2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid, commonly known as sulisobenzone, is an organic compound that is widely used as an active ingredient in sunscreens and other personal care products. Here’s a breakdown of its key aspects:

Chemical Properties:

• Chemical Formula: C14H12O6S

• Molecular Structure: It is a benzophenone derivative with hydroxyl, methoxy, and sulfonic acid groups attached to the benzene rings.

Applications:

• Sunscreen Agent: Sulisobenzone is primarily used as a UV filter in sunscreens. It absorbs ultraviolet (UV) light, particularly in the UVB range (290-320 nm), and to a lesser extent in the UVA range (320-400 nm), helping to protect the skin from harmful effects of sun exposure, such as sunburn and long-term damage like skin cancer and premature aging.

• Cosmetic Products: Beyond sunscreens, sulisobenzone can be found in a variety of personal care products, including lotions, moisturizers, and lip balms that offer sun protection.

• Photostabilizer: In addition to its UV-absorbing properties, sulisobenzone can act as a photostabilizer, meaning it helps to stabilize other ingredients in a formulation that might otherwise degrade upon exposure to sunlight.

Safety and Regulation:

• Safety Profile: Sulisobenzone is generally considered safe for use in cosmetics and sunscreens when used within the concentration limits set by regulatory agencies. However, like other chemical sunscreens, it can sometimes cause skin irritation or allergic reactions in sensitive individuals.

• Regulatory Status: It is approved for use in sunscreens and cosmetic products by various regulatory bodies around the world, though the allowable concentrations can vary by region. In the United States, for example, the Food and Drug Administration (FDA) allows its use in concentrations up to 10% in sunscreen products.

Mechanism of Action:

• Sulisobenzone works by absorbing UV radiation and dissipating it as heat, preventing it from penetrating the skin and causing cellular damage. This makes it an effective ingredient for broad-spectrum sun protection.

In summary, 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid (sulisobenzone) is a key ingredient in many sunscreens and cosmetic products, valued for its ability to protect the skin from harmful UV rays and stabilize other ingredients in formulations exposed to sunlight.

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