H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH
| 中文名稱 | H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH |
|---|---|
| 中文同義詞 | LARAZOTIDE ACETATE (> 90%);2-((S)-1-((2S,5S,8S,11S)-17-氨基-2-(3-氨基-3-氧代丙基)-8-異丁基-5,11-二異丙基-4,7,10,13,16-五氧代-3,6,9,12,15-五氮雜十七烷-1-?；?吡咯烷-2-羧酰胺基)乙酸 乙酸鹽;化合物L(fēng)ARAZOTIDE ACETATE;拉瑞唑來乙酸鹽;2-((S)-1-((2S,5S,8S,11S)-17-氨基-2-(3-氨基-3-氧代丙基)-8-異丁基-5,11-二異丙基-4,7,10,13,16-五氧代-3,6,9,12,15-五氮雜十七烷-1-?；?吡咯烷-2-羧酰胺基)乙酸 乙酸;拉雷佐肽 |
| 英文名稱 | Larazotide |
| 英文同義詞 | H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH;LARAZOTIDE ACETATE (> 90%);Larazotide acetate;inhibit,Larazotide acetate,Larazotide,Inhibitor,Gap Junction Protein;Larazotide acetate salt;AT-1001 (Larazotide acetate) |
| CAS號 | 881851-50-9 |
| 分子式 | C34H59N9O12 |
| 分子量 | 785.88536 |
| EINECS號 | |
| 相關(guān)類別 | 定制肽;多肽中間體 |
| Mol文件 | 881851-50-9.mol |
| 結(jié)構(gòu)式 |  |
H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH 性質(zhì)
| 熔點 | >231°C (dec.) |
|---|---|
| 儲存條件 | Refrigerator |
| 溶解度 | 可微溶于水 |
| 形態(tài) | 固體 |
| 顏色 | 白色 |
Paracellular permeability
Larazotide acetate inhibits the redistribution and rearrangement of zonula occludens-1 (ZO-1) and actin caused by AT-1002 and gliadin fragments in Caco-2 and IEC6 cells. Larazotide acetate inhibits the AT-1002-induced TEER reduction and TJ opening in Caco-2 cells. Larazotide acetate inhibits the translocation of a gliadin 13-mer peptide, which has been implicated in celiac disease, across Caco-2 cell monolayers. Further, apically applied Larazotide acetate inhibits the increase in TJ permeability elicited by basolaterally applied cytokines.
When tested in vivo in gliadin-sensitized HLA-HCD4/DQ8 double transgenic mice, larazotide acetate inhibits gliadin-induced macrophage accumulation in the intestine and preserved normal tight junction structure.
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2025/02/08 | HY-106268A | H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH Larazotide acetate | 881851-50-9 | 1mg | 700元 |
| 2025/02/08 | HY-106268A | H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH Larazotide acetate | 881851-50-9 | 5mg | 1100元 |