CKS 17 manufacturers
- CKS 17
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- $7.00 / 1g
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2024-10-22
- CAS:99273-04-8
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 100kg
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| Product Name: | CKS 17 | | Synonyms: | Aids002113;Aids-002113;Leu-Gln-Asn-Arg-arg-Gly-Leu-Asp-Leu-leu-Phe-Leu-Lys-Glu-Gly-gly-Leu linked to bsa;L-Leucine, L-leucyl-L-glutaminyl-L-asparaginyl-L-arginyl-L-arginylglycyl-L-leucyl-L-.alpha.-aspartyl-L-leucyl-L-leucyl-L-phenylalanyl-L-leucyl-L-lysyl-L-.alpha.-glutamylglycylglycyl-;Lqnrrgldllflkeggl-bsa;CKS-17 H-Leu-Gln-Asn-Arg-Arg-Gly-Leu-Asp-Leu-Leu-Phe-Leu-Lys-Glu-Gly-Gly-Leu-OH;L-Leucyl-L-glutaminyl-L-asparaginyl-L-arginyl-L-arginylglycyl-L-leucyl-L-α-aspartyl-L-leucyl-L-leucyl-L-phenylalanyl-L-leucyl-L-lysyl-L-α-glutamylglycylglycyl-L-leucine;L-Leucine, L-leucyl-L-glutaminyl-L-asparaginyl-L-arginyl-L-arginylglycyl-L-leucyl-L-α-aspartyl-L-leucyl-L-leucyl-L-phenylalanyl-L-leucyl-L-lysyl-L-α-glutamylglycylglycyl- | | CAS: | 99273-04-8 | | MF: | C87H148N26O24 | | MW: | 1942.28 | | EINECS: | | | Product Categories: | | | Mol File: | 99273-04-8.mol |  |
| | CKS 17 Chemical Properties |
| density | 1.41±0.1 g/cm3(Predicted) | | form | Solid | | pka | 3.40±0.10(Predicted) |
| | CKS 17 Usage And Synthesis |
| Uses | CKS-17 is a synthetic retroviral envelope peptide. CKS-17 has the highly conserved amino acid sequences occurring within the transmembrane envelope protein of many animal and human retroviruses. CKS-17 acts as an immunomodulatory epitope and exhibits suppressive properties for numerous immune functions[1][2][3]. | | in vivo | CKS-17 (10 μM; i.d.; B6AF1 mice and C57BL/6J mice) inhibits delayed-type hypersensitivity (DTH) reactions to sheep erythrocytes in the feet of mice[2]. | Animal Model: | B6AF1 mice and C57BL/6J mice with DTH models[2] | | Dosage: | 10 μM | | Administration: | Intradermal injection, into the right hind footpad | | Result: | Had a transient depressive effect on DTH reaction. |
| | References | [1] Haraguchi S, et, al. Induction of intracellular cAMP by a synthetic retroviral envelope peptide: a possible mechanism of immunopathogenesis in retroviral infections. Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5568-71. DOI:10.1073/pnas.92.12.5568
[2] Nelson M, et, al. Effects of CKS-17, a synthetic retroviral envelope peptide, on cell-mediated immunity in vivo: immunosuppression, immunogenicity, and relation to immunosuppressive tumor products. Cancer Immunol Immunother. 1989;30(2):113-8. DOI:10.1007/BF01665962
[3] Nelson M, et, al. Inhibition of interleukin-2 production by tumor cell products and by CKS-17, a synthetic retroviral envelope peptide. Cancer Immunol Immunother. 1990;30(6):331-41. DOI:10.1007/BF01786882 |
| | CKS 17 Preparation Products And Raw materials |
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