C-GPAP
| 中文名稱 | C-GPAP |
|---|---|
| 中文同義詞 | CGAMP銨鹽;CGAMP 鈉鹽;CGAMP游離態(tài);2-氨基-9-((2R,3R,3AS,7AR,9R,10R,10AS,14AR)-9-(6-氨基-9H-嘌呤-9-基)-3,5,10,12-四羥基-5,12-DIOXIDOOCTAHYDRO-2H,7H-二呋喃[3,2-D:3',2'-J][1,3,7,9]四氧雜[2,8]二磷酸環(huán)十二烯-2-基)-3,9-二氫-6H-嘌呤-6-酮;2-氨基-9-((2R,3R,3AS,7AR,9R,10R,10AS,14AR)-9-(6-氨基-9H-嘌呤-9-基)-3,5,10,12-四羥基-5,12-DIOXIDOOCTAHYDRO-2H,7H-二呋喃[3,2-D:3',2'-J][1,3,7,9]四氧雜[2,8]二磷酸環(huán)十二烯-2-基)-3,9-二氫-6H-嘌呤-6-酮;糖蛋白AP;CGAMP 鈉鹽,STING激動(dòng)劑 |
| 英文名稱 | c-GpAp |
| 英文同義詞 | c-GpAp;di-GAMP;di-cGAMP;cGAMP;3'3'-cGAMP;cGAMP (Cyclic GMP-AMP;3''-Guanylic acid, adenylyl-(3''?5'')-, cyclic nucleotide;3',3'-Cyclic guanosine monophosphate-adenosine monophosphate |
| CAS號(hào) | 849214-04-6 |
| 分子式 | C20H24N10O13P2 |
| 分子量 | 674.41 |
| EINECS號(hào) | |
| 相關(guān)類別 | 生物活性分子-API;活性分子;干擾素誘導(dǎo)物;對(duì)照品;Nucleotides, Bases & Related Reagents, Derivatives |
| Mol文件 | 849214-04-6.mol |
| 結(jié)構(gòu)式 |  |
C-GPAP 性質(zhì)
| 沸點(diǎn) | 1159.9±75.0 °C(Predicted) |
|---|---|
| 密度 | 2.61±0.1 g/cm3(Predicted) |
| 儲(chǔ)存條件 | -20°C |
| 酸度系數(shù)(pKa) | 0.96±0.70(Predicted) |
| 形態(tài) | 粉末 |
| 顏色 | 白色至米色 |
| 水溶解性 | Water : 20 mg/mL (29.66 mM) |
3',3'-cGAMP (3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP)可激活內(nèi)質(zhì)網(wǎng)(ER)內(nèi)源性受體 stimulator of interferon genes (STING) ，從而誘導(dǎo)抗病毒狀態(tài)和I型IFN的分泌。
| Target | Value |
|
STING
() |
cGAMP promotes the antigen-specific proliferation capacity of spleen cells in mice.
cGAMP directly activates murine and human dendritic cells in vitro.
On stimulation with cGAMP, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding interleukin-1 (IL1), interleukin-6 (IL6), or tumor necrosis factor (TNF).
cGAMP activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs.
cGAMP promotes the antigen-specific cytokine production by spleen cells of immunized mice.
| Animal Model: | Female C57BL/6 (H-2b) mice 6–8 weeks old |
| Dosage: | 5 μg |
| Administration: | Nostril mucosal adjuvant |
| Result: | Higher titers of ovalbumin (OVA)-specific IgA and total IgG as well as IgG1 and IgG2c in the sera of mice immunized with cGAMP-adjuvanted OVA as compared to sera from OVA-immunized mice. |
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2024/11/08 | S7905 | C-GPAP 3',3'-cGAMP | 849214-04-6 | 1mg | 3900元 |
| 2024/11/08 | S7905 | 3',3'-cGAMP | 5mg | 7944.3元 |