|
|
| | Hexamethylphosphorous triamide Basic information |
| | Hexamethylphosphorous triamide Chemical Properties |
| Melting point | -44 °C | | Boiling point | 48-50 °C/12 mmHg (lit.) | | density | 0.898 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.463(lit.) | | Fp | 73 °F | | storage temp. | Inert atmosphere,2-8°C | | form | Liquid | | pka | 8.03±0.70(Predicted) | | Specific Gravity | 0.8980 | | color | Clear colorless to slightly yellow | | Water Solubility | REACTS | | Sensitive | Moisture Sensitive | | BRN | 906778 | | Stability: | Stable. Highly flammable - note low flash point. Incompatible with oxidizing agents. | | InChIKey | XVDBWWRIXBMVJV-UHFFFAOYSA-N | | CAS DataBase Reference | 1608-26-0(CAS DataBase Reference) | | NIST Chemistry Reference | Phosphorous triamide, hexamethyl-(1608-26-0) | | EPA Substance Registry System | Phosphorous triamide, hexamethyl- (1608-26-0) |
| | Hexamethylphosphorous triamide Usage And Synthesis |
| Chemical Properties | colourless liquid | | Uses | Hexamethylphosphorous triamide can be combination with CCl4 for the conversion of hydroxyl groups to the corresponding chlorides; hydroxyl group activation; dehydrations. | | Uses | Hexamethylphosphorous triamide can be uesd in suzuki reaction. | | Uses | Hexamethylphosphorous triamide can be widely used in industry, with applications such as being a flame retardant for building materials to a phosphorylating agent in synthetic chemistry. It is a classified carcinogen. | | reaction suitability | reagent type: ligand
reaction type: Reductions
reagent type: ligand
reaction type: Suzuki-Miyaura Coupling
reagent type: ligand
reaction type: Wittig Reaction | | Purification Methods | It may contain more than 1% of phosphoric triamide. The yellow oil is first distilled at atmospheric pressure, then under reduced pressure and stored under N2. It is air sensitive, TOXIC, and should not be inhaled. It is absorbed through the skin. [Mark Org Synth Coll Vol V 602 1973, Beilstein 4 IV 274.] |
| | Hexamethylphosphorous triamide Preparation Products And Raw materials |
| Raw materials | Sodium hydroxide-->Hydrochloric acid-->Diethyl ether-->Tetrahydrofuran-->Hexane-->Lithium Aluminum Hydride-->Phosphorus trichloride-->Dimethylamine-->Cyclohexane-->N,N-Dimethyltrimethylsilylamine | | Preparation Products | (11AR)-(+)-10,11,12,13-TETRAHYDRODIINDENO[7,1-DE:1',7'-FG][1,3,2]DIOXAPHOSPHOCIN-5-DIMETHYLAMINE-->(11AR)-(+)-10,11,12,13-TETRAHYDRODIINDENO[7,1-DE:1',7'-FG][1,3,2]DIOXAPHOSPHOCIN-5-DIMETHYLAMINE-->DIMEFOX-->N,N-DIMETHYLHEXANAMIDE-->DIMETHYLPHOSPHORAMIDOUS DICHLORIDE-->1,1-DIMETHYLUREA |
|