托美丁鈉(二水)
| 中文名稱 | 托美丁鈉(二水) |
|---|---|
| 中文同義詞 | 托美丁鈉二水合物;1-甲基-5-(P-甲苯?；?吡咯-2-乙酸鈉鹽;托美丁鈉(二水);2-[1-甲基-5-(4-甲基苯甲酰)吡咯-2-基]乙酸鈉(二水);托爾米汀鈉;滅定鈉;托美丁鈉 USP標(biāo)準(zhǔn)品;化合物 T2550L |
| 英文名稱 | Sodium tolmetin dihydrate |
| 英文同義詞 | sodiumtolmetindihydrate;tolmetinsodiumdihydrate;1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid sodium-potassium salt dihydrate;TOLMELINSODIUM;Tolmetinsodiumsaltdihydratecrystalline;1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic Acid Sodium Dihydrate;1-Methyl-5-p-toluoylpyrrole-2-acetic Acid Sodium Dihydrate;5-[(p-Tolyl)carbonyl]-1-methylpyrrole-2-acetic Acid Sodium Dihydrate |
| CAS號(hào) | 64490-92-2 |
| 分子式 | C15H14NO3.Na.2H2O |
| 分子量 | 315.3 |
| EINECS號(hào) | 626-708-5 |
| 相關(guān)類別 | 醫(yī)藥中間體;化工中間體;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;BETAGAN;API intermediates |
| Mol文件 | 64490-92-2.mol |
| 結(jié)構(gòu)式 |  |
托美丁鈉(二水) 性質(zhì)
| 熔點(diǎn) | 155-157 (dec.) |
|---|---|
| 儲(chǔ)存條件 | -20°C Freezer |
| 溶解度 | 甲醇（微溶）、水（微溶） |
| 形態(tài) | 固體 |
| 顏色 | 白色至米色 |
| 水溶解性 | Soluble in water |
| InChIKey | QQILXENAYPUNEA-UHFFFAOYSA-M |
| CAS 數(shù)據(jù)庫(kù) | 64490-92-2(CAS DataBase Reference) |
|
Human COX-1 0.35 μM (IC 50 ) |
Human COX-2 0.82 μM (IC 50 ) |
Tolmetin sodium dihydrate (0.25 mM) does not attenuate lipid peroxidation in rat brain homogenate. Tolmetin (0.25, 0.5, 0.75, 1 mM) shows radical scavenging properties but without superoxide anion generation in rat brain homogenat.
Tolmetin sodium dihydrate (0.001-100 μM) shows anticancer activity againts HT-29 colon cancer cell line in a dose-dependent manner.
Tolmetin sodium dihydrate (0-100 μM) shows no effect on osteoblast growth.
Tolmetin sodium dihydrate (30,100 mg/kg; gavage; single dose or twice daily for 3 and 14 days) shows maximal ulcerogenic effect 4 h after the single dose, while potently decreases after 3 and 14 days of repeated administration in male Wistar rats weighing 180-200 g. Tolmetin causes gastric lesions in 100 mg/kg.
Tolmetin sodium dihydrate (5 mg/kg twice a day for 5 days) pre-treatment considerably attenuates quinolinic acid (QA)-induced neurotoxicity.
安全信息
| 提供商 | 語(yǔ)言 |
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英文
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| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2025/02/08 | HY-B1489 | 托美丁鈉(二水) Tolmetin sodium dihydrate | 64490-92-2 | 100mg | 500元 |
| 2025/02/08 | HY-B1489 | 托美丁鈉(二水) Tolmetin sodium dihydrate | 64490-92-2 | 10mM * 1mLin DMSO | 550元 |