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1,2-脫水肌醇

1,2-脫水肌醇

中文名稱1,2-脫水肌醇
中文同義詞脫水肌醇;環(huán)己烯四醇Β環(huán)氧化物(脫水肌醇);1,2-脫水肌醇;環(huán)己烯四醇Β環(huán)氧化物;REL-(1R,2R,3S,4S,5R,6S)-7-氧雜二環(huán)[4.1.0]庚烷-2,3,4,5-四醇;CONDURITOL B EPOXIDE (CONDURITOL EPOXIDE),BETA-GLUCOSIDASE抑制劑;1,2-脫水肌醇,10 MM DMSO 溶液
英文名稱CONDURITOL B EPOXIDE
英文同義詞conduritolepoxide;(+/-) CONDURITOL B EPOXIDE;CONDURITOL B EPOXIDE;DL-1,2-ANHYDRO-MYO-INOSITOL;1,2-Anhydro-myo-inositol;(1R,2R,3S,4S,5R,6S)-7-oxabicyclo[4.1.0]heptane-2,3,4,5-tetrol;myo-Inositol, 1,2-anhydro- (9CI);4h-3,1-benzoxazin-4-one, 5-methyl-2-(3-nitrophenyl)-
CAS號6090-95-5
分子式C6H10O5
分子量162.14
EINECS號
相關(guān)類別抑制劑;小分子;EPOXYDE;All Inhibitors;Glycosidase Inhibitors;Inhibitors;api
Mol文件6090-95-5.mol
結(jié)構(gòu)式1,2-脫水肌醇 結(jié)構(gòu)式

1,2-脫水肌醇 性質(zhì)

熔點157-159
沸點360.5±42.0 °C(Predicted)
密度1.925±0.06 g/cm3 (20 ºC 760 Torr)
儲存條件2-8°C
溶解度可溶于水(高達25mg/ml)或DMSO
形態(tài)白色固體
酸度系數(shù)(pKa)13.08±0.70(Predicted)
顏色白色
生物來源synthetic (organic)
水溶解性water: 20mg/mL, clear, colorless to faintly yellow
穩(wěn)定性濕氣敏感

1,2-脫水肌醇 用途與合成方法

Conduritol B epoxide 是一種不可逆的,共價的 β-glucosidase 抑制劑。

Treating N2a and Conduritol B epoxide-N2a cells with G6 gave GC reductions to 7% and 26% of untreated levels, respectively. G6 treated Conduritol B epoxide-N2a also has significantly decreased GS. Co-treatment of G6 and dantrolene of Conduritol B epoxide-N2a cells lead to a similar degree of GC and GS reduction as G6 alone, indicating a specific effect of G6 on inhibition of substrate accumulation, Conduritol B epoxide-N2a cells have higher calcium levels than in N2a cells without caffeine at baseline. Conduritol B epoxide-N2a cells show a significant increase in cytosolic calcium levels compared to N2a cells. Conduritol B epoxide-N2a cells show a significant reduction in OCR as evidenced by approximately 50% in all the parameters, including rate of ATP production, basal respiration, and maximal respiration, compared to N2a cells, indicating reduced mitochondrial function in this nGD cell model. In dantrolene-treated Conduritol B epoxide-N2a cells, levels of Ryr3 are increased to 76% of WT level.

Conduritol B epoxide treatment of 4L, 9H, 9V and WT mice (100 mg/kg/day, i.p.) from postnatal day 5 to 11 does not induce α-synuclein aggregates. Long-term daily Conduritol B epoxide treatment of 4L mice (100 mg/kg/day of Conduritol B epoxide from postnatal day 15 for 24 or 36 doses) leads to hind limb paralysis and small amounts of α-synuclein accumulation in the olfactory bulb, brainstem, and PVP near D3V (dorsal 3rd ventricle).

安全信息

WGK Germany3
Hazard NoteHarmful
海關(guān)編碼2932990090

MSDS信息

提供商 語言
英文
更新日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2025/02/08HY-1009441,2-脫水肌醇
Conduritol B epoxide
6090-95-51 mg250元
2025/02/08HY-1009441,2-脫水肌醇
Conduritol B epoxide
6090-95-55mg550元

1,2-脫水肌醇 上下游產(chǎn)品信息

"1,2-脫水肌醇"相關(guān)產(chǎn)品信息
885101-89-3(GW9508) 4-苯基丁酸鈉鹽 1-甘露糖野尻霉素鹽酸鹽 格列本脲 磷脂酰肌醇 D-手性肌醇 環(huán)氧己烷 氧化環(huán)己烯
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