JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
Tel: +1-832-696-8203
Email: [email protected]
Worldwide Distributors
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Siramesine（Lu 28-179）is a specific agonist of sigma (σ) receptor [1].
Siramesine（Lu 28-179）has been reported to specific bind to σ2 receptor in human cortical and rat brain homogenates with Kd values of 1.1±0.2nM, 2.2 ±0.4nM and moderate capacity Bmax values of 26±3 fmol mg tissue-1,50±12 fmol mg tissue-1, respectively. In addition, Siramesine has shown the ligand selectivity profile of [3H]Lu28-179 binding to rat and human brain membranes with Ki values of 4.4±1.7nM and 8.6±0.6 nM, respectively. Apart from these, Siramesine has been revealed to displace [3H]DTG binding with very high affinity and [3H](+)pentazocine binding of σ2-sites. The IC50 of Siramesine inhibited the [3H]DTG binding is 0.19nM [1].
References:[1] S?by KK1, Mikkelsen JD, Meier E, Thomsen C. Lu 28-179 labels a sigma(2)-site in rat and human brain. Neuropharmacology. 2002 Jul;43(1):95-100.
