成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

AVE 0991

AVE 0991

中文名稱AVE 0991
中文同義詞ANG-(1-7)激動劑(AVE 0991);N-(乙基氨甲酰)-3-(4-((5-甲?;?4-甲氧基-2-苯基-1H-咪唑-1-基)甲基)苯基)-5-異丁基噻吩-2-磺酰胺;化合物AVE 0991;化合物AVE0991,10 MM DMSO 溶液
英文名稱AVE0991
英文同義詞AVE0991;N-[(Ethylamino)carbonyl]-3-[4-[(5-formyl-4-methoxy-2-phenyl-1H-imidazol-1-yl)methyl]phenyl]-5-(2-methylpropyl)-2-thiophenesulfonamide;2-Thiophenesulfonamide, N-[(ethylamino)carbonyl]-3-[4-[(5-formyl-4-methoxy-2-phenyl-1H-imidazol-1-yl)methyl]phenyl]-5-(2-methylpropyl)-;N-(Ethylcarbamoyl)-3-(4-((5-formyl-4-methoxy-2-phenyl-1H-imidazol-1-yl)methyl)phenyl)-5-isobutylthiophene-2-sulfonamide;AVE 0991, 10 mM in DMSO
CAS號304462-19-9
分子式C29H32N4O5S2
分子量580.72
EINECS號
相關類別細胞生物學試劑
Mol文件304462-19-9.mol
結(jié)構(gòu)式AVE 0991 結(jié)構(gòu)式

AVE 0991 性質(zhì)

熔點191-192℃
密度1.31±0.1 g/cm3(Predicted)
儲存條件under inert gas (nitrogen or Argon) at 2–8 °C
溶解度DMSO 中≥29.04 mg/mL
形態(tài)固體
酸度系數(shù)(pKa)5.12±0.10(Predicted)
顏色米白色至黃色

AVE 0991 用途與合成方法

AVE 0991 是一種有效的非肽Ang-(1-7) 受體 Mas 激動劑。AVE 0991 與 [125I]-Ang-(1-7) 競爭性地結(jié)合到牛主動脈內(nèi)皮細胞膜,IC50 為 21 nM。

IC50: 21±35 nM (Ang-(1-7) receptor)

AVE 0991 is a nonpeptide compound that evokes effects similar to Ang-(1-7) on the endothelium. AVE 0991 and unlabeled Ang-(1-7) compete for high-affinity binding of [ 125 I]-Ang-(1-7) to bovine aortic endothelial cell membranes with IC 50 s of 21±35 and 220±280 nM, respectively. Peak concentrations of NO and O 2 - release by AVE 0991 sodium salt and Ang-(1-7) (both 10 μM) are not significantly different (NO: 295±20 and 270±25 nM; O 2 - : 18±2 and 20±4 nM). However, the released amount of bioactive NO is ≈5 times higher for AVE 0991 in comparison to Ang-(1-7).

AVE 0991 (0.58 nmol/g) produces a significant decrease of water diuresis in WT mice compared with vehicle-treated animals (0.06±0.03 mL versus 0.27±0.05; n=9 for each group; P<0.01). The antidiuretic effect of AVE 0991 (AVE) is associated with an increase in urine osmolality (1669±231.0 mOsm/KgH 2 O versus 681.1±165.8 mOsm/KgH 2 O in vehicle-treated mice; P<0.01). The genetic deletion of Mas abolishes the antidiuretic effect of AVE 0991 during water loading (0.37±0.10 mL [n=9] versus 0.27±0.03 mL [n=11] in AVE 0991-treated mice). As observed with C57BL/6 mice, administration of AVE 0991 (0.58 nmol/g) in water-loaded Swiss mice also produces a significant decrease of the urinary volume compared with vehicle-treated animals (0.13±0.05 mL [n=16] versus 0.51±0.04 mL [n=40]; P<0.01). One week of treatment with AVE-0991 produces a significant decrease in perfusion pressure (56.55±0.86 vs. 68.73±0.69 mmHg in vehicle-treated rats) and an increase in systolic tension (11.40±0.05 vs. 9.84±0.15 g in vehicle-treated rats), rate of tension rise (+dT/dt; 184.30±0.50 vs. 155.20±1.97 g/s in vehicle-treated rats), rate of tension fall (?dT/dt; 179.60±1.39 vs. 150.80±2.42 g/s in vehicle-treated rats). A slight increase in heart rate (HR) is also observed (220.40±0.71 vs. 214.20±0.74 beats/min in vehicle-treated rats.

安全信息

MSDS信息

更新日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2025/02/08HY-15778AVE 0991
AVE 0991
304462-19-92mg950元
2025/02/08HY-15778AVE 0991
AVE 0991
304462-19-95mg1900元

AVE 0991 上下游產(chǎn)品信息

"AVE 0991"相關產(chǎn)品信息
主頁 | 企業(yè)會員服務 | 廣告業(yè)務 | 聯(lián)系我們 | 舊版入口 | 中文MSDS | CAS Index | 常用化學品CAS列表 | 化工產(chǎn)品目錄 | 新產(chǎn)品列表 | 評選活動 | HS海關編碼 | MSDS查詢 | 化工站點

Copyright © 2016-2023 ChemicalBook 版權所有  京ICP備07040585號  京公海網(wǎng)安備11010802032676號  

互聯(lián)網(wǎng)增值電信業(yè)務經(jīng)營許可證:京ICP證150597號  互聯(lián)網(wǎng)藥品信息服務資格證編號(京)-非經(jīng)營性-2015-0073  信息系統(tǒng)安全等級保護備案證明(三級)  營業(yè)執(zhí)照公示

本網(wǎng)站展示的所有產(chǎn)品僅用于工業(yè)應用或者科學研究等非醫(yī)療目的,不可用于人類或動物的臨床診斷或者治療,非藥用,非食用。
根據(jù)相關法律法規(guī)和本站規(guī)定,單位或個人購買相關危險物品應取得有效的資質(zhì)、資格條件。

參考《應急管理部等多部門關于加強互聯(lián)網(wǎng)銷售危險化學品安全管理的通知 (應急〔2022〕119號)》《互聯(lián)網(wǎng)危險物品信息發(fā)布管理規(guī)定》