What is 5-Bromo-2-methoxy-3-methylpyridine?

5-Bromo-2-methoxy-3-methylpyridine is an organic compound belonging to the class of halogenated pyridines. It is a derivative of pyridine, a six-membered aromatic ring with one nitrogen atom, where the 5-position is substituted with a bromine atom, the 2-position with a methoxy group (-OCH3), and the 3-position with a methyl group (-CH3).

Chemical Structure and Properties

• Chemical Formula: C7H8BrNO

• Molecular Weight: Approximately 202.05 g/mol

• Structure:

• Pyridine ring with a bromine atom at the 5-position.

• A methoxy group (-OCH3) at the 2-position.

• A methyl group (-CH3) at the 3-position.

• Appearance: Typically, it is a colorless to pale yellow liquid or crystalline solid.

• Solubility: It is soluble in organic solvents like ethanol, methanol, and dichloromethane.

• Stability: Generally stable under normal conditions but should be kept away from strong oxidizing agents.

Applications of 5-Bromo-2-methoxy-3-methylpyridine

1. Pharmaceutical Intermediates

• Application: Used as an intermediate in the synthesis of pharmaceutical compounds. The bromine atom makes it a versatile building block for various organic reactions, such as cross-coupling reactions.

• Benefits: Allows for the introduction of complex functionalities into pharmaceutical molecules, which can be critical for drug design and development.

2. Organic Synthesis

• Application: Employed in the synthesis of other heterocyclic compounds. The presence of the bromine atom facilitates substitution reactions, and the methoxy and methyl groups can be further modified.

• Benefits: Serves as a useful starting material or intermediate in the preparation of a wide range of chemical compounds.

3. Agrochemicals

• Application: It may be used in the development of agrochemicals, such as herbicides or insecticides, where pyridine derivatives often play a role.

• Benefits: The compound’s structure can be optimized for biological activity against pests or weeds.

Safety and Handling

• Toxicity: While specific toxicity data may vary, compounds like 5-Bromo-2-methoxy-3-methylpyridine should be handled with care. Avoid inhalation, ingestion, and skin contact, and use appropriate personal protective equipment (PPE).

• Environmental Impact: Disposal should follow local regulations, particularly since halogenated compounds can have environmental impacts if not properly managed.

Summary

5-Bromo-2-methoxy-3-methylpyridine is a halogenated pyridine derivative used primarily as an intermediate in pharmaceutical synthesis, organic chemistry, and potentially in agrochemicals. Its reactivity, due to the bromine atom, and its substituted pyridine ring make it a versatile compound in various chemical applications. Proper handling and disposal are essential to ensure safety and minimize environmental impact.

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