| Identification | More | [Name]
2-(Hydroxymethyl)pyridine | [CAS]
586-98-1 | [Synonyms]
2-HMP
2-(HYDROXYMETHYL)PYRIDINE
2-PICOLYL ALCOHOL
2-PYRIDINEMETHANOL
2-PYRIDINYLMETHANOL
2-PYRIDYLCARBINOL
2-PYRIDYLMETHANOL
OMEGA-HYDROXY-2-PICOLINE
PYRIDIN-2-YL-METHANOL
PYRIDINE-2-METHANOL
RARECHEM AL BD 0182
TIMTEC-BB SBB004348
alpha-Picolyl alcohol
alpha-picolylalcohol
Piconol
Pyridine-2-carbinol
picolinyl alcohol
2-Hydromethyl Pyridine
2-Hydroxymethyl pyrdine
Pyridine-2-methanol,98+% | [EINECS(EC#)]
209-592-7 | [Molecular Formula]
C6H7NO | [MDL Number]
MFCD00006348 | [Molecular Weight]
109.13 | [MOL File]
586-98-1.mol |
| Chemical Properties | Back Directory | [Appearance]
CLEAR COLORLESS TO YELLOW OR BROWN LIQUID | [Melting point ]
5 °C
| [Boiling point ]
112-113 °C/16 mmHg (lit.) | [density ]
1.131 g/mL at 25 °C(lit.)
| [vapor pressure ]
3.47Pa at 25℃ | [refractive index ]
n20/D 1.543(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
2-8°C
| [solubility ]
miscible | [form ]
Liquid | [pka]
13.48±0.10(Predicted) | [color ]
Clear colorless to yellow or brown | [Specific Gravity]
1.131 | [Odor]
pyridine odor | [PH]
6-8 (100g/l, H2O, 20℃) | [Water Solubility ]
miscible | [Sensitive ]
Hygroscopic | [BRN ]
107849 | [InChIKey]
SHNUBALDGXWUJI-UHFFFAOYSA-N | [LogP]
0.11 | [CAS DataBase Reference]
586-98-1(CAS DataBase Reference) | [NIST Chemistry Reference]
Piconol(586-98-1) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R22:Harmful if swallowed. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [RTECS ]
UT4689000
| [F ]
3-8 | [Hazard Note ]
Irritant/Keep Cold/Hygroscopic | [HazardClass ]
IRRITANT, HYGROSCOPIC, KEEP COLD | [HS Code ]
29333999 |
| Hazard Information | Back Directory | [Chemical Properties]
CLEAR COLORLESS TO YELLOW OR BROWN LIQUID | [Uses]
A pyridylalcohol with hypoglycemic activity and potential apoptotic effect in human leukemia cells. | [Uses]
decongestant | [Definition]
ChEBI: 2-Pyridinylmethanol is a member of pyridines. | [Preparation]
The preparation of 2-(Hydroxymethyl)pyridine is as follows:NaOH (0.5 g, 12.5 mmol), Al2O3 (2.0 g, 19.6 mmol), aldehyde 1f-g (2 mmol) and H2O (400 μL) were grinded in a mortar. Next, the paste were placed in a glass 10 mL pressure vials and reaction was carried out in microwave reactor: standard mode (200 W), 100 °C, 2 min. After that, reaction mixture was extracted with DCM (2 × 20 mL). Organic layer was evaporated under reduce pressure yielding 2f-g. Solid residue was washed by water (2 × 15 mL). Aqueous phase was acidify with 1N HCl to pH 5.5 and centrifuged. After that aqueous layer was pour down and precipitate was lyophilisated. Products 3f-g were obtained as white solids.
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