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Standard

In the analysis work, it often demanded to apply high-quality compound with the exact content being accurate in order to be compared as the detection control or used to calibrate the instrument, the compound is known as standard sample.
Standard refers to the standard substance used for measuring the potency of biological products. When the production department submits to a higher authority for approval of the quality standard of the biological product, they should also provide the standard sample (indicated in unit (μ)) used for measuring the potency of the tested product.

According to different application, the verification products can be divided into biological standard for the testing of biological products, endocrine drugs, antibiotics and other bioassay and chemical standards including:
1 chemical standards used for calibration of the instrument;
2 chemical reference standards used for calibration of the ultraviolet or infrared spectrum of the drugs;
3 control standards used for the purity test of drugs as well as the impurity control or as the control standards for content determination of the medicine.

In the page 67 of the appendix in the People's Republic of China Pharmacopoeia 1990 1st edition, we can find hundreds kinds of standards including bornyl ester acetate, eugenol and panaxadiol as well as 39 kinds of control medicine for the purify inspection of traditional Chinese medicine, impurity control or the content determination.

International standards
This refers to standard sample, with the potency units of the existing international standard sample potency units as baseline, undergoing further calibration of its potency units on the basis of a wide range of international cooperation. Its potency is expressed in 1U. For a certain product, for the establishment of the first international standard sample, the determination of its potency units should be consulted and decided by the Committee of Experts before the announcement. The international standard is a standard reference substance for worldwide preparation of national standards, so that the international standards can achieve unity.

Reagents and standards
All reagents in the food analysis laboratories should be clearly labeled to indicate the following: 1 name; 2 the date of preparation; 3 Signature from the people in charge; 4 if necessary, we need to add content such as safety and validity and so on.
Most food analysis should use standard sample as reference for qualitative and quantitative determination. The standard sample should be classified according to the following classification methods: 1 international standard; 2 national standards; 3 internal standard; 4 other standards.
Receptacle for reference standards should be clearly affixed to the label, to indicate the following: 1 name; 2 standard document number; 3 Opening times; 4 Validity; 5 Signature.
In addition, the laboratory should keep all the necessary specific files for all the necessary reference standards.
Capacity analysis standard solution should also be strictly managed. It should be clearly posted on all the standard solution containers with labels to indicate: 1 name; 2 concentration; 3 formulation date; 4 No of formulated procedures; 5 storage conditions; 6 validity; 7 Signature from people in charge.

