NHBOC-PEG7-OH
| 中文名稱 | NHBOC-PEG7-OH |
|---|---|
| 中文同義詞 | 叔丁氧酰胺-七聚乙二醇;氨基叔丁酯-七聚乙二醇-羥基;叔丁氧羰基七聚乙二醇羥基;22-羥基-5,8,11,14,17,20-六氧雜-2-氮雜二十二酸叔丁酯;T-BUTYL 20-HYDROXY-3,6,9,12,15,18-HEXAOXAICOSYLCARBAMATE;叔丁氧羰基七聚乙二醇;(20-羥基-3,6,9,12,15,18-六氧雜二十烷基)氨基甲酸叔丁酯;氨基叔丁酯-七聚乙二醇 |
| 英文名稱 | BocNH-PEG7-OH |
| 英文同義詞 | BocNH-PEG7-OH;NHBoc-PEG7-OH;5,8,11,14,17,20-Hexaoxa-2-azadocosanoic acid, 22-hydroxy-, 1,1-dimethylethyl ester;t-boc-N-amido-PEG7-alcohol;t-butyl20-hydroxy-3,6,9,12,15,18-hexaoxaicosylcarbamate;tert-Butyl (20-hydroxy-3,6,9,12,15,18-hexaoxaicosyl)carbamate;20-(Boc-amino)-3,6,9,12,15,18-hexaoxa-1-icosanol;BocNH-PEG7-OH/5,8,11,14,17,20-Hexaoxa-2-azadocosanoic acid, 22-hydroxy-, 1,1-dimethylethyl ester |
| CAS號 | 1292268-13-3 |
| 分子式 | C19H39NO9 |
| 分子量 | 425.51 |
| EINECS號 | |
| 相關(guān)類別 | 其它;助劑 |
| Mol文件 | 1292268-13-3.mol |
| 結(jié)構(gòu)式 |  |
NHBOC-PEG7-OH 性質(zhì)
| 沸點 | 521.1±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.090±0.06 g/cm3(Predicted) |
| 溶解度 | 溶于水、DMSO、DCM、DMF |
| 酸度系數(shù)(pKa) | 12.23±0.46(Predicted) |
| 形態(tài) | 液體 |
| 顏色 | 無色至淺黃 |
N-Boc-PEG7-alcohol 是一種 PROTAC 連接橋，屬于 PEG 類和 Alkyl/ether 類。N-Boc-PEG7-alcohol 可用于合成一系列 PROTAC 分子。N-Boc-PEG7-alcohol 是一種可降解 (cleavable) 的 ADC 連接橋，用于抗體藥物結(jié)合物 (ADCs) 的合成。
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Cleavable
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PEGs
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Alkyl/ether
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PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.