依氟鳥氨酸鹽酸鹽一水合物
中文名稱 | 依氟鳥氨酸鹽酸鹽一水合物 |
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中文同義詞 | 2-二氟甲基-DL-鳥氨酸鹽酸鹽一水合物;依氟鳥氨酸鹽酸鹽一水合物;鹽酸依氟鳥氨酸一水合物;依氟鳥氨酸鹽酸鹽一水合物99%;鹽酸依氟鳥胺酸;依氟鳥氨酸鹽酸鹽一水物;依氟鳥氨酸鹽酸鹽一水合酸物;2,5-二氨基-2-(二氟甲基)五烯酸鹽酸鹽水合物 |
英文名稱 | Eflornithine hydrochloride hydrate |
英文同義詞 | 2,5-diamino-2-(difluoromethyl)pentanoic acid;DMFO HCl/Eflornithine HCl;DFMO EFLORNITHINE;H-alpha-Difluoro-Me-DL-Orn-OH . HCl . H2O;2-(Difluoromethyl)ornithine hydrochloride hydrate;eflornithine,Eflornithinehydrochloridehydrate;Eflornithine hydrochloride hydrate;Eflornithine hydrochloride monohydrate |
CAS號(hào) | 96020-91-6 |
分子式 | C6H15ClF2N2O3 |
分子量 | 236.64 |
EINECS號(hào) | |
相關(guān)類別 | 脫毛劑;小分子抑制劑;小分子抑制劑,天然產(chǎn)物;醫(yī)藥中間體;藥物成分 (研究實(shí)驗(yàn)用);生發(fā)洗護(hù)系列;化工中間體工業(yè)原料;facial hair remover;Amines;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;進(jìn)口原料;醫(yī)藥原料;有機(jī)中間體 |
Mol文件 | 96020-91-6.mol |
結(jié)構(gòu)式 | ![]() |
依氟鳥氨酸鹽酸鹽一水合物 性質(zhì)
熔點(diǎn) | >210°C (dec.) |
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儲(chǔ)存條件 | Inert atmosphere,2-8°C |
溶解度 | 溶于水(高達(dá) 25 mg/ml)。 |
形態(tài) | 白色粉末 |
顏色 | 白色 |
水溶解性 | water: 1mg/mL methanol: 25mg/mL |
Merck | 14,3522 |
穩(wěn)定性 | 可在-20°下蒸餾水溶液保存長(zhǎng)達(dá)3個(gè)月。 |
CAS 數(shù)據(jù)庫 | 96020-91-6 |
Target | Value |
Orn decarboxylase |
用α-difluoromethyl-Orn處理BY2細(xì)胞,抑制其過氧化氫的產(chǎn)生,但并沒有發(fā)生程序性細(xì)胞死亡。
Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension.
安全信息
RTECS號(hào) | RM2981900 |
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海關(guān)編碼 | 2922493800 |
更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
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2025/02/08 | HY-B0744B | 依氟鳥氨酸鹽酸鹽一水合物 Eflornithine hydrochloride hydrate | 96020-91-6 | 100mg | 500元 |
2025/02/08 | HY-B0744B | 依氟鳥氨酸鹽酸鹽一水合物 Eflornithine hydrochloride hydrate | 96020-91-6 | 10mM * 1mLin Water | 550元 |