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| | 3,4-DIMETHOXYBENZYL BROMIDE Basic information |
| | 3,4-DIMETHOXYBENZYL BROMIDE Chemical Properties |
| Melting point | 56-58℃ | | Boiling point | 273℃ | | density | 1.384 | | Fp | 116℃ | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | solubility | CDCl3; | | form | Solid | | color | Off-white |
| | 3,4-DIMETHOXYBENZYL BROMIDE Usage And Synthesis |
| Uses | Reagent used in the dimethoxybenzyl alkylations. | | Uses | 3,4-DIMETHOXYBENZYL BROMIDE used in the dimethoxybenzyl alkylations. | | Preparation | 3,4-Dimethoxybenzyl Bromide is synthesized from commercially available 3,4-dimethoxybenzyl alcohol and PBr3 or
HBr.[2-3] | | General Description | 3,4-Dimethoxybenzyl Bromide (DMBBr) is used as a reagent for introduction of 3,4-dimethoxybenzyl protecting group, which can be cleaved selectively under
conditions of benzylic oxidation.[1] | | storage | 3,4-Dimethoxybenzyl Bromide reactions are usually carried out in polar solvents such as THF or DMF. The reagent is quite unstable and is best prepared fresh or stored at low
temperature under nitrogen. It is a lachrymator. | | References | 1. (a) Horita, K.; Yoshioka, T.; Tanaka, T.; Oikawa, Y.; Yonemitsu, O. T 1986, 42, 3021. (b) Oikawa, Y.; Tanaka, T.;
Horita, K.; Yoshioka, T.; Yonemitsu, O. TL 1984, 25, 5393.
2. Lakhlifi, T.; Sedqui, A.; Laude, B.; Dinh An, N.; Vebrel, J. CJC 1991, 69, 1156.
3. Coote, S. J.; Davies, S. G.; Middlemiss, D.; Naylor, A. JCS(P1) 1989, 2223. |
| | 3,4-DIMETHOXYBENZYL BROMIDE Preparation Products And Raw materials |
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