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Structure Chemical Name CAS MF
Brivaracetam Impurity 16 Brivaracetam Impurity 16
Etoricoxib Impurity 41 Etoricoxib Impurity 41 855307-80-1 C18H13ClN2O2S
Fluvoxamine Impurity 10 Fluvoxamine Impurity 10
Nintedanib Impurity 50 Nintedanib Impurity 50 2410284-90-9 C56H52N8O8
Olopatadine Impurity 8 Olopatadine Impurity 8
Oseltamivir Impurity 36 Oseltamivir Impurity 36
Palbociclib Impurity 61 Palbociclib Impurity 61 2222404-53-5 C14H20N4O4
Palbociclib Impurity 41 Palbociclib Impurity 41
Saxagliptin Impurity 8 Saxagliptin Impurity 8
Tenofovir Impurity 63 Tenofovir Impurity 63
Ticagrelor Impurity 99 Ticagrelor Impurity 99
Ticagrelor Impurity 114 Ticagrelor Impurity 114
Ticagrelor Impurity 98 Ticagrelor Impurity 98
Tofacitinib Impurity 118 Tofacitinib Impurity 118
Trelagliptin Impurity 23 Trelagliptin Impurity 23
Vildagliptin Impurity 33 Vildagliptin Impurity 33
Vildagliptin Impurity 44 Vildagliptin Impurity 44
Voriconazole Impurity 16 Voriconazole Impurity 16 1157981-64-0 C10H7F2N3O
CLOZAPINE-D3 CLOZAPINE-D3 1215691-72-7 C18H19ClN4
Levofloxacin Impurity 23 Levofloxacin Impurity 23 2206825-95-6 C19H21ClFN3O4
Nitrendipine impurity 1 Nitrendipine impurity 1 1242511-98-3 C18H18N2O5
methyl 7-bromo-4-hydroxyisoquinoline-3-carboxylate methyl 7-bromo-4-hydroxyisoquinoline-3-carboxylate 1572439-66-7 C11H8BrNO3
Dapoxetine impurity Dapoxetine impurity 2242008-36-0 C28H26O3
Pregabalin Impurity 11 Pregabalin Impurity 11 177432-20-1 C7H11NO3
Pregabalin Impurity 6 Pregabalin Impurity 6 2102350-92-3 C9H15NO3
Sunitinib Impurity 2 Sunitinib Impurity 2
(2S,3R,4R,5S,6R)-2-(3-(4-ethoxybenzyl)phenyl)-6-(hydroxyl methyl)tetrahydro-2H-pyran-3,4,5-triol (2S,3R,4R,5S,6R)-2-(3-(4-ethoxybenzyl)phenyl)-6-(hydroxyl methyl)tetrahydro-2H-pyran-3,4,5-triol 2452300-89-7 C21H26O6
Amlodipine Impurity 23 (E-Isomer) Amlodipine Impurity 23 (E-Isomer) C26H31ClN2O8S
Axitinib Impurity 12 Axitinib Impurity 12
Axitinib Impurity 17 Axitinib Impurity 17
Erlotinib Impurity 37 Erlotinib Impurity 37
Itraconazole iMpurity 3 Itraconazole iMpurity 3
1-(3,5-bis(benzyloxy)phenyl)-2,2-dibromoethan-1-one 1-(3,5-bis(benzyloxy)phenyl)-2,2-dibromoethan-1-one C22H18Br2O3
Axitinib Impurity 8 Axitinib Impurity 8
Agomelatine Impurity 11 Agomelatine Impurity 11
Saxagliptin Impurity 7 Saxagliptin Impurity 7
Cinacalcet Impurity 23 Cinacalcet Impurity 23
Erlotinib Impurity 24 Erlotinib Impurity 24
Ticagrelor Impurity 47 Ticagrelor Impurity 47
Edaravone Impurity 10 Edaravone Impurity 10
Empagliflozin Impurity 10 Empagliflozin Impurity 10
Canagliflozin Impurity 10 Canagliflozin Impurity 10
Rivaroxaban Impurity 35 Rivaroxaban Impurity 35
Febuxostat Impurity 67 Febuxostat Impurity 67
Hydroxytyrosol 4-O-glucoside Hydroxytyrosol 4-O-glucoside 54695-80-6 C14H20O8
Riociguat IMpurtiy A Riociguat IMpurtiy A
Peramivir Impurity C Peramivir Impurity C
Lincomycin sulfoxide Impurity 6 Lincomycin sulfoxide Impurity 6
Metronidazole IMpurity 5 Metronidazole IMpurity 5
Sulpiride Impurity 5 Sulpiride Impurity 5
methyl 3-(4-(3-(ethylamino)-2-hydroxypropoxy)phenyl)propanoate  hydrochloride methyl 3-(4-(3-(ethylamino)-2-hydroxypropoxy)phenyl)propanoate hydrochloride C15H24ClNO4
Tacrolimus Impurity F Tacrolimus Impurity F
Cefminox Impurity E Cefminox Impurity E
Bumetanide iMpurity F Bumetanide iMpurity F
(R)-Zanubrutinib (R)-Zanubrutinib 1691249-44-1 C27H29N5O3
LUMAT-005 LUMAT-005 313369-16-3 C16H19N3O3
Fimasartan Impurity F Fimasartan Impurity F
Gefitinib impurity M Gefitinib impurity M
Linagliptin Impurity CD10088 Linagliptin Impurity CD10088
