1,2,3,4-四氫-1-(1-萘基甲基)-6,7-異喹啉二醇?xì)滗逅猁}
生物活性體外研究體內(nèi)研究 用途與合成方法 MSDS 1,2,3,4-四氫-1-(1-萘基甲基)-6,7-異喹啉二醇?xì)滗逅猁}價(jià)格(試劑級(jí)) 上下游產(chǎn)品信息
| 中文名稱(chēng) | 1,2,3,4-四氫-1-(1-萘基甲基)-6,7-異喹啉二醇?xì)滗逅猁} |
|---|---|
| 中文同義詞 | 1,2,3,4-四氫-1-(1-萘基甲基)-6,7-異喹啉二醇?xì)滗逅猁};化合物YS-49;1-(萘-1-基甲基)-1,2,3,4-四氫異喹啉-6,7-二醇?xì)滗逅猁};化合物YS-49,10 MM DMSO 溶液 |
| 英文名稱(chēng) | YS 49 |
| 英文同義詞 | YS 49;1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-Isoquinolinediol hydrobromide monohydrate;1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-isoquinolinediol hydrobromide;CS-884;YS 49;YS49;inhibit,YS-49,PI3K,Adrenergic Receptor,Phosphoinositide 3-kinase,PKB,Beta Receptor,YS 49,Akt,Protein kinase B,Inhibitor,YS49,Angiotensin Receptor;YS-49, 10 mM in DMSO |
| CAS號(hào) | 132836-42-1 |
| 分子式 | C20H20BrNO2 |
| 分子量 | 386.2823 |
| EINECS號(hào) | |
| 相關(guān)類(lèi)別 | Akt;mTOR;PI3K;PI3K/Akt/mTOR |
| Mol文件 | 132836-42-1.mol |
| 結(jié)構(gòu)式 |  |
1,2,3,4-四氫-1-(1-萘基甲基)-6,7-異喹啉二醇?xì)滗逅猁} 性質(zhì)
| 儲(chǔ)存條件 | 2-8°C |
|---|---|
| 溶解度 | H2O：>10mg/mL |
| 形態(tài) | 固體 |
| 顏色 | 白色至米白色 |
| 水溶解性 | H2O: >10mg/mL |
YS-49 是 PI3K/Akt (RhoA 的下游靶標(biāo)) 的激活劑，可減少 3-甲基膽堿處理的細(xì)胞中 RhoA/PTEN 的激活。YS-49 能通過(guò)誘導(dǎo)血紅素加氧酶 (HO-1) 來(lái)抑制血管緊張素 II (Ang II) 刺激 VSMC 細(xì)胞的增殖。YS-49 是異喹啉化合物生物堿，因能激活心臟 β-adrenoceptors 而具有強(qiáng)烈的正性肌力作用。
YS-49 (1-100?μM; 18 hours; RAVSMC and RAW 264.7 cells) concentration-dependently inhibits the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to lipopolysaccharide (LPS) plus INF-γ, with
IC
50
values of 22 μM and 30?μM, respectively.
YS-49 (10-100?μM; 18 hours; RAVSMC and RAW 264.7 cells) suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells at the transcriptional level.
Cell Viability Assay
| Cell Line: | RAVSMC and RAW 264.7 cells |
| Concentration: | 10 μΜ, 30 μΜ and 100?μΜ (RAVSMC cells); 1 μΜ, 10 μΜ and 100?μM (RAW 264.7 cells) |
| Incubation Time: | 18 hours |
| Result: | Inhibited the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to LPS+INF-γ, with IC 50 values of 22 and 30?μM, respectively. |
Western Blot Analysis
| Cell Line: | RAVSMC and RAW 264.7 cells |
| Concentration: | 10 μΜ, 30 μΜ and 100?μΜ |
| Incubation Time: | 18 hours |
| Result: | Concentration-dependently inhibited the expression of iNOS protein induced by LPS plus IFN-γ. |
YS-49 (5?mg/kg; intraperitoneal injection; 8 hours; male Sprague Dawley rats) treatment significantly reduces serum NOx levels in LPS-treated rats, the NOx levels reduce from 86 μM to 34 μM.
| Animal Model: | Male Sprague Dawley rats (250-300?g) |
| Dosage: | 5?mg/kg |
| Administration: | Intraperitoneal injection; 8 hours |
| Result: | Serum NOx levels were significantly reduced. |
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2025/02/08 | HY-15477 | 1,2,3,4-四氫-1-(1-萘基甲基)-6,7-異喹啉二醇?xì)滗逅猁} YS-49 | 132836-42-1 | 1 mg | 348元 |
| 2025/02/08 | HY-15477 | 1,2,3,4-四氫-1-(1-萘基甲基)-6,7-異喹啉二醇?xì)滗逅猁} YS-49 | 132836-42-1 | 5 mg | 767元 |