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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Angiogenesis >FLT3 inhibitors >G-749

G-749

G-749 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:G-749
CAS:1457983-28-6
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 18871490254
Email: linda@hubeijusheng.com
Products Intro: Product Name:G-749
CAS:1457983-28-6
Purity:0.99 Package:5KG;1KG
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695
Email: factory@coreychem.com
Products Intro: Product Name: Pyrido[4,3-d]pyrimidin-5(6H)-one, 8-bromo-2-[(1-methyl-4-piperidinyl)amino]-4-[(4-phenoxyphenyl)amino]-
CAS:1457983-28-6
Purity:Min98% HPLC Package:1KG;1USD
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:G-749
CAS:1457983-28-6
Purity:99.34% Package:1mg;40USD|5mg;64USD|10mg;108USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Dideu Industries Group Limited
Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Products Intro: Product Name:G-749
CAS:1457983-28-6
Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer

G-749 manufacturers

  • G-749
  • G-749 pictures
  • $40.00 / 1mg
  • 2024-11-19
  • CAS:1457983-28-6
  • Min. Order:
  • Purity: 99.34%
  • Supply Ability: 10g
  • NAPHTHOL AS-MX
  • NAPHTHOL AS-MX pictures
  • $1.00 / 1ASSAYS
  • 2019-12-23
  • CAS:92-75-1
  • Min. Order: 1ASSAYS
  • Purity: Min98% HPLC
  • Supply Ability: 10t
G-749 Basic information
Description In vitro In vivo
Product Name:G-749
Synonyms:G-49;G-749 (Free base);G-749;8-Bromo-2-[(1-methyl-4-piperidinyl)amino]-4-[(4-phenoxyphenyl)amino]pyrido[4,3-d]pyrimidin-5(6H)-one;8-Bromo-2-[(1-methyl-4-piperidinyl)amino]-4-[(4-phenoxyphenyl)amino]pyrido[4,3-d]pyrimidin-5(6H)-one G749;G-749, >=98%;8-bromo-2-((1-methylpiperidin-4-yl)amino)-4-((4-phenoxyphenyl)amino)pyrido[4,3-d]pyrimidin-5(6H)-one; Pyrido[4,3-d]pyrimidin-5(6H)-one, 8-bromo-2-[(1-methyl-4-piperidinyl)amino]-4-[(4-phenoxyphenyl)amino]-
CAS:1457983-28-6
MF:C25H25BrN6O2
MW:521.41
EINECS:
Product Categories:Inhibitors;API
Mol File:1457983-28-6.mol
G-749 Structure
G-749 Chemical Properties
density 1.487±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility ≥26.05 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form solid
pka8.32±0.40(Predicted)
color White to off-white
Safety Information
MSDS Information
G-749 Usage And Synthesis
DescriptionG-749 is a novel and potent FLT3 inhibitor with IC50 of 0.4 nM, 0.6 nM and 1 nM for FLT3 (WT), FLT3 (D835Y), and Mer, respectively, showing lower potency against other tyrosine kinases.
In vitroIn FLT3-WT-bearing RS4-11 cells and FLT3-ITD-harboring MV4-11 and Molm-14 cells, G-749 potently inhibits autophosphorylation of FLT3 with IC50 of ≤8 nM. In leukemia cells, G-749 shows antiproliferative activity by inducing apoptosis. In BaF3 cell lines that stably express FLT3-ITD/N676D, FLT3-ITD/F691L, FLT3-D835Y, or FLT3-D835Y/N676D, G-749 shows strong inhibitory activity with IC50 of <10 nM, and thus overcomes drug resistance. In blasts of AML patients, G-749 also exhibits potent antileukemia activity.
In vivoIn MV4-11 xenograft mice, G-749 (30 mg/kg p.o.) effectively inhibits the FLT3 pathway and significant inhibits tumor growth. In an orthogonal model of bone marrow engraftment using Molm-14 cells, G-749 (20 mg/kg p.o.) also inhibits tumor growth and increases survival.
DescriptionG-749 is an inhibitor of Fms-like tyrosine receptor kinase 3 (FLT3) with IC50 values ranging from 2.1 to 38.1 nM for wild-type and mutant (constitutively active) FLT3s in Ba/F3 cells expressing recombinant receptors. It also inhibits growth of human leukemia cell lines that express FLT3-ITD mutant kinase (IC50s = 3.5 and 7.5 nM for MV4-11 and Molm-14 cells, respectively) but has no effect on cells that lack FLT3 expression or that express wild-type FLT3. G-749 reduces tumor growth and increases survival in a dose-dependent manner in MV4-11 and Molm-14 murine leukemia xenograft models. It reduces growth of bone marrow blasts derived from acute myeloid leukemia patients, showing more potent inhibition of blasts expressing the FLT3-ITD mutant receptor.
UsesG-749 is a potent FLT3 inhibitor. It shows lower potency against other tyrosine kinases.
references1. lee h k, kim h w, lee i y, et al. g-749, a novel flt3 kinase inhibitor, can overcome drug resistance for the treatment of acute myeloid leukemia. blood, 2014, 123(14): 2209-2219.
G-749 Preparation Products And Raw materials
Tag:G-749(1457983-28-6) Related Product Information
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