新霉素 B 硫酸鹽
| 中文名稱 | 新霉素 B 硫酸鹽 |
|---|---|
| 中文同義詞 | 新霉素 B 硫酸鹽;硫酸新霉素B(硫酸弗蘭西汀);新霉素B硫酸鹽[硫酸弗拉菌素];硫酸新霉素B/硫酸弗蘭西丁;硫酸新霉素B EP標(biāo)準(zhǔn)品;硫酸弗蘭西汀;(2S,3S,4R,5R,6R)-5-氨基-2-(氨基甲基)-6-(((2R,3S,4R,5S)-5-(((1R,2R,3S,5R,6S)-3,5-二氨基-2-(((2R,3R,4R,5S,6R)-3-氨基-6-(氨基甲基)-4,5-二羥基四氫-2H-吡喃-2-基)氧基)-6-羥基環(huán)己基)氧基)-4-羥基-2-(羥甲基)四氫呋喃-3-基)氧基)四氫-2H-吡喃-3,4-二醇三(硫酸鹽);硫酸弗拉霉素 |
| 英文名稱 | Framycetin sulphate |
| 英文同義詞 | NeomycinBsulfate;D-Streptamine, O-2,6-diamino-2,6-dideoxy-.beta.-L-idopyranosyl-(1?3)-O-.beta.-D-ribofuranosyl-(1?5)-O-2,6-diamino-2,6-dideoxy-.alpha.-D-glucopyranosyl-(1?4)-2-deoxy-, sulfate (1:3) (salt);NEOMYCIN SULPHATE B(FRAMYCETIN SULPHATE);Neomycin sulphate B;(2R,3S,4R,5R,6R)-5-Amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2R,3R,4S,5R)-4-[(2S,3S,4S,5R,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxy-oxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxy-cyclohexyl]oxy-oxane-3,4-diol sulphate;Framycetin sulphate;4-O-(2,6-Diamino-2,6-dideoxy-α-D-glucopyranosyl)-5-O-[3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)-β-D-ribofuranosyl]-2-deoxy-D-streptamine/sulfuric acid,(1:3);Einecs 223-969-3 |
| CAS號 | 4146-30-9 |
| 分子式 | C23H48N6O17S |
| 分子量 | 712.72 |
| EINECS號 | 223-969-3 |
| 相關(guān)類別 | 小分子抑制劑;小分子抑制劑，天然產(chǎn)物;原料藥;醫(yī)藥原料;醫(yī)藥原料藥-科研原料;醫(yī)用原料;Inhibitors;科研試劑;農(nóng)用獸用原料;原料;醫(yī)藥化工類;醫(yī)藥原料;獸藥原料;化學(xué)試劑 |
| Mol文件 | 4146-30-9.mol |
| 結(jié)構(gòu)式 |  |
新霉素 B 硫酸鹽 性質(zhì)
| 熔點(diǎn) | >160°C (dec.) |
|---|---|
| 儲存條件 | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| 溶解度 | 易溶于水，極微溶于醇，幾乎不溶于丙酮。 |
| 形態(tài) | 固體 |
| 顏色 | 白色至類白色 |
| 水溶解性 | Water : 250 mg/mL (275.06 mM; Need ultrasonic) |
| 穩(wěn)定性 | 吸濕性 |
| CAS 數(shù)據(jù)庫 | 4146-30-9(CAS DataBase Reference) |
新霉素 B 硫酸鹽的抗菌譜及廣，對革蘭氏陰性菌和革蘭氏陽性菌有極好的殺滅作用，廣泛應(yīng)用于醫(yī)藥和獸藥領(lǐng)域。
Framycetin sulfate (Neomycin B sulfate) 是一種氨基糖苷類抗生素，是一種有效的 RNase P 裂解活性抑制劑，Ki 為 35 μM。Framycetin sulfate 競爭 RNase P RNA 中特定的二價金屬離子結(jié)合位點(diǎn)。Framycetin sulfate 抑制錘頭狀核酶 (hammerhead ribozyme)，Ki 值為 13.5 μM。Framycetin sulfate 是 5″-azido neomycin B 前體，與 miR-525 中的 Drosha 位點(diǎn)結(jié)合，可用于肝性腦病和腸致病性大腸桿菌感染。Ki: 35 μM (RNase P cleavage activity) and 13.5 μM (hammerhead ribozyme)
The inhibition of RNase P RNA cleavage by Framycetin sulfate (Neomycin Bsulfate; Fradiomycin Bsulfate) is sensitive to pH and an increase in pH suppresses the inhibition in other systems.
Framycetin sulfate targets the bacterial and human ribosome and affect translation. 5″-azido neomycin B and Framycetin sulfate selectively inhibit production of the mature miRNA, boosts a downstream protein, and inhibits invasion in HCC cell line.
Framycetin sulfate binds to a structural rather than a sequence motif of the RNA. Its primary cognate target is the decoding site of the 16S rRNA, but it also binds to the Rev-responsive element in HIV-1, group I introns, and the hammerhead ribozyme, and thus inhibits their biological function.
Framycetin sulfate induces misreading of the genetic code during translation and inhibits several ribozymes. The ribosomal target site is the 16 S rRNA 1400 to 1500 region.