SAfit2
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- $130 - $2085
- Product name: SAfit2
- CAS: 1643125-33-0
- MF: C46H62N2O10
- MW: 802.99
- EINECS:
- MDL Number:MFCD31619236
- Synonyms:SAfit2;2-Piperidinecarboxylic acid, 1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl]-, (1R)-3-(3,4-dimethoxyphenyl)-1-[3-[2-(4-morpholinyl)ethoxy]phenyl]propyl ester, (2S)-;(R)-3-(3,4-Dimethoxyphenyl)-1-(3-(2-morpholinoethoxy)phenyl)propyl (S)-1-((S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl)piperidine-2-carboxylate;(1R)-3-(3,4-dimethoxyphenyl)-1-{3-[2-(morpholin-4-yl)ethoxy]phenyl}propyl (2S)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxylate;SAFit2, 10 mM in DMSO
8 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- ChemScene
- TRC
Package
- 500μg
- 1mg
- 5mg
- 10mg
- 25mg
- ManufacturerAK Scientific
- Product number5023EA
- Product descriptionSAFit2
- Packaging1mg
- Price$353
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number24366
- Product descriptionSAfit2 ≥95%
- Packaging500μg
- Price$130
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number24366
- Product descriptionSAfit2 ≥95%
- Packaging1mg
- Price$243
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number24366
- Product descriptionSAfit2 ≥95%
- Packaging5mg
- Price$830
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0022959
- Product descriptionSAFit2 98.59%
- Packaging5mg
- Price$290
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0022959
- Product descriptionSAFit2 98.59%
- Packaging10mg
- Price$480
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0022959
- Product descriptionSAFit2 98.59%
- Packaging25mg
- Price$1050
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberS139585
- Product descriptionSAFit2
- Packaging5mg
- Price$2085
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 5023EA | SAFit2 | 1mg | $353 | 2021-12-16 | Buy |
| Cayman Chemical | 24366 | SAfit2 ≥95% | 500μg | $130 | 2024-03-01 | Buy |
| Cayman Chemical | 24366 | SAfit2 ≥95% | 1mg | $243 | 2024-03-01 | Buy |
| Cayman Chemical | 24366 | SAfit2 ≥95% | 5mg | $830 | 2024-03-01 | Buy |
| ChemScene | CS-0022959 | SAFit2 98.59% | 5mg | $290 | 2021-12-16 | Buy |
| ChemScene | CS-0022959 | SAFit2 98.59% | 10mg | $480 | 2021-12-16 | Buy |
| ChemScene | CS-0022959 | SAFit2 98.59% | 25mg | $1050 | 2021-12-16 | Buy |
| TRC | S139585 | SAFit2 | 5mg | $2085 | 2021-12-16 | Buy |
Properties
Boiling point :877.0±65.0 °C(Predicted)
Density :1.168±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml
form :A crystalline solid
pka :6.43±0.10(Predicted)
color :Off-white to pink
Density :1.168±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml
form :A crystalline solid
pka :6.43±0.10(Predicted)
color :Off-white to pink
Safety Information
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Description
SAfit2 is a potent inhibitor of FK506-binding protein 51 (FKBP51; Ki = 6 nM). It is highly selective for FKBP51 over FKBP52 (Ki = >50,000 nM) and has increased brain permeability in comparison to SAfit1. SAfit2 (20 mg/kg) enhances HPA axis suppression in mice by decreasing plasma corticosterone levels to a greater extent than in control mice following dexamethasone administration. It also does not increase plasma corticosterone levels as high as in control mice following subsequent administration of corticotropin-releasing factor (CRF; ). It decreases the time spent immobile in the forced swim test and increases the time spent in the open arms of the elevated plus maze, indicating antidepressant-like and anxiolytic-like activity, respectfully.Suppliers and manufacturers
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
Jilin Chinese Academy of Sciences-yanshen Technology
ShangHai Caerulum Pharma Discovery Co., Ltd.
Shanghai EFE Biological Technology Co., Ltd.
Shanghai Han-Xiang Chemical Co., Ltd.
Fan De(Beijing) Biotechnology Co., Ltd.
Henan Alpha Chemical Co., Ltd.
Jilin Province Woda Biotechnology Co., Ltd.
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
