Necrostatin-1
Price | $5 |
Package | 5KG |
Min. Order: | 1KG |
Supply Ability: | 1ton |
Update Time: | 2019-09-04 |
Product Details
Product Name: Necrostatin-1 | CAS No.: 4311-88-0 |
EC-No.: 200-256-5 | Min. Order: 1KG |
Purity: 99% | Supply Ability: 1ton |
Release date: 2019/09/04 | |
contact person: Flora |
▼
▲
Necrostatin-1 Basic information
Description Features In vitro
▼
▲
Product Name:
Necrostatin-1
Synonyms:
Necrostatin-1 - CAS 4311-88-0 - Calbiochem;IFLAB-BB F0911-6127;5-(1H-INDOL-3-YLMETHYL)-3-METHYL-2-THIOXO-4-IMIDAZOLIDINONE;5-(INDOL-3-YLMETHYL)-3-METHYL-2-THIO-HYDANTOIN;NECROSTATIN-1;MTH-DL-TRYPTOPHAN;MTH-DL-Tryptophan Methylthiohydantoin-DL-tryptophan;5-(1H-Indole-3ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone
CAS:
4311-88-0
MF:
C13H13N3OS
MW:
259.33
EINECS:
Product Categories:
Miscellaneous Signaling;Apoptosis Inhibitors;Inhibitors;Inhibitor
Mol File:
4311-88-0.mol
▼
▲
Necrostatin-1 Chemical Properties
▼
▲
Melting point
151℃
density
1.40±0.1 g/cm3 (20 ºC 760 Torr)
Fp
93.3℃
storage temp.
−20°C
solubility
DMSO: >10 mg/mL
form
solid
Sensitive
Light Sensitive
▼
▲
Safety Information
▼
▲
Risk Statements
36/37/39
Safety Statements
36/37/39
WGK Germany
3
HS Code
29339900
▼
▲
MSDS Information
▼
▲
SigmaAldrich
English
▼
▲
Necrostatin-1 Usage And Synthesis
▼
▲
Description
Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM in 293T cells.
Features
A powerful tool for characterizing the role of necroptosis with characterized primary target.
In vitro
Necrostatin-1 (1-100 μM) inhibits the autophosphorylation of overexpressed and endogenous RIP1.It is found RIP1 is the primary cellular target responsible for the antinecroptosis activity of Necrostatin-1. Necrostatin-1 efficiently suppresses necroptotic cell death triggered by an array of stimuli in a variety of cell types. Necrostatin-1, previously identified as small-molecule inhibitor of necroptosis, inhibits RIP kinase-induced necroptosis and inhibits TNF-α-induced necroptosis in jurkat cells with EC50 of 490 nM.
Uses
Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM.
Uses
Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Necrostatin-1 is an inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells. Necrostatin-1 has been used to investigate the pathological importance of necroptosis in ischemic brain injury and myocardial infarction.
Biological Activity
ATP-competitive death domain receptor-associated adaptor kinase (RIP1) allosteric inhibitor (EC 50 = 182 nM). Blocks non-apoptotic cell death via inhibition of a specific cellular pathway, necroptosis, which leads to necrosis (EC 50 = 494 nM). Reduces ischemic brain injury in a mouse model of stroke.
▼
▲
Necrostatin-1 Preparation Products And Raw materials
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates:
Pharmaceutical intermediates;
OLED intermediates;
You may like
Recommended supplier
Product name | Price | Suppliers | Update time | |
---|---|---|---|---|
$30.00/5mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-15 | |
$48.00/1mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-14 | |
$119.00/2mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-10-28 | |
$0.00/1kg |
VIP2Y
|
Nanjing Fred Technology Co., Ltd
|
2023-12-29 |
- Since: 2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
INQUIRY
楊俊青
sales@coreychem.com
sales@coreychem.com