杯莧甾酮
| 中文名稱 | 杯莧甾酮 |
|---|---|
| 中文同義詞 | 杯覓甾酮;杯莧甾酮(標(biāo)準(zhǔn)品);杯莧甾酮;杯莧甾酮(杯覓甾酮);CYASTERONE 杯莧甾酮;杯莧甾酮, 來源于川牛膝;(3S,4S,5R)-4-((2R,3R)-2,3-二羥基-3-((2S,3R,5R,9R,10R,13R,17S)-2,3,14-三羥基- 10,13-二甲基-6-氧代-2,3,4,5,6,9,10,11,12,13,14,15,16,17-十四氫-1H-環(huán)戊二烯并[A]菲-17-丁基)-5-羥基-3-甲基四氫-2H-吡喃-2-酮;杯莧甾酮(對照品) |
| 英文名稱 | Cyasterone |
| 英文同義詞 | CYASTERONE;(3S,4S,5R)-4-[(2R,3R)-2,3-Dihydroxy-3-[(2S,3R,5R,9R,10R,13R,14S,17S)-2,3,14-trihydroxy-10,13-dimethyl-6-oxo-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-17-yl]butyl]-3,5-dimethyloxolan-2-one;(22R,24S,25S,28R)-2β,3β,14,20,22,28-Hexahydroxy-6-oxo(26-13C)-5β-stigmasta-7-ene-26-oic acid γ-lactone;7,(5BETA)-CHOLESTEN-26-CARBOXYLIC ACID-24BETA-(1-HYDROXYETHYL)-2BETA, 3BETA, 14ALPHA,20BETA, 22R-PENTOL-6-ONE GAMMA-LACTONE;(22r,24s,25s,28r)-gamma-lacton;2-beta,3-beta,14,20,22,28-hexahydroxy-6-oxo-5-beta-stigmast-7-en-26-oicaci;cyasteron;Cyasterone, 98%, from Cyathula officinalis K.C. Kuan |
| CAS號 | 17086-76-9 |
| 分子式 | C29H44O8 |
| 分子量 | 520.65 |
| EINECS號 | |
| 相關(guān)類別 | 對照品;植提標(biāo)準(zhǔn)品;中藥對照品;標(biāo)準(zhǔn)品;植物提取物;可定制;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;分析試劑標(biāo)準(zhǔn)品;標(biāo)準(zhǔn)品-中藥標(biāo)準(zhǔn)品;標(biāo)準(zhǔn)品-對照品;新品;標(biāo)準(zhǔn)品 -中藥標(biāo)準(zhǔn)品;其它萜類;標(biāo)準(zhǔn)品，對照品 |
| Mol文件 | 17086-76-9.mol |
| 結(jié)構(gòu)式 |  |
杯莧甾酮 性質(zhì)
| 熔點(diǎn) | 164～166℃ |
|---|---|
| 沸點(diǎn) | 735.2±60.0 °C(Predicted) |
| 密度 | 1.31±0.1 g/cm3(Predicted) |
| 儲存條件 | under inert gas (nitrogen or Argon) at 2–8 °C |
| 溶解度 | 溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。 |
| 形態(tài) | 粉末 |
| 酸度系數(shù)(pKa) | 14.12±0.70(Predicted) |
| 顏色 | 白色至米白色 |
IC50: EGFR
Cyasterone exerts cytotoxicity on multiple cell lines: HeLa (IC 50 =77.24 μg/ml); HepG-2 (IC 50 =52.03 μg/ml); MCF-7 (IC 50 =82.07 μg/ml) and MCF-7 (IC 50 =82.07 μg/ml). And It has none cytotoxicity (IC 50 >400 μg/ml) on 3 types of carcinoma (HT-29, Caco-2, T47D) and 1 type of normal (NIH 3T3) cell lines. Cyasterone (0-60 μg/ml; 48 hours) causes a significantly decreasing of the cell proliferation. It inhibits cell growth as a dose-dependent manner, exhibits IC 50 values of 38.50 μg/ml and 32.96 μg/ml, respectively. Cyasterone (0-60 μg/ml; 24 hours) decreases p-EGFR, p-MEK, and p-mTOR as a dose-dependent manner in A549 cells, it affects the MAPK signaling pathway activities.
Cell Viability Assay
| Cell Line: | A549 cells and MGC823 cells |
| Concentration: | 0 μg/ml, 20 μg/ml, 40 μg/ml, 60 μg/ml |
| Incubation Time: | 24 hours |
| Result: | Inhibited cell proliferation as a dose-dependent manner. |
Western Blot Analysis
| Cell Line: | A549 cells |
| Concentration: | 0 μg/ml, 20 μg/ml, 40 μg/ml, 60 μg/ml |
| Incubation Time: | 24 hours |
| Result: | Surpressed p-EGFR, p-MEK, and p-mTOR expression. |
Cyasterone (intraperitoneal injection; 5 mg/kg, 10 mg/kg and 15 mg/kg; 21 days) has anti-proliferation effect in vivo and inhibits MGC823 cells xenografted tumor growth in vivo with few changes in body weights.
| Animal Model: | MGC823 xenograft tumor in BALB/C-nu mice |
| Dosage: | 5 mg/kg, 10 mg/kg and 15 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Inhibited MGC823 xenograft tumor growth in vivo. |
藥理藥效:養(yǎng)血舒筋, 祛風(fēng)除濕。
安全信息
| 安全說明 | 24/25 |
|---|---|
| 海關(guān)編碼 | 29322090 |
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2025/02/08 | HY-N0211 | 杯莧甾酮 Cyasterone | 17086-76-9 | 1 mg | 304元 |
| 2025/02/08 | HY-N0211 | 杯莧甾酮 Cyasterone | 17086-76-9 | 5mg | 800元 |