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Postion:Product Catalog >Biochemical Engineering>Inhibitors>Apoptosis>TNF-alpha inhibitors>Necrostatin-1
Necrostatin-1
  • Necrostatin-1

Necrostatin-1

Price $5
Package 5KG
Min. Order: 1KG
Supply Ability: 1ton
Update Time: 2019-09-04

Product Details

Product Name: Necrostatin-1 CAS No.: 4311-88-0
EC-No.: 200-256-5 Min. Order: 1KG
Purity: 99% Supply Ability: 1ton
Release date: 2019/09/04
contact person: Flora
Necrostatin-1 Basic information
Description Features In vitro
Product Name:
Necrostatin-1
Synonyms:
Necrostatin-1 - CAS 4311-88-0 - Calbiochem;IFLAB-BB F0911-6127;5-(1H-INDOL-3-YLMETHYL)-3-METHYL-2-THIOXO-4-IMIDAZOLIDINONE;5-(INDOL-3-YLMETHYL)-3-METHYL-2-THIO-HYDANTOIN;NECROSTATIN-1;MTH-DL-TRYPTOPHAN;MTH-DL-Tryptophan Methylthiohydantoin-DL-tryptophan;5-(1H-Indole-3ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone
CAS:
4311-88-0
MF:
C13H13N3OS
MW:
259.33
EINECS:
 
Product Categories:
Miscellaneous Signaling;Apoptosis Inhibitors;Inhibitors;Inhibitor
Mol File:
4311-88-0.mol
Article illustration
 
Necrostatin-1 Chemical Properties
Melting point 
151℃
density 
1.40±0.1 g/cm3 (20 ºC 760 Torr)
Fp 
93.3℃
storage temp. 
−20°C
solubility 
DMSO: >10 mg/mL
form 
solid
Sensitive 
Light Sensitive
 
Safety Information
Risk Statements 
36/37/39
Safety Statements 
36/37/39
WGK Germany 
3
HS Code 
29339900
MSDS Information
Provider Language
SigmaAldrich
English
 
Necrostatin-1 Usage And Synthesis
Description
Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM in 293T cells.
Features
A powerful tool for characterizing the role of necroptosis with characterized primary target.
In vitro
Necrostatin-1 (1-100 μM) inhibits the autophosphorylation of overexpressed and endogenous RIP1.It is found RIP1 is the primary cellular target responsible for the antinecroptosis activity of Necrostatin-1. Necrostatin-1 efficiently suppresses necroptotic cell death triggered by an array of stimuli in a variety of cell types. Necrostatin-1, previously identified as small-molecule inhibitor of necroptosis, inhibits RIP kinase-induced necroptosis and inhibits TNF-α-induced necroptosis in jurkat cells with EC50 of 490 nM.
Uses
Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM.
Uses
Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Necrostatin-1 is an inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells. Necrostatin-1 has been used to investigate the pathological importance of necroptosis in ischemic brain injury and myocardial infarction.
Biological Activity
ATP-competitive death domain receptor-associated adaptor kinase (RIP1) allosteric inhibitor (EC 50 = 182 nM). Blocks non-apoptotic cell death via inhibition of a specific cellular pathway, necroptosis, which leads to necrosis (EC 50 = 494 nM). Reduces ischemic brain injury in a mouse model of stroke.
 
Necrostatin-1 Preparation Products And Raw materials

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates: Pharmaceutical intermediates; OLED intermediates;

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