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ChemicalBook >> CAS DataBase List >> SIRAMESINE

SIRAMESINE

SIRAMESINE price.
  • $163 - $3728.1
  • Product name: SIRAMESINE
  • CAS: 147817-50-3
  • MF: C30H31FN2O
  • MW: 454.58
  • EINECS:
  • MDL Number:MFCD00912182
  • Synonyms:SIRAMESINE;1'-(4-(1-(4-fluorophenyl)-1H-indol-3-yl)butyl)-3H-spiro[isobenzofuran-1,4'-piperidine];1'-(4-(1-(4-FLUOROPHENYL)-1H-INDOL-3-YL)BUTYL)-3H-SPIRO[ISOBENZOFURAN-1,4'-PIPERIDINE].HCL;1'-[4-[1-(4-Fluorophenyl)-1H-indol-3-yl]-1-butyl]spiro[isobenzofuran-1(3H),4'-piperidine];1'-[4-[1-(4-fluorophenyl)indol-3-yl]butyl]spiro[1H-2-benzofuran-3,4'-piperidine];CS-1476;Spiro[isobenzofuran-1(3H),4'-piperidine], 1'-[4-[1-(4-fluorophenyl)-1H-indol-3-yl]butyl]-;1'-(4-(1-(4-fluorophenyl)-1H-indol-3-yl)butyl)-3H-spiro[isobenzofuran-1,4'-piperidine
19 prices
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Brand
  • ApexBio Technology
  • Biorbyt Ltd
  • Chemenu
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Matrix Scientific
Package
  • 2mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • 1000mg
  • ManufacturerApexBio Technology
  • Product numberB1297
  • Product descriptionSiramesine
  • Packaging5mg
  • Price$258
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1297
  • Product descriptionSiramesine
  • Packaging10mg
  • Price$391
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1297
  • Product descriptionSiramesine
  • Packaging25mg
  • Price$567
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1297
  • Product descriptionSiramesine
  • Packaging50mg
  • Price$927
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1297
  • Product descriptionSiramesine
  • Packaging100mg
  • Price$1441
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181320
  • Product descriptionSiramesine >98%
  • Packaging100mg
  • Price$950.3
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181320
  • Product descriptionSiramesine >98%
  • Packaging250mg
  • Price$1876.8
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181320
  • Product descriptionSiramesine >98%
  • Packaging1000mg
  • Price$3728.1
  • Updated2021-12-16
  • Buy
  • ManufacturerChemenu
  • Product numberCM139634
  • Product descriptionSiramesine(Lu28-179) 98%
  • Packaging100mg
  • Price$852
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003380
  • Product descriptionSiramesine(Lu28-179) 98+%
  • Packaging5mg
  • Price$163
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003380
  • Product descriptionSiramesine(Lu28-179) 98+%
  • Packaging10mg
  • Price$247
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003380
  • Product descriptionSiramesine(Lu28-179) 98+%
  • Packaging50mg
  • Price$586
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003380
  • Product descriptionSiramesine(Lu28-179) 98+%
  • Packaging100mg
  • Price$911
  • Updated2021-12-16
  • Buy
  • ManufacturerCSNpharm
  • Product numberCSN16114
  • Product descriptionSiramesine
  • Packaging2mg
  • Price$170
  • Updated2021-12-16
  • Buy
  • ManufacturerCSNpharm
  • Product numberCSN16114
  • Product descriptionSiramesine
  • Packaging50mg
  • Price$918
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC7499
  • Product descriptionSiramesine >98%
  • Packaging250mg
  • Price$1250
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
ApexBio Technology B1297 Siramesine 5mg $258 2021-12-16 Buy
ApexBio Technology B1297 Siramesine 10mg $391 2021-12-16 Buy
ApexBio Technology B1297 Siramesine 25mg $567 2021-12-16 Buy
ApexBio Technology B1297 Siramesine 50mg $927 2021-12-16 Buy
ApexBio Technology B1297 Siramesine 100mg $1441 2021-12-16 Buy
Biorbyt Ltd orb181320 Siramesine >98% 100mg $950.3 2021-12-16 Buy
Biorbyt Ltd orb181320 Siramesine >98% 250mg $1876.8 2021-12-16 Buy
Biorbyt Ltd orb181320 Siramesine >98% 1000mg $3728.1 2021-12-16 Buy
Chemenu CM139634 Siramesine(Lu28-179) 98% 100mg $852 2021-12-16 Buy
Crysdot CD31003380 Siramesine(Lu28-179) 98+% 5mg $163 2021-12-16 Buy
Crysdot CD31003380 Siramesine(Lu28-179) 98+% 10mg $247 2021-12-16 Buy
Crysdot CD31003380 Siramesine(Lu28-179) 98+% 50mg $586 2021-12-16 Buy
Crysdot CD31003380 Siramesine(Lu28-179) 98+% 100mg $911 2021-12-16 Buy
CSNpharm CSN16114 Siramesine 2mg $170 2021-12-16 Buy
CSNpharm CSN16114 Siramesine 50mg $918 2021-12-16 Buy
DC Chemicals DC7499 Siramesine >98% 250mg $1250 2021-12-16 Buy

Properties

Boiling point :611.4±55.0 °C(Predicted)
Density :1.19±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,Room Temperature
solubility :Soluble in DMSO (up to at least 25 mg/ml)
form :solid
pka :9.45±0.20(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Siramesine (Lu 28-179, 147817-50-3) is a σ2 selective agonist?(IC50’s: σ1 = 17nM, σ2 = 0.2nM).1?It produced non-sedating potent and long-last anxiolytic effects in rodents.2?Siramesine induced caspase-independent programmed cell death in various cancer cell lines?via?increased levels of ROS and lysosomal leakage.3,4,5?Mitochondrial destabilization via loss of membrane potential and increased ROS has also been offered as a mechanism of action for the triggering of cell death by Siramesine.6

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