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| | (4S)-4-hydroxy-L-proline hydrochloride Basic information |
| Product Name: | (4S)-4-hydroxy-L-proline hydrochloride | | Synonyms: | (4S)-4-hydroxy-L-proline hydrochloride;L-Proline, 4-hydroxy-,hydrochloride, cis-;L-Proline,4-hydroxy-,hydrochloride(1:1),(4S)-;H-cis-Hyp-OH·HCl;cis-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride;(2s,4S)-4-hydroxy-L-proline hydrochloride;Cis-4-hydroxy-L-prolineMonohydrochloride;L-Proline, 4-hydroxy-, hydrochloride, (4S)- | | CAS: | 441067-49-8 | | MF: | C5H10ClNO3 | | MW: | 167.5908 | | EINECS: | 1592732-453-0 | | Product Categories: | | | Mol File: | 441067-49-8.mol |  |
| | (4S)-4-hydroxy-L-proline hydrochloride Chemical Properties |
| storage temp. | Inert atmosphere,Room Temperature | | form | Solid | | color | White to light yellow |
| | (4S)-4-hydroxy-L-proline hydrochloride Usage And Synthesis |
| Uses | cis-4-Hydroxy-L-proline hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). cis-4-Hydroxy-L-proline hydrochloride is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. | | IC 50 | Non-cleavable Linker | | References | [1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. DOI:10.1038/nrd.2016.268
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277 |
| | (4S)-4-hydroxy-L-proline hydrochloride Preparation Products And Raw materials |
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