Kynurenic acid sodium salt
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- CAS號:
- 2439-02-3
- 英文名:
- Kynurenic acid sodium salt
- 英文別名:
- Kynurenic acid (sodium);Kynurenic acid sodium salt;Sodium 4-hydroxyquinoline-2-carboxylate;4-Hydroxyquinoline-2-carboxylicacidsodiumsalt;Kynurenic acid sodium salt (Aqueous Solution);Kynurenic acid sodium salt (mM/ml), Nicotinic antagonist;Kynurenic acid sodium salt, Endogenous ionotropic / nicotinic antagonist
- 中文名:
- Kynurenic acid sodium salt
- 中文別名:
- 犬尿喹啉酸鈉鹽;化合物 T22892;4-羥基喹啉-2-羧酸鈉;4-羥基喹啉-2-甲酸鈉;化合物 KYNURENIC ACID SODIUM;KYNURENIC ACID SODIUM SALT (AQUEOUS SOLUTION);KYNURENIC ACID SODIUM SALT (MM/ML),NICOTINIC拮抗劑;KYNURENIC ACID SODIUM SALT,ENDOGENOUS IONOTROPIC / NICOTINIC拮抗劑
- CBNumber:
- CB52487574
- 分子式:
- C10H6NNaO3
- 分子量:
- 230.19571
- MOL File:
- 2439-02-3.mol
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Kynurenic acid sodium salt化學(xué)性質(zhì)
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儲(chǔ)存條件:
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Store at RT
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溶解度:
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DMSO : 50 mg/mL (235.67 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
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形態(tài):
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Powder
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顏色:
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Pale
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Kynurenic acid sodium salt性質(zhì)、用途與生產(chǎn)工藝
Kynurenic acid sodium 是一種內(nèi)源性色氨酸代謝物，是針對靶點(diǎn) NMDA, glutamate, α7 nicotinic acetylcholine receptor 的光譜性拮抗劑。Kynurenic acid sodium 也是 GPR35/CXCR8 的激動(dòng)劑。
Target: GPR35, NMDA, glutamate, glutamate, α7 nicotinic acetylcholine
GPR35 functions as a receptor for the kynurenine pathway intermediate kynurenic acid. Kynurenic acid elicits calcium mobilization and inositol phosphate production in a GPR35-dependent manner in the presence of G
qi/o
chimeric G proteins. Kynurenic acid stimulates [
35
S]guanosine 5′-O-(3-thiotriphosphate) binding in GPR35-expressing cells, an effect abolished by pertussis toxin treatment. Kynurenic acid also induces the internalization of GPR35. KYNA’s neuroinhibitory qualities and its neuroprotective and anticonvulsant effects are discovered using concentrations of the compound in the millimolar range. This, as well as the low affinity of KYNA at each of the three ionotropic glutamate receptors responsible for these effects [NMDA, alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and kainate], together with the realization that KYNA concentrations in the mammalian brain are in the sub-micromolar range, suggested that other receptors might serve as targets of endogenous Kynurenic acid. Kynurenic acid, with a shallower inhibition curve and non-competitively, antagonizes α7nAChRs on cultured hippocampal neurons with an IC
50
in the low micromolar range.
Kynurenic acid affects the activity of leukocytes in the peripheral blood of mice, although the lowest one (2.5 mg/L) has the most profound influence in contrast to the highest one (250 mg/L), which produces the weakest effect. The lowest Kynurenic acid dose stimulates the proliferative response of T lymphocytes (p<0.05), after 7 and 28 days of administering the acid to the animals.
Kynurenic acid sodium salt
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價(jià)格 |
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| 2025/02/08 | HY-107512 | Kynurenic acid sodium salt
Kynurenic acid sodium | 2439-02-3 | 100mg | 500元 |
| 2025/02/08 | HY-107512 | Kynurenic acid sodium salt
Kynurenic acid sodium | 2439-02-3 | 10mM * 1mLin DMSO | 550元 |
Kynurenic acid sodium salt
生產(chǎn)廠家
2439-02-3, Kynurenic acid sodium salt 相關(guān)搜索:
- Glutamate
- 抑制劑
- 藥靶配體
- C10H6NNaO3
- KYNURENIC ACID SODIUM SALT,ENDOGENOUS IONOTROPIC / NICOTINIC拮抗劑
- KYNURENIC ACID SODIUM SALT (MM/ML),NICOTINIC拮抗劑
- KYNURENIC ACID SODIUM SALT (AQUEOUS SOLUTION)
- 化合物 KYNURENIC ACID SODIUM
- 4-羥基喹啉-2-羧酸鈉
- 犬尿喹啉酸鈉鹽
- 4-羥基喹啉-2-甲酸鈉
- 化合物 T22892
- 2439-02-3
- Kynurenic acid sodium salt (Aqueous Solution)
- Kynurenic acid sodium salt (mM/ml), Nicotinic antagonist
- Kynurenic acid sodium salt, Endogenous ionotropic / nicotinic antagonist
- Sodium 4-hydroxyquinoline-2-carboxylate
- Kynurenic acid (sodium)
- 4-Hydroxyquinoline-2-carboxylicacidsodiumsalt
- Kynurenic acid sodium salt