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Kynurenic acid sodium salt

Kynurenic acid sodium salt

中文名稱Kynurenic acid sodium salt
中文同義詞化合物 T22892;4-羥基喹啉-2-甲酸鈉;犬尿喹啉酸鈉鹽;4-羥基喹啉-2-羧酸鈉;化合物 KYNURENIC ACID SODIUM
英文名稱Kynurenic acid sodium salt
英文同義詞Kynurenic acid sodium salt;4-Hydroxyquinoline-2-carboxylicacidsodiumsalt;Kynurenic acid (sodium);Sodium 4-hydroxyquinoline-2-carboxylate
CAS號(hào)2439-02-3
分子式C10H6NNaO3
分子量230.19571
EINECS號(hào)
相關(guān)類別Glutamate
Mol文件2439-02-3.mol
結(jié)構(gòu)式Kynurenic acid sodium salt 結(jié)構(gòu)式

Kynurenic acid sodium salt 性質(zhì)

儲(chǔ)存條件Store at RT
溶解度DMSO : 50 mg/mL (235.67 mM; 需要超聲波)H2O : < 0.1 mg/mL (不溶)
形態(tài)粉末
顏色白色

Kynurenic acid sodium salt 用途與合成方法

Kynurenic acid sodium 是一種內(nèi)源性色氨酸代謝物,是針對(duì)靶點(diǎn) NMDA, glutamate, α7 nicotinic acetylcholine receptor 的光譜性拮抗劑。Kynurenic acid sodium 也是 GPR35/CXCR8 的激動(dòng)劑。

Target: GPR35, NMDA, glutamate, glutamate, α7 nicotinic acetylcholine

GPR35 functions as a receptor for the kynurenine pathway intermediate kynurenic acid. Kynurenic acid elicits calcium mobilization and inositol phosphate production in a GPR35-dependent manner in the presence of G qi/o chimeric G proteins. Kynurenic acid stimulates [ 35 S]guanosine 5′-O-(3-thiotriphosphate) binding in GPR35-expressing cells, an effect abolished by pertussis toxin treatment. Kynurenic acid also induces the internalization of GPR35. KYNA’s neuroinhibitory qualities and its neuroprotective and anticonvulsant effects are discovered using concentrations of the compound in the millimolar range. This, as well as the low affinity of KYNA at each of the three ionotropic glutamate receptors responsible for these effects [NMDA, alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and kainate], together with the realization that KYNA concentrations in the mammalian brain are in the sub-micromolar range, suggested that other receptors might serve as targets of endogenous Kynurenic acid. Kynurenic acid, with a shallower inhibition curve and non-competitively, antagonizes α7nAChRs on cultured hippocampal neurons with an IC 50 in the low micromolar range.

Kynurenic acid affects the activity of leukocytes in the peripheral blood of mice, although the lowest one (2.5 mg/L) has the most profound influence in contrast to the highest one (250 mg/L), which produces the weakest effect. The lowest Kynurenic acid dose stimulates the proliferative response of T lymphocytes (p<0.05), after 7 and 28 days of administering the acid to the animals.

安全信息

MSDS信息

更新日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-107512Kynurenic acid sodium salt
Kynurenic acid sodium
2439-02-3100mg500元
2024/11/08HY-107512Kynurenic acid sodium salt
Kynurenic acid sodium
2439-02-310mM * 1mLin DMSO550元

Kynurenic acid sodium salt 上下游產(chǎn)品信息

"Kynurenic acid sodium salt"相關(guān)產(chǎn)品信息
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