mg/ml.
 
Safety Information
Hazard Codes 
Xi,Xn
Risk Statements 
22
WGK Germany 
3
HazardClass 
IRRITANT
MSDS Information
 
 
DMOG Usage And Synthesis
Chemical Properties
Off-White to Pale Pink Solid
Uses
DMOG is a cell permeable prolyl-4-hydroxylase inhibitor which upregulates HIF activity. HIF activation stimulates angiogenesis in several different models (1nM). DMOG also inhibits FIH (factor inhibiting HIF), an asparaginyl hydroxylase, which enhances the HIF response. It is active in vivo and attenuates myocardial injury in a rabbit ischemia reperfusion model (20mg/Kg).
Enzyme inhibitor
This iron-binding a-ketoglutarate (2-oxoglutarate) analogue (FW = 147.09 g/mol; also named N-oxaloglycine) competitively inhibits prolyl-4- hydroxylase (Reaction: Procollagen (L-proline) + a-ketoglutarate + O2 → Procollagen ( (2S,4R) -4-hydroxyproline) + succinate + CO2). During catalysis, prolyl-4-hydroxylase forms Fe (III), and the latter most likely makes an extremely stable metal ion complex with N-oxaloglycine. Substitution on the glycine moiety alters inhibitor activity stereoselectively and that, if the w-carboxylate is homologated or replaced, either by acylsulfonamides or anilide, activity is likewise sharply reduced. Prolyl- 4-Hydroxylase Catalysis: Each catalytic round of this posttranslational modifying enzyme reaction occurs in two stages. O2 is bound end-on in an axial position, producing a dioxygen unit. Nucleophilic attack at C-2 generates a tetrahedral intermediate, with loss of the double bond in dioxygen and bonds to iron and the a-carbon of a-ketoglutarate. Elimination of CO2 coincides with formation of the Fe (IV) =O species. The second stage involves the abstraction of the pro-R hydrogen atom from C-4 of proline, followed by radical combination, yielding hydroxyproline. In the presence of a-ketoglutarate, enzyme-bound Fe2+ is rapidly converted to Fe3+, resulting in inactivation of the enzyme Ascorbate is utilized as a cofactor to reduce Fe (III) back to Fe (II). Cell-Permeable Analogue: Dimethyloxalylglycine (FW = 175.14 g/mol; CAS 89464-63-1; Symbol: DMOG, also named N- (methoxyoxoacetyl) -glycine methyl ester) is metabolicaly demethylated to form N-oxaloglycine upon entry to many cells.
 
DMOG Preparation Products And Raw materials

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates: Pharmaceutical intermediates; OLED intermediates;

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