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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >PI3K / Akt / mTOR >PI3K inhibitor >HS-173

HS-173

HS-173 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:HS-173
CAS:1276110-06-5
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695
Email: sales@coreychem.com
Products Intro: Product Name:HS-173
CAS:1276110-06-5
Purity:99% Package:1kg;2USD
Company Name: Hubei xin bonus chemical co. LTD
Tel: 86-13657291602
Email: linda@hubeijusheng.com
Products Intro: Product Name:HS-173
CAS:1276110-06-5
Purity:0.99 Package:5KG;1KG
Company Name: BOC Sciences
Tel: +1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:HS-173
CAS:1276110-06-5
Purity:98% Package:100mg Remarks:BOC Sciences also provides custom synthesis services for HS-173.
Company Name: Chongqing Chemdad Co., Ltd
Tel: +86-023-6139-8061 +86-86-13650506873
Email: sales@chemdad.com
Products Intro: Product Name:HS-173
CAS:1276110-06-5
Purity:0.98 Package:1kg,2kg,5kg,10kg,25kg

HS-173 manufacturers

  • HS-173
  • HS-173 pictures
  • $34.00 / 1mg
  • 2024-11-19
  • CAS:1276110-06-5
  • Min. Order:
  • Purity: 99.64%
  • Supply Ability: 10g
  • HS-173
  • HS-173 pictures
  • $2.00 / 1kg
  • 2019-07-06
  • CAS:1276110-06-5
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 100kg
HS-173 Basic information
Product Name:HS-173
Synonyms:ethyl 6-(5-(phenylsulfonamido)pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxylate;6-[5-[(Phenylsulfonyl)amino]-3-pyridinyl]imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester HS-173;HS-173;6-[5-[(Phenylsulfonyl)amino]-3-pyridinyl]imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester;HS 173;HS173;CS-1007;HS-173, 98%, a novel PI3K inhibitor;Imidazo[1,2-a]pyridine-3-carboxylic acid, 6-[5-[(phenylsulfonyl)amino]-3-pyridinyl]-, ethyl ester
CAS:1276110-06-5
MF:C21H18N4O4S
MW:422.46
EINECS:
Product Categories:Inhibitors
Mol File:1276110-06-5.mol
HS-173 Structure
HS-173 Chemical Properties
Melting point >193°C (dec.)
density 1.38±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility Chloroform (Slightly), DMSO (Slightly)
pka6.84±0.40(Predicted)
form Solid
color Grey to Brown
Safety Information
MSDS Information
HS-173 Usage And Synthesis
DescriptionHS-173 is an imidazopyridine analog that acts as a PI3Kα inhibitor with an IC50 value of 0.8 nM. It demonstrates antiproliferative activity in T47D, SK-BR-3, and MCF-7 cells with IC50 values of 0.6, 1.5, and 7.8 μM, respectively. HS-173 is reported to induce apoptosis by arresting the cell cycle at the G2/M phase and by activating caspases. It has also been shown to block VEGF-induced angiogenesis both in vitro and in vivo.
UsesHS-173 is a potent PI3Kα inhibitor with anticancer activity.
in vitrohs-173 inhibited the pi3k signaling pathway, and showed anti-proliferative effects on cancer cells. also, hs-173 induced cell cycle arrest at the g2/m phase and apoptosis. in addition, hs-173 decreased the expression hif-1a and vegf which play an important role in angiogenesis. this effect was confirmed by the suppression of tube formation and migration assay in vitro [1].
in vivohs-173 diminished blood vessel formation in the matrigel plug assay in mice. these results suggest that hs-173 has potent anti-angiogenic activity in vivo [1].
targetPI3Kα
references[1] lee h, jung kh, jeong y, hong s, hong ss. hs-173, a novel phosphatidylinositol 3-kinase (pi3k) inhibitor, has anti-tumor activity through promoting apoptosis and inhibiting angiogenesis. cancer lett. 2013 jan 1;328(1):152-9.
HS-173 Preparation Products And Raw materials
Tag:HS-173(1276110-06-5) Related Product Information
CCT 244747 6-amino-1,3-dimethyl-4-(4-(trifluoromethyl)phenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile 1-[2-CHLORO-6-[[(3-IODOPHENYL)METHYL]AMINO]-9H-PURIN-9-YL]-1-DEOXY-N-METHYL-BETA-D-RIBOFURANURONAMIDE Naquotinib (mesylate) BI-9564 BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]- (R)-N- (4-(chlorodifluoromethoxy)phenyl)- 6-(3- hydroxypyrrolidin-1- yl)-5- (1H-pyrazol- 5-yl)nicotinamide 4-Propylphenol Gefitinib Alpelisib (BYL719) Rapamycin PI-3065 AZD-9291 4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]-

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