黃花夾竹桃黃酮
| 中文名稱 | 黃花夾竹桃黃酮 |
|---|---|
| 中文同義詞 | 黃花夾竹桃黃酮;化合物 T13922;芹菜素-5-甲醚 |
| 英文名稱 | Thevetiaflavone |
| 英文同義詞 | 5-O-METHYLAPIGENIN;4',7-Dihydroxy-5-methoxyflavone;Apigenin 5-methylether;7-Hydroxy-2-(4-hydroxyphenyl)-5-methoxy-4H-chromen-4-one;4H-1-Benzopyran-4-one,7-hydroxy-2-(4-hydroxyphenyl)-5-methoxy-;Apigenin 5-O-monomethyl ether;Apigenin-5-methyl ether,5-0-Methylapigenin;Flavone,4',7-dihydroxy-5-methoxy- (8CI) |
| CAS號 | 29376-68-9 |
| 分子式 | C16H12O5 |
| 分子量 | 284.26 |
| EINECS號 | |
| 相關類別 | 黃酮;Miscellaneous Natural Products |
| Mol文件 | Mol File |
| 結構式 |  |
黃花夾竹桃黃酮 性質
| 熔點 | 263℃ |
|---|---|
| 沸點 | 567.9±50.0 °C(Predicted) |
| 密度 | 1.420 |
| 儲存條件 | Store at -20°C |
| 溶解度 | 溶于二甲基亞砜 |
| 酸度系數(shù)(pKa) | 6.67±0.40(Predicted) |
| 形態(tài) | 固體 |
| 顏色 | 淺黃至黃色 |
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Bcl-2
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Bax
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Caspase-3
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Thevetiaflavone, a natural flavonoid obtained from Wikstroemia indica, could improve cell viability and suppresses the leakage of lactate dehydrogenase from the cytoplasm. Further investigation of the mechanisms demonstrated that Thevetiaflavone decreases overproduction of ROS and ameliorates ROS?mediated mitochondrial dysfunction, including collapse of mitochondrial membrane potential and mitochondrial permeability transition pore opening. Thevetiaflavone reduces the intracellular Ca 2+ level, which is closely associated with mitochondrial function and interplays with ROS. Furthermore, Thevetiaflavone inhibits apoptosis in PC12 cells through upregulating the expression of Bcl?2 and downregulating that of Bax and caspase?3 in addition to increasing the activity of caspase?3. These results further indicate the protective effects of thevetiaflavone in vivo and its application in the clinic.