Kynurenic acid sodium salt
中文名稱 | Kynurenic acid sodium salt |
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中文同義詞 | 化合物 T22892;4-羥基喹啉-2-甲酸鈉;犬尿喹啉酸鈉鹽;4-羥基喹啉-2-羧酸鈉;化合物 KYNURENIC ACID SODIUM |
英文名稱 | Kynurenic acid sodium salt |
英文同義詞 | Kynurenic acid sodium salt;4-Hydroxyquinoline-2-carboxylicacidsodiumsalt;Kynurenic acid (sodium);Sodium 4-hydroxyquinoline-2-carboxylate |
CAS號(hào) | 2439-02-3 |
分子式 | C10H6NNaO3 |
分子量 | 230.19571 |
EINECS號(hào) | |
相關(guān)類別 | Glutamate |
Mol文件 | 2439-02-3.mol |
結(jié)構(gòu)式 |
Kynurenic acid sodium salt 性質(zhì)
儲(chǔ)存條件 | Store at RT |
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溶解度 | DMSO : 50 mg/mL (235.67 mM; 需要超聲波)H2O : < 0.1 mg/mL (不溶) |
形態(tài) | 粉末 |
顏色 | 白色 |
Target: GPR35, NMDA, glutamate, glutamate, α7 nicotinic acetylcholine
GPR35 functions as a receptor for the kynurenine pathway intermediate kynurenic acid. Kynurenic acid elicits calcium mobilization and inositol phosphate production in a GPR35-dependent manner in the presence of G qi/o chimeric G proteins. Kynurenic acid stimulates [ 35 S]guanosine 5′-O-(3-thiotriphosphate) binding in GPR35-expressing cells, an effect abolished by pertussis toxin treatment. Kynurenic acid also induces the internalization of GPR35. KYNA’s neuroinhibitory qualities and its neuroprotective and anticonvulsant effects are discovered using concentrations of the compound in the millimolar range. This, as well as the low affinity of KYNA at each of the three ionotropic glutamate receptors responsible for these effects [NMDA, alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and kainate], together with the realization that KYNA concentrations in the mammalian brain are in the sub-micromolar range, suggested that other receptors might serve as targets of endogenous Kynurenic acid. Kynurenic acid, with a shallower inhibition curve and non-competitively, antagonizes α7nAChRs on cultured hippocampal neurons with an IC 50 in the low micromolar range.
Kynurenic acid affects the activity of leukocytes in the peripheral blood of mice, although the lowest one (2.5 mg/L) has the most profound influence in contrast to the highest one (250 mg/L), which produces the weakest effect. The lowest Kynurenic acid dose stimulates the proliferative response of T lymphocytes (p<0.05), after 7 and 28 days of administering the acid to the animals.