Product Details
Product Name:
SAFit2 |
CAS No.:
1643125-33-0 |
Purity:
99.96% |
Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
Name | SAFit2 |
Description | SAFit2 is a highly potent and selective inhibitor of fk506 binding protein 51 (FKBP51) with a Ki value of 6 nM. SAFit2 can enhance the binding of AKT2-AS160 and participate in the downstream response of glucocorticoid release in vivo. It is a candidate compound for the treatment of obesity, chronic pain, depression and anxiety. |
In vitro | METHODS: The effects of SAFit2 (1, 5, 10 μM) on macrophage migration were evaluated in a Transwell assay.
RESULTS SAFit2 significantly reduced macrophage migration in a concentration-dependent manner. [4] |
In vivo | METHODS: SAFit2 (20 mg/kg, intraperitoneal injection, twice a day, 10 days) was administered to mice and glucose tolerance was observed.
RESULTS SAFit2 treatment significantly improved glucose tolerance. [1] |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 90.0 mg/mL (112.1 mM), Sonication is recommended.
|
Keywords | SAFit2 | SAFit-2 |
Inhibitors Related | FKBP51F67V-selective antagonist Ligand2 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
-
CAS:92284-99-6
$243.00 / 1mg
-
CAS:6850-30-2
$218.00 / 1mg
-
CAS:2414572-47-5
$34.00 / 2mg
Recommended supplier
Product name |
Price |
|
Suppliers |
Update time |
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |