4-硝基苯基4-(3-苯氧基芐基)哌嗪-1-甲酸叔丁酯
| 中文名稱(chēng) | 4-硝基苯基4-(3-苯氧基芐基)哌嗪-1-甲酸叔丁酯 |
|---|---|
| 中文同義詞 | 4-硝基苯基4-(3-苯氧基芐基)哌嗪-1-甲酸叔丁酯;化合物JZL195;JZL 195 HYDROCHLORIDE,FAAH/MAGL抑制劑 |
| 英文名稱(chēng) | JZL 195 |
| 英文同義詞 | JZL 195;4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate;4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 4-nitrophenyl ester;CS-1586;JZL-195;JZL 195;JZL195;1-Piperazinecarboxylic acid, 4-[(3-phenoxyphenyl)methyl]-, 4-nitrophenyl ester;4-Nitrophenyl 4-[(3-phenoxyphenyl)methyl]-1-piperazinecarboxylate;Autophagy,Monoacylglycerol lipase,inhibit,MAGL,Fatty acid amide hydrolase,JZL-195,JZL195,Inhibitor,FAAH,JZL 195 |
| CAS號(hào) | 1210004-12-8 |
| 分子式 | C24H23N3O5 |
| 分子量 | 433.46 |
| EINECS號(hào) | |
| 相關(guān)類(lèi)別 | 小分子抑制劑;小分子抑制劑，天然產(chǎn)物;醫(yī)藥;Inhibitors;API |
| Mol文件 | 1210004-12-8.mol |
| 結(jié)構(gòu)式 |  |
4-硝基苯基4-(3-苯氧基芐基)哌嗪-1-甲酸叔丁酯 性質(zhì)
| 沸點(diǎn) | 581.8±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.303±0.06 g/cm3(Predicted) |
| 儲(chǔ)存條件 | Sealed in dry,Store in freezer, under -20°C |
| 溶解度 | 加熱時(shí)在DMSO中的溶解度≥5mg/mL |
| 酸度系數(shù)(pKa) | 6.13±0.10(Predicted) |
| 形態(tài) | 粉末 |
| 顏色 | 白色至米色 |
JZL195是有效的FAAH和MAGL抑制劑，IC50分別為2 nM和4 nM。
| Target | Value |
|
FAAH
() | 2 nM |
|
MAGL
() | 4 nM |
JZL195 produces near-complete blockade of FP-Rh labeling of both mouse brain FAAH and MAGL at concentrations as low as 100 nM (IC
50
values of 13 and 19 nM, respectively).
JZL195 inhibits rat and human FAAH and MAGL enzymes with IC
50
values in the range of ≈10-100 nM based on competitive ABPP assays.
JZL195 (20 mg/kg; i.p.) produces an antinociceptive response in the tail immersion assay.
| Animal Model: | Male C57BL/6J mice |
| Dosage: | 20 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Produced a much greater antinociceptive response in the tail immersion assay compared with inhibitors of either FAAH or MAGL alone. |
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-15250 | 4-硝基苯基4-(3-苯氧基芐基)哌嗪-1-甲酸叔丁酯 JZL195 | 1210004-12-8 | 5mg | 500元 |
| 2024/11/08 | HY-15250 | JZL195 | 10 mM * 1 mLin DMSO | 550元 |