2,5-二氯-N-(2-甲基-4-硝基苯基)苯磺酰胺
| 中文名稱 | 2,5-二氯-N-(2-甲基-4-硝基苯基)苯磺酰胺 |
|---|---|
| 中文同義詞 | 2,5-二氯-N-(2-甲基-4-硝基苯基)苯磺酰胺;WNT/BETA-CATENIN和PPAR信號通路抑制劑(FH535);FH535, 一種WNT/Β-CATENIN和PPAR信號傳導抑制劑;化合物FH535;Β-連環(huán)蛋白/TCF 抑制劑, FH535 CALBIOCHEM;FH535,WNT /Β-CANTENIN抑制劑和PPARΓ和PPARΔ拮抗劑;FH-535,WNT/BETA-CANTENIN抑制劑;化合物FH535,10 MM DMSO 溶液 |
| 英文名稱 | FH 535 |
| 英文同義詞 | β-Catenin/Tcf Inhibitor, FH535;FH 535(FH-535);FH535;FH 535;FH-535;FH 535;N-(2-Methyl-4-nitrophenyl)-2,5-dichlorobenzenesulfonaMide;2,5-Dichloro-N-(2-Methyl-4-nitrophenyl)benzenesulfonaMide;2,5-Dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide FH535;β-Catenin/Tcf Inhibitor, FH535 - CAS 108409-83-2 - Calbiochem |
| CAS號 | 108409-83-2 |
| 分子式 | C13H10Cl2N2O4S |
| 分子量 | 361.2 |
| EINECS號 | |
| 相關(guān)類別 | 小分子抑制劑;小分子抑制劑，天然產(chǎn)物;細胞生物學試劑;API;Aromatics;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 108409-83-2.mol |
| 結(jié)構(gòu)式 |  |
2,5-二氯-N-(2-甲基-4-硝基苯基)苯磺酰胺 性質(zhì)
| 熔點 | 141-142℃ |
|---|---|
| 沸點 | 526.3±60.0 °C(Predicted) |
| 密度 | 1.566±0.06 g/cm3(Predicted) |
| 儲存條件 | 2-8°C |
| 溶解度 | DMSO：可溶，20mg/mL |
| 形態(tài) | 黃色固體 |
| 酸度系數(shù)(pKa) | 5.83±0.10(Predicted) |
| 顏色 | 棕褐色 |
| 穩(wěn)定性 | 可在-20°下的DMSO中的溶液保存長達2個月。 |
| InChIKey | AXNUEXXEQGQWPA-UHFFFAOYSA-N |
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PPAR
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Wnt
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β-catenin
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FH535 is an inhibitor of Wnt/β-catenin and PPAR. FH535 inhibits PPARγ and PPARδ transactivation in HCT116 cells. FH535 (15 μM) activities depend on functional PPARδ but does not require a cysteine residue in the PPAR ligand-binding domain. FH535 inhibits recruitment of the coactivators GRIP1 and β-catenin to PPARδ and PPARγ. FH535 shows toxic effects on 12 carcinoma cell lines expressing wnt/β-catenin pathway. FH535 (20 μM) suppresses the β-catenin pathway in pancreatic cancer cells, and inhibits pancreatic cancer cell migration. Furthermore, FH535 (20, 40 μM) inhibits pancreatic cancer cell invasion and cell growth. FH535 represses angiogenesis-related genes in pancreatic cancer cells.
FH535 (25 mg/kg, i.p.) exhibits an anti-tumor effect on pancreatic cancer xenografts in mice. FH535 also represses angiogenesis in pancreatic cancer xenografts.
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2025/02/08 | HY-15721 | 2,5-二氯-N-(2-甲基-4-硝基苯基)苯磺酰胺 FH535 | 108409-83-2 | 1 mg | 174元 |
| 2025/02/08 | HY-15721 | 2,5-二氯-N-(2-甲基-4-硝基苯基)苯磺酰胺 FH535 | 108409-83-2 | 5 mg | 348元 |