P物質(zhì)
| 中文名稱 | P物質(zhì) |
|---|---|
| 中文同義詞 | P物質(zhì);P物質(zhì)?, >98%;物質(zhì) P;多肽物質(zhì)P;神經(jīng)肽H-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2;ANTI-SUBSTANCE P ANTIBODY-P物質(zhì)抗體;三乙酸多肽物質(zhì)P;P物質(zhì) 酰胺、NEUROKININ P AMIDE |
| 英文名稱 | SUBSTANCE P |
| 英文同義詞 | ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2;H2N-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET;H-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2;SUBSTANCE P, F & D VERSION OF S6883*ACET ATE;(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,5-dioxopentan-2-yl]pentanediamide;SUBSTANCE P (HUMAN, BOVINE, RAT, MOUSE);SUBSTANCE P BOVINE;SUBSTANCE P, [D-ARG1, D-PRO2, D-TRP7,9, LEU11] |
| CAS號 | 33507-63-0 |
| 分子式 | C63H98N18O13S |
| 分子量 | 1347.63 |
| EINECS號 | 251-545-8 |
| 相關(guān)類別 | 人檢測系列;氨基酸及其衍生物;生化試劑;生物化學(xué)品;標(biāo)準(zhǔn)品;Peptide;Tachykinin receptor;TPI;Peptide Receptors |
| Mol文件 | 33507-63-0.mol |
| 結(jié)構(gòu)式 |  |
P物質(zhì) 性質(zhì)
| 熔點(diǎn) | 148 °C |
|---|---|
| 密度 | 1.42±0.1 g/cm3(Predicted) |
| 儲存條件 | −20°C |
| 溶解度 | H2O：1 mg/mL |
| 酸度系數(shù)(pKa) | 13.26±0.46(Predicted) |
| 形態(tài) | 粉末 |
| 顏色 | 白色 |
| 水溶解性 | Soluble in water, DMSO, and Acetic Acid. |
| 序列 | H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 |
| InChIKey | ADNPLDHMAVUMIW-UHFFFAOYSA-N |
Substance P (Neurokinin P) 是一種神經(jīng)肽，在中樞神經(jīng)系統(tǒng)中作為神經(jīng)遞質(zhì)和神經(jīng)調(diào)節(jié)劑。Substance P 的內(nèi)源性受體是神經(jīng)激肽1受體 (neurokinin 1 receptor，NK1R)。
外觀:白色粉末|
Human Endogenous Metabolite
|
The neuropeptide substance P (SP) that are mediated by the neurokinin 1 receptor (NK1-R) desensitize and resensitize, which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R are internalized into the same clathrin immunoreactive vesicles, and then sorted into different compartments. SP is intact at the cell surface and in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells.
化學(xué)性質(zhì)
白色冷凍干燥粉末，易溶于水，高純度的水溶液極易失活，加入吐溫80、明膠、人血漿白蛋白或牛丙種球蛋白可增加其穩(wěn)定性；pH大于8時不穩(wěn)定，遇胃蛋白酶和胰凝乳蛋白酶失活；宜保存于低pH值中，并充氮?dú)饣蚣尤肟寡趸瘎┮员苊馄涫Щ睢?div id="ykaok2ay" class="gsbt">參考質(zhì)量標(biāo)準(zhǔn)純度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
內(nèi)毒素≤50EU/mg
氨基酸組成分析≤±10%
用途
用于生化研究，醫(yī)藥上用作血管擴(kuò)張劑、神經(jīng)調(diào)諧劑，能促進(jìn)唾液分泌，增加毛細(xì)管滲透性，能引起平滑肌的收縮、血壓降低和刺激分泌組織，起痛覺的傳遞作用。生產(chǎn)方法
以牛下丘腦為原料，在丙酮和鹽酸溶液中勻漿，過濾后用石油醚提取，經(jīng)柱層析、紙電泳精制而得。安全信息
| WGK Germany | 3 |
|---|---|
| F | 3-10-21 |
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2025/02/08 | XW3350763003 | P物質(zhì) | 33507-63-0 | 25MG | 2528元 |
| 2025/02/08 | XW3350763002 | P物質(zhì) | 33507-63-0 | 10MG | 1635元 |
上游原料