ALKYNE-PEG9-BR
| 中文名稱(chēng) | ALKYNE-PEG9-BR |
|---|---|
| 中文同義詞 | 丙炔-九聚乙二醇-溴;炔-九聚乙二醇-溴;丙炔基-PEG9-溴;炔丙基PEG9-溴化物;炔丙基-九聚乙二醇-溴 |
| 英文名稱(chēng) | Propargyl-PEG9-bromide |
| 英文同義詞 | Propargyl-PEG9-bromide;Alkyne-PEG9-Br;Propargyl-PEG9-Br;3,6,9,12,15,18,21,24,27-Nonaoxatriacont-29-yne, 1-bromo-;Propargyl-PEG9-Br/3,6,9,12,15,18,21,24,27-Nonaoxatriacont-29-yne, 1-bromo- |
| CAS號(hào) | 2055042-83-4 |
| 分子式 | C21H39BrO9 |
| 分子量 | 515.43 |
| EINECS號(hào) | |
| 相關(guān)類(lèi)別 | 助劑 |
| Mol文件 | 2055042-83-4.mol |
| 結(jié)構(gòu)式 |  |
ALKYNE-PEG9-BR 性質(zhì)
| 沸點(diǎn) | 525.6±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.200±0.06 g/cm3(Predicted) |
Propargyl-PEG9-bromide 是一種 PROTAC 連接橋，屬于 PEG 類(lèi)。Propargyl-PEG9-bromide 可用于合成一系列 PROTAC 分子。Propargyl-PEG9-bromide 是一種不可降解 (non-cleavable) 的 ADC 連接橋，用于抗體藥物結(jié)合物 (ADCs) 的合成。
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Non-cleavable
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PEGs
|
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.