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4-Aminoindole

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4-Aminoindole Basic information
Product Name:4-Aminoindole
Synonyms:4-Aminoindole ,97%;4-Aminoindole;4-AMinoindole, 97% 500MG;(Indol-4-yl)amine;5-methoxyl indole-carboxaldehyde;4-AMINOINDOLINE / 4-INDOLAMINE;4-AMinoindole 97%;4-Aiminoindole
CAS:5192-23-4
MF:C8H8N2
MW:132.16
EINECS:621-202-0
Product Categories:Building Blocks;Heterocycle-Indole series;C7 to C9;Chemical Synthesis;Heterocyclic Building Blocks;Pyrroles & Indoles;Indoles and derivatives;Amines;Pyrroles & Indoles;Indole;Indoles
Mol File:5192-23-4.mol
4-Aminoindole Structure
4-Aminoindole Chemical Properties
Melting point 106-109 °C (lit.)
Boiling point 354.0±15.0 °C(Predicted)
density 1.268±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
form powder to crystal
pka18.23±0.30(Predicted)
color White to Gray to Brown
Water Solubility Insoluble
Sensitive Air Sensitive
BRN 114919
InChIInChI=1S/C8H8N2/c9-7-2-1-3-8-6(7)4-5-10-8/h1-5,10H,9H2
InChIKeyLUNUNJFSHKSXGQ-UHFFFAOYSA-N
SMILESN1C2=C(C(N)=CC=C2)C=C1
CAS DataBase Reference5192-23-4(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36-24/25
WGK Germany 3
8-10-34
HazardClass AIR SENSITIVE, IRRITANT-HARMFUL, KEEP COLD
HS Code 29339990
MSDS Information
ProviderLanguage
4-Aminoindole English
SigmaAldrich English
ACROS English
ALFA English
4-Aminoindole Usage And Synthesis
Chemical PropertiesGreenish-grey to tan powder
UsesReactant for preparation of:• ;Inhibitors of bacterial thymidylate synthase1• ;Mimetics of non-alkaloid toxin lignan anticancer and antiviral agent Podophyllotoxin (PPT)2• ;Inhibitors of Gli1-mediated transcription in the Hedgehog pathway3• ;Protein kinase C θ (PKCθ) inhibitors4• ;Indolic non-peptidic HIV protease inhibitors5• ;Transient receptor potential cation channel subfamily V member 1 (TRPV1) antagonists6• ;Cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors7• ;11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibi
Uses4-Aminoindole may be used to synthesize:
  • macrolactam tumour promoter indolactam V
  • tricyclic structure of 2-substituted-pyrrolo[2,3-h]quinolin-4-one
  • 4-azidoindole
DefinitionChEBI: 4-Aminoindole is a member of indoles.
Synthesis Reference(s)The Journal of Organic Chemistry, 48, p. 5130, 1983 DOI: 10.1021/jo00173a071
General Description4-Aminoindole is an indole derivative. Its cytokinin activity has been assessed by tobacco pith callus bioassay. 4-Aminoindole can be prepared by reacting 2,6-dinitrotoluene and N,N-dimethylformamide dimethylacetal in anhydrous DMF.
4-Aminoindole Preparation Products And Raw materials
Preparation ProductsTosyl-1H-indol-4-amine-->(1H-INDOL-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER-->4-(Piperazino)indole
Tag:4-Aminoindole(5192-23-4) Related Product Information
4-Nitroindole (-)-INDOLACTAM V 4-(Piperazino)indole 4-Aminoindole 1H-Indol-2-amine 5-BOC-AMINOINDAZOLE METHYL 6-AMINO-4-INDOLECARBOXYLATE 4-Methyl-5-aminoindole 7-Aminoindole 1-BOC-4-AMINOINDOLE (1H-INDOL-5-YL)-CARBAMIC ACID TERT-BUTYL ESTER 5-AMINO-1-N-METHYLINDOLE 7-Aminooxindole 1-(4-Aminoindoline)ethanone ,98% 7-N-BOC-AMINO-INDOLE DL-Tryptophan 1-Boc-5-aminoindole 6-Aminoindole

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