妥布特羅
中文名稱 | 妥布特羅 |
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中文同義詞 | 妥洛特羅;妥布特羅;alpha-[(叔丁基氨基)甲基]-鄰氯苯甲醇;妥布特羅溶液,100PPM;妥布特羅 標(biāo)準(zhǔn)品;C-78 FREE BASE;甲醇中妥布特羅 |
英文名稱 | Tulobuterol |
英文同義詞 | TULOBUTEROL;TulobuterolHcl56776-01-3/Base;Tulobuterol(baseandorunspecifiedsalt);alpha-[(tert-butylamino)methyl]-o-chlorobenzyl alcohol;2-Chloro-a-[[(1,1-dimethylethyl)amino]methyl]benzenemethano;Benzenemethanol, 2-chloro-a-[[(1,1-dimethylethyl)amino]methyl]- (9CI);HN 078;o-Chloro-a-[(tert-butylamino)methyl]benzyl alcohol |
CAS號(hào) | 41570-61-0 |
分子式 | C12H18ClNO |
分子量 | 227.73 |
EINECS號(hào) | |
相關(guān)類別 | 瘦肉精類;醫(yī)藥 平喘藥;醫(yī)藥原料;API;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals |
Mol文件 | 41570-61-0.mol |
結(jié)構(gòu)式 | ![]() |
妥布特羅 性質(zhì)
熔點(diǎn) | 89-91°C |
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沸點(diǎn) | 338.2±27.0 °C(Predicted) |
密度 | 1.098±0.06 g/cm3(Predicted) |
RTECS號(hào) | DA4734170 |
儲(chǔ)存條件 | -20°C Freezer |
溶解度 | 可溶于DMSO(少許)、甲醇(少許) |
酸度系數(shù)(pKa) | 13.62±0.20(Predicted) |
形態(tài) | 固體 |
顏色 | 白色至類白色 |
CAS 數(shù)據(jù)庫 | 41570-61-0(CAS DataBase Reference) |
β2-adrenoceptor
Tulobuterol (0.1 μM; 24 hours or 72 hours; human tracheal epithelial cells) treatment decreases the RV14 RNA levels at 1 day and at 3 days after infection. The concentrations of sICAM-1 in the supernatants of the cells treated with tulobutero are significantly lower than those in the cells treated with vehicle before RV14 infection. Treatment with Tulobuterol reduces the number of acidic endosomes with green fluorescence in the cells and the fluorescence intensity of acidic endosomes in the cells. Also reduces the RV14 infection-induced secretion of IL-1β, IL-6, and IL-8. Tulobuterol treatment produces a small but significant reduction in the amount of p50, p65, and c-Rel of NF-κB induced by RV14 infection.
RT-PCR
Cell Line: | Human tracheal epithelial cells infected with RV14 |
Concentration: | 0.1 μM |
Incubation Time: | 24 hours or 72 hours |
Result: | Decreased the RV14 RNA levels at 1 day and at 3 days after infection. The concentrations of sICAM-1 in the supernatants of the cells were significantly lower. Reduced the number of acidic endosomes with green fluorescence in the cells and the fluorescence intensity of acidic endosomes in the cells. Also reduced the RV14 infection-induced secretion of IL-1β, IL-6, and IL-8. And produced a small but significant reduction in the amount of p50, p65, and c-Rel of NF-κB induced by RV14 infection. |
In vivo effect of Tulobuterol is examined the on the contractility of diaphragm muscles prepared from mice (BALBs/c mice; 21.7 ± 0.2 g) treated with Endotoxin. Contractile parameters of force-frequency curves and twitch kinetics using untreated or treated diaphragm muscles at 0 (E0) and 4 (E4) hours after E. coli endotoxin (20 mg/kg) administration are measured. E0 and E4 diaphragm muscles are analyzed at 0, 12, and 24 h after transdermal Tulobuterol treatment. The force-frequency curves of E0 and E4 diaphragm muscles at three time points are not significantly changed each other, indicating that Tulobuterol patch restores the muscle contractility. Thus, diaphragm muscle contractility is maintained during 4 h of endotoxin administration with Tulobuterol patch for over 24 h.
安全信息
安全說明 | 24/25 |
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海關(guān)編碼 | 29214990 |
毒性 | LD50 in male mice, rats, rabbits (mg/kg): 305, 850, 563 orally; 170, 417, 164 s.c. (Kubo, 1975) |
更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
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2025/02/08 | HY-B1810 | 妥布特羅 Tulobuterol | 41570-61-0 | 50mg | 700元 |
2025/02/08 | HY-B1810 | 妥布特羅 Tulobuterol | 41570-61-0 | 10 mM * 1 mLin DMSO | 770元 |