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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >Pyridine compound >Ethylpyridine >Tak-715

Tak-715

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Company Name: ATK CHEMICAL COMPANY LIMITED
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Products Intro: Product Name:TAK-715
CAS:303162-79-0
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
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Products Intro: Product Name:TAK-715
CAS:303162-79-0
Purity:98% HPLC LCMS Package:10G;20G
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Products Intro: Product Name:tak-715
CAS:303162-79-0
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CAS:303162-79-0
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Products Intro: Product Name:TAK-715
CAS:303162-79-0
Purity:99.69% Package:1mg;34USD|2mg;48USD|5mg;79USD

Tak-715 manufacturers

  • Tak-715
  • Tak-715 pictures
  • $1.10 / 1g
  • 2025-04-17
  • CAS:303162-79-0
  • Min. Order: 1g
  • Purity: 99.0% min
  • Supply Ability: 100 tons min
  • TAK-715
  • TAK-715 pictures
  • $34.00 / 1mg
  • 2024-11-19
  • CAS:303162-79-0
  • Min. Order:
  • Purity: 99.69%
  • Supply Ability: 10g
  • Tak-715
  • Tak-715 pictures
  • $9.80 / 1.79999995231628KG
  • 2020-01-13
  • CAS:303162-79-0
  • Min. Order: 1g
  • Purity: ≥99%
  • Supply Ability: 100kg
Tak-715 Basic information
Product Name:Tak-715
Synonyms:Tak-715;N-(4-(2-Ethyl-4-(3-methylphenyl)-thiazol-5-yl)pyridin-2-yl)benzamide;BenzaMide, N-[4-[2-ethyl-4-(3-Methylphenyl)-5-thiazolyl]-2-pyridinyl]-;N-(4-(2-Ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl)-2-pyridyl)benzamide;N-(4-(2-Ethyl-4-(m-tolyl)thiazol-5-yl)pyridin-2-yl)benzamide;N-[4-[2-Ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide;TAK-715; TAK715;CS-1566
CAS:303162-79-0
MF:C24H21N3OS
MW:399.51
EINECS:
Product Categories:Inhibitors;MAPK
Mol File:303162-79-0.mol
Tak-715 Structure
Tak-715 Chemical Properties
storage temp. Sealed in dry,2-8°C
solubility DMSO: >15mg/mL
form powder
color faint yellow to dark yellow
Safety Information
Hazard Codes Xn
Risk Statements 22-36
Safety Statements 26
WGK Germany 3
HS Code 2934999090
MSDS Information
Tak-715 Usage And Synthesis
UsesTAK 715 is a p38 MAPK inhibitor for p38α and p38β but not for p38γ and p38δ.
DefinitionChEBI: N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide is a member of benzamides.
Biological Activitytak-715 is a selective inhibitor of p38 mapk with ic50 value of 7.1 nm [1].p38 mitogen-activated protein (map) kinases (p38 mapks) are a class of mitogen-activated protein kinases and play an important role in controlling cellular responses to cytokines and stress. four p38 mapks contain members, p38-α (mapk14), p38-β (mapk11), p38-γ (mapk12/erk6), and p38-δ (mapk13/sapk4), have been identified. abnormal expression of p38 mapks are correlated with a variety of chronic inflammatory diseases and their inhibitors are regarded as promising targets in clinical [1] [2].tak-715 is a potent p38 mapk inhibitor and has a different selectivity with the reported p38 mapk inhibitor vx-745. when tested with human monocytic thp-1 cells, administration of tak-715 exhibited inhibition on p38mapkα with ic50 value of 7.1 nm [1]. in hek293t, u2os, and f9 cells, tak-715 was used to inhibit p38 mapk activity and concluded that p38 mapk had no function in wnt/β-catenin signaling pathway [2].in adjuvant-induced rheumatoid arthritis rat model, administration of tak-715 at dose of 10 mg/kg significantly decreased lps-induced stimulated release of tnf-α (87.6%) by inhibiting p38 mapk activity [1].
in vivo

TAK-715 (compound 8h; 3-30 mg/kg; PO) significantly reduces the secondary paw volume[1].
TAK-715 (10 mg/kg; PO) has a Cmax of 0.19 μg/mL and an AUC of 1.16 μg h/mL.

Animal Model:7-week-old male Lewis rats with arthritis[1]
Dosage:3, 10, 30 mg/kg
Administration:PO; single dose
Result:Significantly reduced the secondary paw volume (25% inhibition)
Animal Model:Rat[1]
Dosage:10 mg/kg (Pharmacokinetic Analysis)
Administration:PO
Result:Had a Cmax of 0.19 μg/mL and an AUC of 1.16 μg?h/mL.
IC 50p38α: 7.1 nM (IC50); p38β: 200 nM (IC50); p38δ: >10 μM (IC50); p38γ: >10 μM (IC50); CK1δ; CK1ε
storage+4°C
references[1]. miwatashi, s., et al., novel inhibitor of p38 map kinase as an anti-tnf-alpha drug: discovery of n-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (tak-715) as a potent and orally active anti-rheumatoid arthritis agent. j med chem, 2005. 48(19): p. 5966-79.
[2]. verkaar, f., et al., inhibition of wnt/beta-catenin signaling by p38 map kinase inhibitors is explained by cross-reactivity with casein kinase idelta/varepsilon. chem biol, 2011. 18(4): p. 485-94.
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