10-羥基喜樹堿
| 中文名稱 | 10-羥基喜樹堿 |
|---|---|
| 中文同義詞 | 10-羥基喜樹堿;10-(±)羥基喜樹堿標準品;10-羥基喜樹堿(CAS號:64439-81-2);160177;4-乙基-4,9-二羥基-1H-吡喃并[3',4':6,7]吲哚并[1,2-B]喹啉-3,14(4H,12H)-二酮;10-(±)羥基喜樹堿;10-輕基喜樹堿;(鹵)-10-HYDROXYCAMPTOTHECIN |
| 英文名稱 | 10-Hydroxycamptothecin |
| 英文同義詞 | 10-HYDROXYCAMPTOTHECIN ACETATE;10-HYDROXYCAMPTOTHECIN ACETATE SALT;7-ETHYL-10-HYDROXY CAMPTHOTECIN;Hydroxy Camptothecine;77-Ethyl-10-hydroxy campthotecin;(20S)- 7-Ethyl-10-Hydroxycamptothecin;10-Hydroxycamp-totecin;7ETHYHYDROXYCAMPTOTHECIN |
| CAS號 | 64439-81-2 |
| 分子式 | C20H16N2O5 |
| 分子量 | 364.35 |
| EINECS號 | 613-598-9 |
| 相關(guān)類別 | 醫(yī)藥中間體;其它有機試劑;對照品,標準品;小分子抑制劑;小分子抑制劑，天然產(chǎn)物;原料藥;Antineoplastic;Camptothecin series;喜樹堿系列;Inhibitors;原料;醫(yī)藥、農(nóng)藥及染料中間體;植物提取;通用生化試劑-天然產(chǎn)物;科研原料;化學試劑 |
| Mol文件 | 64439-81-2.mol |
| 結(jié)構(gòu)式 |  |
10-羥基喜樹堿 性質(zhì)
| 熔點 | 230-237°C |
|---|---|
| 沸點 | 820.7±65.0 °C(Predicted) |
| 密度 | 1.60 |
| 儲存條件 | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| 溶解度 | 二甲基亞砜：≥37.5 mg/ml（102.92mM） |
| 形態(tài) | 淡黃色粉末 |
| 酸度系數(shù)(pKa) | 8.93±0.40(Predicted) |
| 顏色 | 粘黃色 |
| InChI | InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3 |
| InChIKey | LCZZWLIDINBPRC-FQEVSTJZSA-N |
| SMILES | N1C2C(=CC(O)=CC=2)C=C2CN3C(C=12)=CC1C(CC)(O)C(=O)OCC=1C3=O |
| CAS 數(shù)據(jù)庫 | 64439-81-2(CAS DataBase Reference) |
| Target | Value |
|
DNA topoisomerase I
() |
(±)-10-Hydroxycamptothecin (10-OH-camptothecin) is an inhibitor of topo I. (±)-10-Hydroxycamptothecin (10-HCPT, 5-20 nM) markedly inhibits the proliferation of Colo 205 cells in a dose-dependent manner. (±)-10-Hydroxycamptothecin (5-20 nM) arrests Colo 205 cells in the G2 phase of the cell cycle and triggers apoptosis through a caspase-3-dependent pathway. (±)-10-Hydroxycamptothecin (HPT, 0.01-10 μg/mL) causes cell shrinage, nuclear fragmentation and condensed chromosomes and induces apoptosis of human urinary bladder cancer cell line (T24).
(±)-10-Hydroxycamptothecin (10-HCPT, 2.5-7.5 mg/kg/2 days, p.o.) significantly suppresss tumor growth in mouse xenografts. (±)-10-Hydroxycamptothecin (1-7.5 mg/kg, p.o., once per 2 or 4 days) causes no obvious acute toxicity in nude mice.
安全信息
| 危險品標志 | Xi,T |
|---|---|
| 危險類別碼 | 36/37/38-25 |
| 安全說明 | 26-36-45 |
| 危險品運輸編號 | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
| RTECS號 | UQ0491000 |
| 提供商 | 語言 |
|---|---|
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英文
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| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2025/02/05 | S3898 | 10-羥基喜樹堿 Hydroxy Camptothecine | 64439-81-2 | 25mg | 794.43元 |
| 2023/01/06 | XW196850971 | 10-羥基喜樹堿 | 1g | 493元 |