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妥布特羅

妥布特羅

中文名稱妥布特羅
中文同義詞妥洛特羅;妥布特羅;alpha-[(叔丁基氨基)甲基]-鄰氯苯甲醇;妥布特羅溶液,100PPM;妥布特羅 標(biāo)準(zhǔn)品;C-78 FREE BASE;甲醇中妥布特羅
英文名稱Tulobuterol
英文同義詞TULOBUTEROL;TulobuterolHcl56776-01-3/Base;Tulobuterol(baseandorunspecifiedsalt);alpha-[(tert-butylamino)methyl]-o-chlorobenzyl alcohol;2-Chloro-a-[[(1,1-dimethylethyl)amino]methyl]benzenemethano;Benzenemethanol, 2-chloro-a-[[(1,1-dimethylethyl)amino]methyl]- (9CI);HN 078;o-Chloro-a-[(tert-butylamino)methyl]benzyl alcohol
CAS號(hào)41570-61-0
分子式C12H18ClNO
分子量227.73
EINECS號(hào)
相關(guān)類別瘦肉精類;醫(yī)藥 平喘藥;醫(yī)藥原料;API;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
Mol文件41570-61-0.mol
結(jié)構(gòu)式妥布特羅 結(jié)構(gòu)式

妥布特羅 性質(zhì)

熔點(diǎn)89-91°C
沸點(diǎn)338.2±27.0 °C(Predicted)
密度1.098±0.06 g/cm3(Predicted)
RTECS號(hào)DA4734170
儲(chǔ)存條件-20°C Freezer
溶解度可溶于DMSO(少許)、甲醇(少許)
酸度系數(shù)(pKa)13.62±0.20(Predicted)
形態(tài)固體
顏色白色至類白色
CAS 數(shù)據(jù)庫41570-61-0(CAS DataBase Reference)

妥布特羅 用途與合成方法

Tulobuterol (C-78 free base) 是一種長(zhǎng)效的 β2 腎上腺素受體 (β2-adrenoceptor) 激動(dòng)劑,可減少慢性阻塞性肺疾病和支氣管哮喘的發(fā)作頻率。Tulobuterol 也是一種擬交感神經(jīng)藥,用作透皮貼劑,可增加正常的橫膈膜肌肉力量。

β2-adrenoceptor

Tulobuterol (0.1 μM; 24 hours or 72 hours; human tracheal epithelial cells) treatment decreases the RV14 RNA levels at 1 day and at 3 days after infection. The concentrations of sICAM-1 in the supernatants of the cells treated with tulobutero are significantly lower than those in the cells treated with vehicle before RV14 infection. Treatment with Tulobuterol reduces the number of acidic endosomes with green fluorescence in the cells and the fluorescence intensity of acidic endosomes in the cells. Also reduces the RV14 infection-induced secretion of IL-1β, IL-6, and IL-8. Tulobuterol treatment produces a small but significant reduction in the amount of p50, p65, and c-Rel of NF-κB induced by RV14 infection.

RT-PCR

Cell Line: Human tracheal epithelial cells infected with RV14
Concentration: 0.1 μM
Incubation Time: 24 hours or 72 hours
Result: Decreased the RV14 RNA levels at 1 day and at 3 days after infection. The concentrations of sICAM-1 in the supernatants of the cells were significantly lower. Reduced the number of acidic endosomes with green fluorescence in the cells and the fluorescence intensity of acidic endosomes in the cells. Also reduced the RV14 infection-induced secretion of IL-1β, IL-6, and IL-8. And produced a small but significant reduction in the amount of p50, p65, and c-Rel of NF-κB induced by RV14 infection.

In vivo effect of Tulobuterol is examined the on the contractility of diaphragm muscles prepared from mice (BALBs/c mice; 21.7 ± 0.2 g) treated with Endotoxin. Contractile parameters of force-frequency curves and twitch kinetics using untreated or treated diaphragm muscles at 0 (E0) and 4 (E4) hours after E. coli endotoxin (20 mg/kg) administration are measured. E0 and E4 diaphragm muscles are analyzed at 0, 12, and 24 h after transdermal Tulobuterol treatment. The force-frequency curves of E0 and E4 diaphragm muscles at three time points are not significantly changed each other, indicating that Tulobuterol patch restores the muscle contractility. Thus, diaphragm muscle contractility is maintained during 4 h of endotoxin administration with Tulobuterol patch for over 24 h.

安全信息

安全說明24/25
海關(guān)編碼29214990
毒性LD50 in male mice, rats, rabbits (mg/kg): 305, 850, 563 orally; 170, 417, 164 s.c. (Kubo, 1975)

MSDS信息

更新日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2025/02/08HY-B1810妥布特羅
Tulobuterol
41570-61-050mg700元
2025/02/08HY-B1810妥布特羅
Tulobuterol
41570-61-010 mM * 1 mLin DMSO770元
"妥布特羅"相關(guān)產(chǎn)品信息
2-氯苯甲酸 氨基乙醛縮二甲醇 2-氯苯酚 鄰氯苯乙酸 丙烯酸甲酯 乙酸甲酯 芐嘧磺隆 鄰氯苯甲醛 醚菌酯 甲醇 尼泊金甲酯 對(duì)氨基苯甲醇 甲基硫菌靈 鄰氯苯基環(huán)戊基酮 溴甲烷 甲基對(duì)硫磷 鹽酸妥布特羅 妥布特羅
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