MX69
| 中文名稱 | MX69 |
|---|---|
| 中文同義詞 | MDM2/XIAP抑制劑(MX69);4-(8-((3,4-二甲基苯基)氨基磺?；?-3A,4,5,9B-四氫-3H-環(huán)戊二烯并[C]喹啉-4-基)苯甲酸;化合物MX69;化合物MX69,10 MM DMSO 溶液 |
| 英文名稱 | MX-69 |
| 英文同義詞 | MX-69;CS-2402;MX69 (MX 69;Benzoic acid, 4-[8-[[(3,4-dimethylphenyl)amino]sulfonyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]-;E1/E2/E3 Enzyme,inhibit,E3 ligating enzyme,MX 69,Ubiquitin ligase,IAP,MX69,E1 activating enzyme,E2 conjugating enzyme,Ubiquitin conjugating enzyme,MX-69,Inhibitor,Ubiquitin activating enzyme,MDM-2/p53;4-(8-(N-(3,4-Dimethylphenyl)sulfamoyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl)benzoic acid;MX69, 10 mM in DMSO |
| CAS號 | 1005264-47-0 |
| 分子式 | C27H26N2O4S |
| 分子量 | 474.57 |
| EINECS號 | |
| 相關類別 | 抑制劑;細胞生物學試劑 |
| Mol文件 | 1005264-47-0.mol |
| 結(jié)構式 |  |
MX69 性質(zhì)
| 儲存條件 | Store at -20°C |
|---|---|
| 溶解度 | 可溶于DMSO |
| 形態(tài) | 固體 |
| 顏色 | 白色至米白色 |
MX69 是一種 MDM2/XIAP 抑制劑，常用于抗癌研究。
MX69 blocks the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation. MX69 shows minimal inhibitory effect on normal human hematopoiesis in vitro and is very well tolerated in animal models. MX69-induced MDM2 downregulation results not only in inhibition of XIAP expression, but also in activation of p53, which contributes to cancer cell apoptosis in vitro.
MX69-induced MDM2 downregulation results in activation of p53 which contributes to inhibition of cancer cell proliferation in vivo.
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2025/02/08 | HY-100892 | MX69 MX69 | 1005264-47-0 | 5mg | 700元 |
| 2025/02/08 | HY-100892 | MX69 MX69 | 1005264-47-0 | 10mM * 1mLin DMSO | 730元 |