Tacrolimus Ring-opening Impurity Tacrolimus Ring-opening Impurity 1393890-33-9 C44H69NO12
Tadalafil Impurity 35 Tadalafil Impurity 35 749864-17-3 C20H18N2O4
HYDROXYZINE HYDROCHLORIDE HYDROXYZINE HYDROCHLORIDE C21H28Cl2N2O2
Epinastine Impurity 1 HCl Epinastine Impurity 1 HCl 141342-71-4 C15H15N3O2
Flurbiprofen Impurity 5 Flurbiprofen Impurity 5 124635-84-3 C18H19FO4
Azacitidine Impurity 31 Azacitidine Impurity 31 65024-85-3 C11H16O8
Diazepam Impurity 3 Diazepam Impurity 3 176796-46-6 C17H17ClN2O2
Pitavastatin Impurity 19 Sodium Salt Pitavastatin Impurity 19 Sodium Salt 1980814-87-6 C25H24FNO5
N-(4-(4-fluorophenyl)-5-((E)-2-((2R,4R)-4-hydroxy-6- oxotetrahydro-2H-pyran-2-yl)vinyl)-6-isopropylpyrimidin- 2-yl)-N-methylmethanesulfonamide N-(4-(4-fluorophenyl)-5-((E)-2-((2R,4R)-4-hydroxy-6- oxotetrahydro-2H-pyran-2-yl)vinyl)-6-isopropylpyrimidin- 2-yl)-N-methylmethanesulfonamide C22H26FN3O5S
N-Depiperidin-3-amine Linagliptin Dimer N-Depiperidin-3-amine Linagliptin Dimer 2253964-98-4 C45H44N14O4
(1R,5R,6S)-5-Hydroxy-7-oxabicyclo[4.1.0]hept-2-ene-3-carboxylic Acid Ethyl Ester (1R,5R,6S)-5-Hydroxy-7-oxabicyclo[4.1.0]hept-2-ene-3-carboxylic Acid Ethyl Ester 1476028-68-8 C9H12O4
(8S,11S,Z)-5-(2-Aminothiazol-4-yl)-11-(3-guanidinopropyl)-2,2-dimethyl-6,9-dioxo-8-((S)-1-(sulfoamino)ethyl)-3-oxa-4,7,10-triazadodec-4-ene-1,12-dioic Acid (8S,11S,Z)-5-(2-Aminothiazol-4-yl)-11-(3-guanidinopropyl)-2,2-dimethyl-6,9-dioxo-8-((S)-1-(sulfoamino)ethyl)-3-oxa-4,7,10-triazadodec-4-ene-1,12-dioic Acid C19H31N9O10S2
Brepperazole impurity Brepperazole impurity
Mupirocin iMpurity 4 Mupirocin iMpurity 4 C26H44O9
Tenofovirdisoproxil Impurity C Tenofovirdisoproxil Impurity C 1878175-82-6 C11H17N5O2
Cytarabine Impurity 13 Cytarabine Impurity 13 82855-62-7 C17H19N5O8
2052297-80-8 2052297-80-8 2052297-80-8 C12H21NO3
Pramipexole Impurity L Pramipexole Impurity L
1020151-61-4 1020151-61-4 1020151-61-4 C14H23ClO3S
Nicergoline Impurity M Nicergoline Impurity M
Apixaban Impurity 48 Apixaban Impurity 48
ethyl 2-(4-(tert-butoxy)-3-cyanophenyl)-4-methylthiazole-5- carboxylate ethyl 2-(4-(tert-butoxy)-3-cyanophenyl)-4-methylthiazole-5- carboxylate C18H20N2O3S
(trans)-phenyl 3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4'-fluoro- [1,1'-biphenyl]-4-yl)piperidine-1-carboxylate (trans)-phenyl 3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4'-fluoro- [1,1'-biphenyl]-4-yl)piperidine-1-carboxylate C32H28FNO5
Moxifloxacin Impurity 9 Moxifloxacin Impurity 9
Ticagrelor Impurity 10 Ticagrelor Impurity 10
Tofacitinib Impurity O Tofacitinib Impurity O
Celecoxib Impurity 5 Celecoxib Impurity 5 C17H14F3N3O2S
Prasugrel Impurity 10 Prasugrel Impurity 10
Amlodipine N-Lactoside Amlodipine N-Lactoside 749864-27-5 C32H45ClN2O15
Sugammadex Impurity 19 Sugammadex Impurity 19 2379877-89-9
Apixaban Impurity 29 Apixaban Impurity 29
Alogliptin Impurity 22 Alogliptin Impurity 22
Ritonavir Impurity Ritonavir Impurity 1414933-89-3 C23H32N2O3
Riociguat Impurity 7 Riociguat Impurity 7
Tacrolimus Impurity 5 Tacrolimus Impurity 5 161861-18-3 C44H67NO12
monocalciummono(4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5- methoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate) monocalciummono(4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5- methoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate) C23H26CaNO5
Aprepitant iMpurity 38 Aprepitant iMpurity 38
Aprepitant iMpurity 41 Aprepitant iMpurity 41
(E)-3'-(2-(1-(3,4-dimethylphenyl) (E)-3'-(2-(1-(3,4-dimethylphenyl)
Tenofovir Tenofovir 34956-22-4 C14H23O6PS
Afatinib Impurity YHQ Afatinib Impurity YHQ
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