原蘇木素A
| 中文名稱 | 原蘇木素A |
|---|---|
| 中文同義詞 | 原蘇木素A;原蘇木素A對(duì)照品;原蘇木素A標(biāo)準(zhǔn)品;3,10,11-三羥基-6H-二苯并[B,D]OXOCIN-7(8H)-酮 |
| 英文名稱 | protosappanin A |
| 英文同義詞 | protosappanin A;Sappanol B;3,10,11-Trihydroxy-6H-dibenz[b,d]oxocin-7(8H)-one;PROTOSAPPANIN A (PTA);6H-Dibenz[b,d]oxocin-7(8H)-one, 3,10,11-trihydroxy-;3,10,11-Trihydroxy-6H-dibenzo[b,d]oxocin-7(8H)-one;Protosappanin A,inhibit,JAK,Inhibitor,STAT,Janus kinase |
| CAS號(hào) | 102036-28-2 |
| 分子式 | C15H12O5 |
| 分子量 | 272.25 |
| EINECS號(hào) | |
| 相關(guān)類別 | 對(duì)照品，標(biāo)準(zhǔn)品，含量測(cè)定，藥理研究;標(biāo)準(zhǔn)品-對(duì)照品;標(biāo)準(zhǔn)品，對(duì)照品;對(duì)照品;其它酚類;標(biāo)準(zhǔn)品，對(duì)照品 |
| Mol文件 | 102036-28-2.mol |
| 結(jié)構(gòu)式 |  |
原蘇木素A 性質(zhì)
| 熔點(diǎn) | 254-255 °C |
|---|---|
| 沸點(diǎn) | 613.1±55.0 °C(Predicted) |
| 密度 | 1.476±0.06 g/cm3(Predicted) |
| 儲(chǔ)存條件 | 4°C, away from moisture and light |
| 溶解度 | 溶于二甲基亞砜 |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 9.01±0.20(Predicted) |
| 顏色 | 白色至米白色 |
|
JAK2
|
STAT3
|
Protosappanin A (PTA: 12.5, 25, 50 μM, 24 hours) significantly inhibits the production of TNF-α and IL-1β in LPS-activated BV2 microglia. And the mRNA expressions of IL-6, IL-1β, and MCP-1 are reduced by PTA in a dose-dependent manner in BV2 microglial cell line.
Protosappanin A (PTA: 12.5, 25, 50 μM, 24 hours) suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3, as well as STAT3 nuclear translocation against LPS treatment.
Protosappanin A (PTA: 12.5, 25, 50 μM, 24 hours) shows obvious effect on disturbing the interaction of transmembrane protein CD14 with Toll-like receptor-4, resulting in the inhibition of NF-κB-dependent oxidative and nitrative stress in LPS-induced BV2 microglia.
Western Blot Analysis
| Cell Line: | Murine BV2 microglial cell line. |
| Concentration: | 12.5, 25, 50 μM. |
| Incubation Time: | 24 hours. |
| Result: |
Inhibits the releases of NO, TNF-α and IL-1β in LPS-induced BV2 cells.
Attenuated IL-6, IL-1β and MCP-1 gene expressions in the LPS-induced BV2 cells. Suppressed JAK2/STAT3 pathway activation in the LPS-induced BV2 cells. |
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-113573 | 原蘇木素A Protosappanin A | 102036-28-2 | 1mg | 1100元 |
| 2024/11/08 | HY-113573 | 原蘇木素A Protosappanin A | 102036-28-2 | 5mg | 2800元 |