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Postion:Product Catalog >Pharmaceutical intermediates>Bulk Drug Intermediates>Vonoprazan Fumarate
Vonoprazan Fumarate
  • Vonoprazan Fumarate
  • Vonoprazan Fumarate
  • Vonoprazan Fumarate
  • Vonoprazan Fumarate
  • Vonoprazan Fumarate

Vonoprazan Fumarate

Price Get Latest Price
Package 25KG
Min. Order: 2KG
Supply Ability: 20tons
Update Time: 2024-11-01

Product Details

Product Name: Vonoprazan Fumarate CAS No.: 1260141-27-2
Min. Order: 2KG Purity: 99% min/GMP/PMDA/DMF
Supply Ability: 20tons Release date: 2024/11/01

Product Information

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COA of Vonoprazan Fumarate

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Usage

Function of Vonoprazan Fumarate
1) Prevention of duodenal ulcer and gastric ulcer recurrence

A randomized, double-blind, multi-center clinical phase 3 trial comparing the effects of Voronazan fumarate (10mgqd and 20mgqd) and lansoprazole (15mgqd) on nonsteroidal anti-inflammatory drug-related peptic ulcer A total of 642 patients had been diagnosed with endoscopic peptic ulcers and needed to take non-steroidal anti-inflammatory drugs. The treatment period was 24 weeks. The primary endpoint was the proportion of duodenal ulcer and gastric ulcer recurrence at 24 weeks.

2) Corrosive esophagitis (erosiveoesophagitis, EO)

In a randomized, double-blind, multi-center, dose-range clinical phase 2 trial, in patients with EO, compared with lansoprazole, Voronazan fumarate showed non-inferiority and was rated in Los Angeles as C/D grade patients showed excellent effects, and oral administration of 20 mg once daily became the clinically recommended dose for the treatment of EO. A randomized, double-blind, multi-center clinical phase 3 trial comparing the efficacy of this product (20mgqd) and lansoprazole (30mgqd) on EO, a total of 409 patients participated in the study.

3) Helicobacter pylori infection (Helicobacterpylori, Hp)

A randomized, double-blind, multi-center clinical phase 3 trial comparing vonolazan fumarate (20mgbid) and lansoprazole (30mgbid), combined with amoxicillin and clarithromycin, to form a triple therapy, The effect of first-line medicine to eradicate Hp was included in a total of 650 Hp-positive patients who had had gastric ulcer or duodenal ulcer. The Hp eradication rates of this product and lansoprazole in the test group were 92.6% and 75.9%, respectively. For patients with clarithromycin resistance, the Hp eradication rates in the two test groups were 82.0% and 40.0%, respectively. Significantly superior to lansoprazole. In this trial, the first 50 patients who failed first-line treatment received second-line treatment with triple therapy of this product, amoxicillin and metronidazole, and the Hp clearance rate was 98%.


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Company Profile Introduction

Sinoway Industrial co., ltd. was established in 1987 in Xiamen, China, and now has been a leading group specialized in research, development, custom manufacturing and trading of pharmaceutical intermediates, APIs, health and food supplements, cosmetic raw materials, herbal extracts, polypeptides and prostaglandin derivatives, etc.. We have passed ISO9001:2015. With qualified products, competitive price and excellent service, we have received great reputation of our customers from all over the world, including Southeast Asia, Europe, North America, South America, Middle East and other countries. We have over 20 years good partners in Japan、Korea and Switzerland. Sinoway has a professional R&D team. We have built close cooperative relationships with many research institutes and universities in China. Moreover, Sinoway combines market analysis with technology, providing new business trends to our clients. In addition, we have very close cooperation relationships with many Chinese pharmaceutical factories. These pharmaceutical manufacturers have GMP regulated workshops, advanced production and testing equipments, first-class QC labs and a production team with rich experience. We can supply various Active Pharmaceutical Ingredients and finished products which meet EP/USP/BP standards. Chinese GMP, EU-GMP, COS/CEP certificates with DMF documents are available, and many products have been approved by FDA. We believe that quality and innovation are vital for an enterprise. Adhering to the business philosophy of integrity and win-win cooperation, Sinoway is looking forward to have a bright future with you together.

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