2-(2,6-Dioxo-3-piperidinyl)-4-[2-[2-(2-propyn-1-yloxy)oxy]ethoxy]-1H-isoindole-1,3(2H)dione

2-(2,6-Dioxo-3-piperidinyl)-4-[2-[2-(2-propyn-1-yloxy)oxy]ethoxy]-1H-isoindole-1,3(2H)dione Suppliers list

Company Name:	TargetMol Chemicals Inc.
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Products Intro:	Product Name:Thalidomide-O-PEG2-propargyl；E3 ligase Ligand-Linker Conjugates 32 CAS:2098487-52-4 Purity:98.00% Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY

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Company Name:	Jilin Chinese Academy of Sciences-yanshen Technology
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Products Intro:	Product Name:2-(2,6-dioxopiperidin-3-yl)-4-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)isoindoline-1,3-dione CAS:2098487-52-4 Purity:95%+ Package:1g;5g;10g;25g;50g;100g; Remarks:accept Custom Synthesis Services, support large packing

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Products Intro:	Product Name:Thalidomide-O-PEG2-Propargyl CAS:2098487-52-4 Purity:>98.00% Package:1g

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Products Intro:	Product Name:Thalidomide-O-PEG2-propargyl CAS:2098487-52-4 Purity:97% Package:$35.9/5mg;$147.9/25mg;$345.9/100mg;Bulk package Remarks:97%

2-(2,6-Dioxo-3-piperidinyl)-4-[2-[2-(2-propyn-1-yloxy)oxy]ethoxy]-1H-isoindole-1,3(2H)dione manufacturers

2-(2,6-Dioxo-3-piperidinyl)-4-[2-[2-(2-propyn-1-yloxy)oxy]ethoxy]-1H-isoindole-1,3(2H)dione Basic information

Product Name:	2-(2,6-Dioxo-3-piperidinyl)-4-[2-[2-(2-propyn-1-yloxy)oxy]ethoxy]-1H-isoindole-1,3(2H)dione
Synonyms:	Thalidomide-linker 5;2-(2,6-Dioxo-3-piperidinyl)-4-[2-[2-(2-propyn-1-yloxy)oxy]ethoxy]-1H-isoindole-1,3(2H)dione;E3 ligase Ligand-Linker Conjugates 32;2-(2,6-dioxopiperidin-3-yl)-4-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)isoindoline-1,3-dione;1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-;Thalidomide 4'-ether-PEG2-alkyne
CAS:	2098487-52-4
MF:	C20H20N2O7
MW:	400.38
EINECS:
Product Categories:	peg
Mol File:	2098487-52-4.mol

2-(2,6-Dioxo-3-piperidinyl)-4-[2-[2-(2-propyn-1-yloxy)oxy]ethoxy]-1H-isoindole-1,3(2H)dione Chemical Properties

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2-(2,6-Dioxo-3-piperidinyl)-4-[2-[2-(2-propyn-1-yloxy)oxy]ethoxy]-1H-isoindole-1,3(2H)dione Usage And Synthesis

Uses	Thalidomide-O-PEG2-propargyl (E3 ligase Ligand-Linker Conjugates 32) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1]. Thalidomide-O-PEG2-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Biological Activity	Thalidomide 4'-ether-PEG2-alkyne is a functionalized cereblon ligand for PROTAC? research and development; incorporates an E3 ligase ligand plus a PEG2 linker with alkyne terminal ready for conjugation to a target protein ligand.
IC 50	Cereblon
storage	Store at -20°C
References	[1] Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61(2):453-461. DOI:10.1021/acs.jmedchem.6b01781

2-(2,6-Dioxo-3-piperidinyl)-4-[2-[2-(2-propyn-1-yloxy)oxy]ethoxy]-1H-isoindole-1,3(2H)dione Preparation Products And Raw materials

Tag:2-(2,6-Dioxo-3-piperidinyl)-4-[2-[2-(2-propyn-1-yloxy)oxy]ethoxy]-1H-isoindole-1,3(2H)dione(2098487-52-4) Related Product Information

Thalidomide-NH-C4-NH-Boc 2-(2,6-DIOXOPIPERIDIN-3-YL)-5-FLUORO-6-(PIPERAZIN-1-YL)ISOINDOLINE-1,3-DIONE HCL 4-(3-azidopropoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Thalidomide-O-PEG4-amine Thalidomide-O-PEG4-NHS ester Thalidomide-O-PEG4-Boc Thalidomide-O-PEG4-azide

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