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ChemicalBook >> CAS DataBase List >> UNC3230

UNC3230

UNC3230 price.
  • $48 - $982
  • Product name: UNC3230
  • CAS: 1031602-63-7
  • MF: C17H20N4O2S
  • MW: 344.43
  • EINECS:
  • MDL Number:MFCD15031190
  • Synonyms:UNC3230;2-anilino-5-(cyclohexanecarbonylamino)-1,3-thiazole-4-carboxamide;5-[(Cyclohexylcarbonyl)amino]-2-(phenylamino)-thiazolecarboxamide;4-Thiazolecarboxamide, 5-[(cyclohexylcarbonyl)amino]-2-(phenylamino)-;5-(Cyclohexanecarboxamido)-2-(phenylamino)thiazole-4-carboxamide;hyperalgesia,thermal,UNC3230,DRG,antinociceptive,neuron,inhibit,UNC-3230,PIP2,anticancer,glycolysis,PIP4K2C,PIP5K1C,Inhibitor
19 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Biosynth Carbosynth
  • Cayman Chemical
  • Tocris
  • TRC
  • Usbiological
Package
  • 10
  • 5mg
  • 10mg
  • 50
  • 1mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • ManufacturerAK Scientific
  • Product number4840DG
  • Product description2-Anilino-5-(cyclohexanecarbonylamino)-1,3-thiazole-4-carboxamide
  • Packaging100mg
  • Price$455
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1195872
  • Product description5-(Cyclohexanecarboxamido)-2-(phenylamino)thiazole-4-carboxamide 98%
  • Packaging25mg
  • Price$226
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1195872
  • Product description5-(Cyclohexanecarboxamido)-2-(phenylamino)thiazole-4-carboxamide 98%
  • Packaging50mg
  • Price$340
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1195872
  • Product description5-(Cyclohexanecarboxamido)-2-(phenylamino)thiazole-4-carboxamide 98%
  • Packaging100mg
  • Price$513
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1195872
  • Product description5-(Cyclohexanecarboxamido)-2-(phenylamino)thiazole-4-carboxamide 98%
  • Packaging250mg
  • Price$885
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4941
  • Product descriptionUNC3230
  • Packaging50mg
  • Price$982
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC166267
  • Product descriptionUNC 3230
  • Packaging10mg
  • Price$95
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC166267
  • Product descriptionUNC 3230
  • Packaging25mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC166267
  • Product descriptionUNC 3230
  • Packaging50mg
  • Price$225
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC166267
  • Product descriptionUNC 3230
  • Packaging100mg
  • Price$300
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC166267
  • Product descriptionUNC 3230
  • Packaging250mg
  • Price$550
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16401
  • Product descriptionUNC3230 ≥95%
  • Packaging50mg
  • Price$807
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16401
  • Product descriptionUNC3230 ≥95%
  • Packaging10mg
  • Price$210
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16401
  • Product descriptionUNC3230 ≥95%
  • Packaging5mg
  • Price$117
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16401
  • Product descriptionUNC3230 ≥95%
  • Packaging1mg
  • Price$48
  • Updated2024-03-01
  • Buy
  • ManufacturerTocris
  • Product number5271
  • Product descriptionUNC3230 ≥99%(HPLC)
  • Packaging10
  • Price$208
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 4840DG 2-Anilino-5-(cyclohexanecarbonylamino)-1,3-thiazole-4-carboxamide 100mg $455 2021-12-16 Buy
Ambeed A1195872 5-(Cyclohexanecarboxamido)-2-(phenylamino)thiazole-4-carboxamide 98% 25mg $226 2021-12-16 Buy
Ambeed A1195872 5-(Cyclohexanecarboxamido)-2-(phenylamino)thiazole-4-carboxamide 98% 50mg $340 2021-12-16 Buy
Ambeed A1195872 5-(Cyclohexanecarboxamido)-2-(phenylamino)thiazole-4-carboxamide 98% 100mg $513 2021-12-16 Buy
Ambeed A1195872 5-(Cyclohexanecarboxamido)-2-(phenylamino)thiazole-4-carboxamide 98% 250mg $885 2021-12-16 Buy
ApexBio Technology B4941 UNC3230 50mg $982 2021-12-16 Buy
Biosynth Carbosynth FC166267 UNC 3230 10mg $95 2021-12-16 Buy
Biosynth Carbosynth FC166267 UNC 3230 25mg $150 2021-12-16 Buy
Biosynth Carbosynth FC166267 UNC 3230 50mg $225 2021-12-16 Buy
Biosynth Carbosynth FC166267 UNC 3230 100mg $300 2021-12-16 Buy
Biosynth Carbosynth FC166267 UNC 3230 250mg $550 2021-12-16 Buy
Cayman Chemical 16401 UNC3230 ≥95% 50mg $807 2024-03-01 Buy
Cayman Chemical 16401 UNC3230 ≥95% 10mg $210 2024-03-01 Buy
Cayman Chemical 16401 UNC3230 ≥95% 5mg $117 2024-03-01 Buy
Cayman Chemical 16401 UNC3230 ≥95% 1mg $48 2024-03-01 Buy
Tocris 5271 UNC3230 ≥99%(HPLC) 10 $208 2021-12-16 Buy

Properties

storage temp. :Store at -20°C
solubility :DMSO:30.0(Max Conc. mg/mL);87.1(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);87.1(Max Conc. mM)
Ethanol:0.2(Max Conc. mg/mL);0.58(Max Conc. mM) form :A crystalline solid
color :Off-white to light yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330 Rinse mouth.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Phosphatidylinositol-4-phosphate 5-kinase type-1 γ (PIP5K1C) is a lipid kinase that generates phosphatidylinositol-4,5-bisphosphate (PIP2) in nociceptive dorsal root ganglia (DRG). Pain sensitization is regulated by multiple signaling pathways that are initiated by phospholipase C-mediated hydrolysis of PIP2. UNC3230 is a small molecule inhibitor of PIP5K1C (IC50 = 41 nM, Kd = 51 nM). It does not inhibit any other lipid kinases that regulate phosphoinositide levels, including phosphatidylinositol 3-kinases. At 100 nM, UNC3230 decreases PIP2 membrane levels in cultured DRG neurons by 45% and significantly reduces calcium signaling. At 2 nM, it displays antinociceptive effects in mouse models of chronic pain when administered intrathecally or injected into inflamed hindpaw.

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