促食素A
| 中文名稱 | 促食素A |
|---|---|
| 中文同義詞 | 下視丘分泌素;增食欲素A/欲激素A抗體;阿立新A;促食素A;食欲素A(牛,人類,小鼠,大鼠);GLP-PRO-LEU-PRO-ASP-CYS-CYS-ARG-GLN-LYS-THR-CYS-SER-CYS-ARG-LEU-TYR-GLU-LEU-LEU-HIS-GLY-ALA-GLY-ASN-HIS-ALA-ALA-GLY-IIE-LEU-THR-LEU-NH2 (DISULFIDE BRIDGE: CYS6-CYS12, CYS7-CYS14);食欲素A;ANTI-OREXIN A ANTIBODY-增食欲素A/欲激素A抗體 |
| 英文名稱 | Orexin A (bovine, human, mouse, rat) |
| 英文同義詞 | OREXIN A (HUMAN, RAT, MOUSE);OREXIN-A (HUMAN) (RAT, MOUSE, BOVINE);OREXIN A (HUMAN, BOVINE, MOUSE, RAT);OREXIN A (HUMAN, BOVINE, RAT, MOUSE);PGLU-PRO-LEU-PRO-ASP-CYS-CYS-ARG-GLN-LYS-THR-CYS-SER-CYS-ARG-LEU-TYR-GLU-LEU-LEU-HIS-GLY-ALA-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-LEU-NH2;HYPOCRETIN;OREXIN A (HUMAN, BOVINE, CANINE, MOUSE, OVINE, PORCINE, RAT);Hypocretin 1 |
| CAS號 | 205640-90-0 |
| 分子式 | C152H243N47O44S4 |
| 分子量 | 3561.1 |
| EINECS號 | |
| 相關類別 | 多肽;多肽-客戶肽;定制多肽;試劑盒-細胞分析試劑盒;試劑盒-Elisa試劑盒;標準品;原料藥;目錄肽;醫(yī)用原料;目錄多肽;食品添加劑;Peptide Receptors;hormones;Peptide;Orexin receptor |
| Mol文件 | 205640-90-0.mol |
| 結構式 |  |
促食素A 性質
| 密度 | 1.53±0.1 g/cm3(Predicted) |
|---|---|
| 儲存條件 | -15°C |
| 溶解度 | 無菌條件下溶解度為 1 mg/ml |
| 形態(tài) | 結晶固體 |
| 顏色 | 白色至米白色 |
| 水溶解性 | Soluble in water at 1mg/ml |
| 序列 | Glp-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-IIE-Leu-Thr-Leu-NH2 (Disulfide bridge: Cys6-Cys12, Cys7-Cys14) |
Orexin A human, rat, mouse 是一種 33 氨基酸興奮性神經(jīng)肽，參與多種中樞和外周過程。Orexin A human, rat, mouse 是一種特異性、高親和力的 G 蛋白偶聯(lián)受體 OX1R 激動劑，在調節(jié)攝食行為中起重要作用。Orexin A human, rat, mouse 是一種有效的抗傷害和抗痛覺過敏的藥物。
純度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
內毒素≤50EU/mg
氨基酸組成分析≤±10%
Orexin A human, rat, mouse has high affinity for OX1R, with 38 nM IC 50 and 34 nM EC 50 values in the the [Ca 2﹢ ]i transient assay.
Orexin A human, rat, mouse (3-30 mg/kg; i.v.; 5 min pre-test) significantly increases the latency to response at 10 and 30 mg/kg i.v. when given 5 min pre-test from 24.8±2.0 s in vehicle-treated mice to 35.0±3.7 s and 45.7±4.5 s, respectively.
Orexin A human, rat, mouse (3, 10 and 30 mg/kg; i.v.) was given immediately before phenylp-quinone (PPQ) and increases the latency to the first PPQ-induced constriction from 357.4±35.2 s in vehicle-treated mice to 500.3±31.2 s at 10 mg/kg and 594.5±5.5 s at 30 mg/kg.
| Animal Model: | Female mice (mouse carrageenan-induced thermal hyperalgesia test) |
| Dosage: | 3, 10 and 30 mg/kg |
| Administration: | i.v.; 5 min pre-test |
| Result: | Significantly increased the latency to response at 10 and 30 mg/kg. |
參考質量標準
外觀:白色粉末純度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
內毒素≤50EU/mg
氨基酸組成分析≤±10%
安全信息
| WGK Germany | 3 |
|---|---|
| 海關編碼 | 2937190000 |
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2025/02/08 | HY-106224 | 促食素A Orexin A (human, rat, mouse) | 205640-90-0 | 1mg | 4400元 |
| 2023/03/20 | HY-106224 | 促食素A Orexin A (human, rat, mouse) | 205640-90-0 | 5mg | 18000元 |