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ChemicalBook >> CAS DataBase List >> UNC-0642

UNC-0642

UNC-0642 price.
  • $36 - $1946
  • Product name: UNC-0642
  • CAS: 1481677-78-4
  • MF: C29H44F2N6O2
  • MW: 546.7
  • EINECS:
  • MDL Number:MFCD28044322
  • Synonyms:UNC 0642;UNC0642;UNC-0642;2-(4,4-Difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine;UNC0642, 2-(4,4-Difluoro-1-piperidinyl)-6-Methoxy-N-[1-(1-Methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinaMine;2-(4,4-Difluoropiperidin-1-yl)-6-methoxy-N-[1-(propan-2-yl)piperidin-4-yl]-7-[3-(pyrrolidin-1-yl)propoxy]quinazolin-4-amine;2-(4,4-difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine;UNC-0642;UNC0642;UNC 0642
30 prices
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Brand
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • Tocris
  • TRC
Package
  • 10
  • 1mg
  • 5mg
  • 10mM(in 1mL DMSO)
  • 10mg
  • 25mg
  • 50mg
  • 50
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product numberSYN5374
  • Product descriptionUNC0642
  • Packaging50mg
  • Price$617
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA464128
  • Product description2-(4,4-Difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98+%
  • Packaging1mg
  • Price$36
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA464128
  • Product description2-(4,4-Difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98+%
  • Packaging5mg
  • Price$69
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA464128
  • Product description2-(4,4-Difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98+%
  • Packaging10mg
  • Price$137
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA464128
  • Product description2-(4,4-Difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98+%
  • Packaging25mg
  • Price$272
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA464128
  • Product description2-(4,4-Difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98+%
  • Packaging50mg
  • Price$355
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA464128
  • Product description2-(4,4-Difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98+%
  • Packaging100mg
  • Price$517
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA464128
  • Product description2-(4,4-Difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98+%
  • Packaging250mg
  • Price$865
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA464128
  • Product description2-(4,4-Difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98+%
  • Packaging1g
  • Price$1946
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7757
  • Product descriptionUNC0642
  • Packaging10mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7757
  • Product descriptionUNC0642
  • Packaging10mM(in 1mL DMSO)
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7757
  • Product descriptionUNC0642
  • Packaging50mg
  • Price$380
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number14604
  • Product descriptionUNC0642 ≥95%
  • Packaging1mg
  • Price$62
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14604
  • Product descriptionUNC0642 ≥95%
  • Packaging5mg
  • Price$180
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14604
  • Product descriptionUNC0642 ≥95%
  • Packaging10mg
  • Price$270
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM142730
  • Product description2-(4,4-difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98%
  • Packaging100mg
  • Price$763
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific SYN5374 UNC0642 50mg $617 2021-12-16 Buy
Ambeed A464128 2-(4,4-Difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98+% 1mg $36 2021-12-16 Buy
Ambeed A464128 2-(4,4-Difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98+% 5mg $69 2021-12-16 Buy
Ambeed A464128 2-(4,4-Difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98+% 10mg $137 2021-12-16 Buy
Ambeed A464128 2-(4,4-Difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98+% 25mg $272 2021-12-16 Buy
Ambeed A464128 2-(4,4-Difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98+% 50mg $355 2021-12-16 Buy
Ambeed A464128 2-(4,4-Difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98+% 100mg $517 2021-12-16 Buy
Ambeed A464128 2-(4,4-Difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98+% 250mg $865 2021-12-16 Buy
Ambeed A464128 2-(4,4-Difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98+% 1g $1946 2021-12-16 Buy
ApexBio Technology B7757 UNC0642 10mg $120 2021-12-16 Buy
ApexBio Technology B7757 UNC0642 10mM(in 1mL DMSO) $120 2021-12-16 Buy
ApexBio Technology B7757 UNC0642 50mg $380 2021-12-16 Buy
Cayman Chemical 14604 UNC0642 ≥95% 1mg $62 2024-03-01 Buy
Cayman Chemical 14604 UNC0642 ≥95% 5mg $180 2024-03-01 Buy
Cayman Chemical 14604 UNC0642 ≥95% 10mg $270 2024-03-01 Buy
Chemenu CM142730 2-(4,4-difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98% 100mg $763 2021-12-16 Buy

Properties

Boiling point :679.2±65.0 °C(Predicted)
Density :1.23±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
pka :10.06±0.20(Predicted)
form :powder
color :white to beige

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferases G9a and G9a-like protein (GLP) can mono- or dimethylate lysine 9 on histone 3, contributing to early embryogenesis, genomic imprinting, and lymphocyte development. UNC0642 is a selective inhibitor of G9a and GLP that competitively inhibits binding of H3K9 substrates with a Ki = 3.7 nM. It exhibits >2,000-fold selectivity over the lysine methyltransferase EZH2 and >20,000-fold selectivity over other methyltransferases. UNC0642 has been shown to reduce H3K9 dimethylation levels in MDA-MB-231 and PANC-1 cells with IC50 values of 110 and 40 nM, respectively. Furthermore, it displays improved pharmacokinetic properties relative to UNC0638 . See the Structural Genomics Consortium (SGC) website for more information.

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