EthanediaMide iMpurity F manufacturers
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| | EthanediaMide iMpurity F Basic information |
| Product Name: | EthanediaMide iMpurity F | | Synonyms: | N1-(5-chloropyridin-2-yl)-N2-((1S,2R,4S)-2-[(tert-Butoxycarbonyl)Amino ]-4-[(dimethylamino)carbonyl]-cyclohexyl) oxalamide dimethanesulfonate;EthanediaMide iMpurity F;N1-{(1S,2R,4S)-2-Amino-4-[(dimethylamino)carbonyl]cyclohexyl}-N2-(5-chloropyridin-2-yl)ethanediamide;Edoxaban-6;Edoxaban impurity 14/N1-(5-chloropyridin-2-yl)-N2-((1S,2R,4S)-2-[(tert-Butoxy carbonyl)Amino]-4-[(dimethylamino)carbonyl]-cyclohexyl) oxalamide dimethanesulfonate;Edoxaban iMpurities 6;Ethanediamide, N1-[(1S,2R,4S)-2-amino-4-[(dimethylamino)carbonyl]cyclohexyl]-N2-(5-chloro-2-pyridinyl)-;N1-((1S,2R,4S)-2-Amino-4-(dimethylcarbamoyl)cyclohexyl)-N2-(5-chloropyridin-2-yl)oxalamide (Edoxaban Impurity) | | CAS: | 480452-37-7 | | MF: | C16H22ClN5O3 | | MW: | 367.83 | | EINECS: | | | Product Categories: | | | Mol File: | 480452-37-7.mol |  |
| | EthanediaMide iMpurity F Chemical Properties |
| density | 1.34±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | form | Solid | | pka | 9.46±0.70(Predicted) |
| | EthanediaMide iMpurity F Usage And Synthesis |
| Uses | Edoxaban impurity 6 is an impurity of Edoxaban. Edoxaban (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with Kis of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and can be used for stroke prevention[1][2]. | | References | [1] Furugohri T, et al. DU-176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles. J Thromb Haemost. 2008 Sep;6(9):1542-9. DOI:10.1111/j.1538-7836.2008.03064.x
[2] Mendell J, Lee F, Chen S, The Effects of the Antiplatelet Agents, Aspirin and Naproxen, on Pharmacokinetics and Pharmacodynamics of the Anticoagulant Edoxaban, a Direct Factor Xa Inhibitor. J Cardiovasc Pharmacol. 2013 Apr 23. DOI:10.1097/FJC.0b013e3182970991 |
| | EthanediaMide iMpurity F Preparation Products And Raw materials |
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