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ChemicalBook >> CAS DataBase List >> WZ4002

WZ4002

WZ4002 price.
  • $28 - $4050
  • Product name: WZ4002
  • CAS: 1213269-23-8
  • MF: C25H27ClN6O3
  • MW: 494.97
  • EINECS:206-141-6
  • MDL Number:MFCD16621244
  • Synonyms:WZ4002;N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide;N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide;WZ4002(HBr);N-{3-[(5-Chloro-2-{[2-Methoxy-4-(4-Methyl-1-piperazinyl)phenyl]aMino}-4-pyriMidinyl)oxy]phenyl}acrylaMide;N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide WZ 4002;WZ 4002 N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide;N-[3-[5-chloro-2-[2-Methoxy-4-(4-Methylpiperazin-1-yl)anilino]pyriMidin-4-yl]oxyphenyl]prop-2-enaMide
28 prices
Selected condition：
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Sigma-Aldrich
  • TRC
Package
  • 100mg
  • 250mg
  • 1g
  • 5g
  • 10mM(in 1mL DMSO)
  • 1unit
  • 5mg
  • 10MG
  • 50MG
  • ManufacturerAK Scientific
  • Product numberX7482
  • Product descriptionWZ4002
  • Packaging5mg
  • Price$47
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0004448
  • Product descriptionWZ-4002 95.00%
  • Packaging5MG
  • Price$192.5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0004448
  • Product descriptionWZ-4002 95.00%
  • Packaging10MG
  • Price$226.8
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0004448
  • Product descriptionWZ-4002 95.00%
  • Packaging50MG
  • Price$981.75
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1389
  • Product descriptionWZ4002
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1389
  • Product descriptionWZ4002
  • Packaging10mM(in 1mL DMSO)
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1389
  • Product descriptionWZ4002
  • Packaging10mg
  • Price$85
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1389
  • Product descriptionWZ4002
  • Packaging50mg
  • Price$260
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1389
  • Product descriptionWZ4002
  • Packaging100mg
  • Price$470
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60094
  • Product descriptionWZ4002 ≥98%
  • Packaging10mg
  • Price$168
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180821
  • Product descriptionWZ4002 >99%
  • Packaging100mg
  • Price$414.8
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180821
  • Product descriptionWZ4002 >99%
  • Packaging250mg
  • Price$555.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180821
  • Product descriptionWZ4002 >99%
  • Packaging1g
  • Price$1060.8
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16297
  • Product descriptionWZ4002 ≥98%
  • Packaging5mg
  • Price$62
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16297
  • Product descriptionWZ4002 ≥98%
  • Packaging10mg
  • Price$109
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16297
  • Product descriptionWZ4002 ≥98%
  • Packaging50mg
  • Price$419
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X7482 WZ4002 5mg $47 2021-12-16 Buy
American Custom Chemicals Corporation INB0004448 WZ-4002 95.00% 5MG $192.5 2021-12-16 Buy
American Custom Chemicals Corporation INB0004448 WZ-4002 95.00% 10MG $226.8 2021-12-16 Buy
American Custom Chemicals Corporation INB0004448 WZ-4002 95.00% 50MG $981.75 2021-12-16 Buy
ApexBio Technology A1389 WZ4002 1unit $28 2021-12-16 Buy
ApexBio Technology A1389 WZ4002 10mM(in 1mL DMSO) $75 2021-12-16 Buy
ApexBio Technology A1389 WZ4002 10mg $85 2021-12-16 Buy
ApexBio Technology A1389 WZ4002 50mg $260 2021-12-16 Buy
ApexBio Technology A1389 WZ4002 100mg $470 2021-12-16 Buy
Arctom CFN60094 WZ4002 ≥98% 10mg $168 2021-12-16 Buy
Biorbyt Ltd orb180821 WZ4002 >99% 100mg $414.8 2021-12-16 Buy
Biorbyt Ltd orb180821 WZ4002 >99% 250mg $555.9 2021-12-16 Buy
Biorbyt Ltd orb180821 WZ4002 >99% 1g $1060.8 2021-12-16 Buy
Cayman Chemical 16297 WZ4002 ≥98% 5mg $62 2024-03-01 Buy
Cayman Chemical 16297 WZ4002 ≥98% 10mg $109 2024-03-01 Buy
Cayman Chemical 16297 WZ4002 ≥98% 50mg $419 2024-03-01 Buy

Properties

Density :1.314
storage temp. :Store at -20°C
solubility :≥24.7 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :solid
pka :12.78±0.70(Predicted)
color :Light yellow to yellow

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

The recurrent missense mutation T790M in the kinase domain of epidermal growth factor receptor (EGFR) is a gatekeeper mutation, as it sterically hinders binding of inhibitors while preserving catalytic activity. WZ4002 is an irreversible EGFR tyrosine kinase inhibitor that blocks ATP-dependent autophosphorylation of EGFR carrying the T790M mutation as well as an L858R mutation (IC50 = 8 nM). It preferentially targets cells expressing EGFRT790M over those expressing EGFR without the T790M mutation. WZ4002 is also bioavailable in vivo when given intravenously and is effective in mouse models of lung cancer driven by EGFRT790M. Efficacy may be enhanced when used in combination therapy with inhibitors of Met kinase activity, Bcl-2, or histone deacetylases.

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