西咪替丁亞砜鹽酸鹽
| 中文名稱 | 西咪替丁亞砜鹽酸鹽 |
|---|---|
| 中文同義詞 | 西咪替丁亞砜鹽酸鹽;)-西咪替丁 S-氧化物;(±)-西咪替丁 S-氧化物;西咪替丁EP雜質(zhì)E;西咪替丁亞砜;西咪替丁雜質(zhì)E(EP);西咪替丁雜質(zhì)E(EP) 標(biāo)準(zhǔn)品;西咪替丁雜質(zhì)E |
| 英文名稱 | CIMETIDINE SULPHOXIDE DIHYDROCHLORIDE |
| 英文同義詞 | CIMETIDINE SULPHOXIDE DIHYDROCHLORIDE;cimetidine sulfoxide;1-[2-[(5-Methyl-1H-imidazole-4-yl)methylsulfinyl]ethyl]-3-methyl-2-cyanoguanidine;1-Cyano-3-methyl-2-[2-[[(5-methyl-1H-imidazole-4-yl)methyl]sulfinyl]ethyl]guanidine;2-Cyano-1-methyl-3-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]sulfinyl]ethyl]guanidine;Cimetidine S-oxide;SKF-92452;1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfinyl]ethyl]guanidine |
| CAS號 | 54237-72-8 |
| 分子式 | C10H16N6OS |
| 分子量 | 268.34 |
| EINECS號 | |
| 相關(guān)類別 | 醫(yī)藥原料;雜質(zhì)對照品;Heterocycles, Metabolites & Impurities, Sulfur & Selenium Compounds |
| Mol文件 | 54237-72-8.mol |
| 結(jié)構(gòu)式 |  |
西咪替丁亞砜鹽酸鹽 性質(zhì)
| 熔點 | >180°C (dec.) |
|---|---|
| 沸點 | 594.8±60.0 °C(Predicted) |
| 密度 | 1.39±0.1 g/cm3(Predicted) |
| 儲存條件 | -20°C Freezer |
| 溶解度 | DMSO（微溶，加熱）、甲醇（微溶） |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 13.38±0.10(Predicted) |
| 顏色 | 白色至類白色 |
Cimetidine sulfoxide (Cimetidine sulphoxide) 是一種 Cimetidine 的亞砜代謝產(chǎn)物。Cimetidine 是一種組胺 H2 受體 (H2-receptor) 拮抗劑，可用于消化性潰瘍和上消化道出血的研究。
Histamine H 2 -receptor
Active transport of Cimetidine across the rat small intestine is observable at lower substrate concentrations (40 and 200 μM), but is masked by passive transfer at higher concentrations (400 μM). Cimetidine sulfoxide is detected after some incubations.
The enantiomeric composition of Cimetidine sulfoxide is also determined in rat urine (24 h) following the administration of Cimetidine (30 mg/kg; po) to male Wistar rats. The enantiomeric ratio in this case is found to be (+/?) 57:43.
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2025/02/08 | HY-136338 | 西咪替丁亞砜鹽酸鹽 Cimetidine sulfoxide | 54237-72-8 | 5 mg | 1500元 |
| 2025/02/08 | HY-136338 | 西咪替丁亞砜鹽酸鹽 Cimetidine sulfoxide | 54237-72-8 | 10mg | 2400元 |