辛伐他汀鈉鹽
| 中文名稱 | 辛伐他汀鈉鹽 |
|---|---|
| 中文同義詞 | 羥基辛伐他汀酸鈉;辛伐他汀羥基酸鈉鹽-D6;辛伐他汀鈉鹽;辛伐他汀羥基酸鈉鹽;辛伐他汀雜質(zhì)A;辛伐他汀雜質(zhì)A(EP) 標(biāo)準(zhǔn)品;辛伐他汀雜質(zhì)01(NA);辛伐他汀EP雜質(zhì)鈉鹽 |
| 英文名稱 | SIMVASTATIN, SODIUM SALT |
| 英文同義詞 | SIMVASTATIN HYDROXY ACID SODIUM SALT;SIMVASTATIN, SODIUM SALT;IMp. A (EP) as SodiuM Salt: (3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-[(2,2-DiMethylbutanoyl)oxy]-2,6-diMethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic Acid SodiuM Salt (Tenivastatin SodiuM Salt;Simvastatin Impurity as Sodium Salt;Simvastati;SiMvastatin IMp. A (EP) as SodiuM Salt;sodium,(3R,5S)-7-[(1R,2R,6S,8S)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate;Simvastatin hydroxyl acid sodium salt-d6 |
| CAS號 | 101314-97-0 |
| 分子式 | C25H41NaO6 |
| 分子量 | 460.59 |
| EINECS號 | |
| 相關(guān)類別 | 168- 辛伐他汀;雜質(zhì)對照品 |
| Mol文件 | Mol File |
| 結(jié)構(gòu)式 |  |
辛伐他汀鈉鹽 性質(zhì)
| 熔點 | >122°C (dec.) |
|---|---|
| 儲存條件 | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| 溶解度 | DMSO（少許）、甲醇（少許）、水（少許） |
| 形態(tài) | 白色粉末狀固體。 |
| 顏色 | 白色至淺棕色 |
| 穩(wěn)定性 | 吸濕性 |
Simvastatin hydroxy acid sodium (Tenivastatin sodium; Simvastatin Impurity A sodium) 是辛伐他汀 (HY-17502) 活性水解代謝物。Simvastatin 是一種競爭性的 HMG-CoA 還原酶抑制劑， Ki 值為 0.2 nM。
Simvastatin sodium shows a inhibition of HMG-CoA reductase in human lymphoblasts and SV40 transformed MRCS fibroblasts.Simvastatin sodium (100 μM) inhibits the Na + /H + antiport activity leading to a fall of intracellular pH and to a reduced cell proliferation.And the inhibitory effect is prevented by mevalonate but not dolichol or squalene.
Simvastatin sodium (oral administration; 8 mg/kg; 18 days) reduces plasma cholesterol levels 33%, simvastatin can be used in combination with ezetimibe to treat dyslipidemia.