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ChemicalBook >> CAS DataBase List >> Posaconazole

Posaconazole

Posaconazole price.
  • $6 - $2691.1
  • Product name: Posaconazole
  • CAS: 171228-49-2
  • MF: C37H42F2N8O4
  • MW: 700.78
  • EINECS:682-747-8
  • MDL Number:MFCD00941162
  • Synonyms:4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-((2S,3S)-2-hydroxypentan-3-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one;Posaconazole(Form Ⅲ);Posaconazole ;2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol;Sch 56592;HYDROXYPROPYL]-2,4-DIHYDRO-3H-1,2,4-TRIAZOL-3-ONE;Posaconazole for research;1-((1S,2S)-1-Ethyl-2-hydroxypropyl)-4-{4-[4-(4-{[(5S,3R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazolylmethyl)oxolan-3-yl]methoxy}phenyl)piperazinyl]phenyl}-1,2,4-triazolin-5-one
41 prices
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Brand
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Biorbyt Ltd
  • Cayman Chemical
  • Chem-Impex
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TCI Chemical
  • TRC
Package
  • 10mM(in 1mL DMSO)
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50MG
  • 100mg
  • 250mg
  • 1mL
  • 1g
  • 5g
  • 10g
  • 25g
  • 100g
  • ManufacturerAK Scientific
  • Product numberM842
  • Product descriptionPosaconazole
  • Packaging100mg
  • Price$395
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA133379
  • Product description4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3S)-2-hydroxypentan-3-yl)-1H-1,2,4-triazol-5(4H)-one 98+%
  • Packaging1g
  • Price$32
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA133379
  • Product description4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3S)-2-hydroxypentan-3-yl)-1H-1,2,4-triazol-5(4H)-one 98+%
  • Packaging5g
  • Price$115
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA133379
  • Product description4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3S)-2-hydroxypentan-3-yl)-1H-1,2,4-triazol-5(4H)-one 98+%
  • Packaging10g
  • Price$199
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA133379
  • Product description4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3S)-2-hydroxypentan-3-yl)-1H-1,2,4-triazol-5(4H)-one 98+%
  • Packaging25g
  • Price$395
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA133379
  • Product description4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3S)-2-hydroxypentan-3-yl)-1H-1,2,4-triazol-5(4H)-one 98+%
  • Packaging100g
  • Price$1470
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1718
  • Product descriptionPosaconazole
  • Packaging5mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1718
  • Product descriptionPosaconazole
  • Packaging10mM(in 1mL DMSO)
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1718
  • Product descriptionPosaconazole
  • Packaging25mg
  • Price$400
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1718
  • Product descriptionPosaconazole
  • Packaging100mg
  • Price$1000
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS003292
  • Product descriptionPosaconazole ≥98%
  • Packaging5mg
  • Price$6
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS003292
  • Product descriptionPosaconazole ≥98%
  • Packaging10mg
  • Price$8
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS003292
  • Product descriptionPosaconazole ≥98%
  • Packaging100mg
  • Price$23
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS003292
  • Product descriptionPosaconazole ≥98%
  • Packaging1g
  • Price$95
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60415
  • Product descriptionPosaconazole ≥98%
  • Packaging10mg
  • Price$238
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1557
  • Product descriptionPosaconazole-SCH56592|Noxafil 99%
  • Packaging5mg
  • Price$99
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific M842 Posaconazole 100mg $395 2021-12-16 Buy
Ambeed A133379 4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3S)-2-hydroxypentan-3-yl)-1H-1,2,4-triazol-5(4H)-one 98+% 1g $32 2021-12-16 Buy
Ambeed A133379 4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3S)-2-hydroxypentan-3-yl)-1H-1,2,4-triazol-5(4H)-one 98+% 5g $115 2021-12-16 Buy
Ambeed A133379 4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3S)-2-hydroxypentan-3-yl)-1H-1,2,4-triazol-5(4H)-one 98+% 10g $199 2021-12-16 Buy
Ambeed A133379 4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3S)-2-hydroxypentan-3-yl)-1H-1,2,4-triazol-5(4H)-one 98+% 25g $395 2021-12-16 Buy
Ambeed A133379 4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3S)-2-hydroxypentan-3-yl)-1H-1,2,4-triazol-5(4H)-one 98+% 100g $1470 2021-12-16 Buy
ApexBio Technology A1718 Posaconazole 5mg $80 2021-12-16 Buy
ApexBio Technology A1718 Posaconazole 10mM(in 1mL DMSO) $120 2021-12-16 Buy
ApexBio Technology A1718 Posaconazole 25mg $400 2021-12-16 Buy
ApexBio Technology A1718 Posaconazole 100mg $1000 2021-12-16 Buy
Arctom AS003292 Posaconazole ≥98% 5mg $6 2021-12-16 Buy
Arctom AS003292 Posaconazole ≥98% 10mg $8 2021-12-16 Buy
Arctom AS003292 Posaconazole ≥98% 100mg $23 2021-12-16 Buy
Arctom AS003292 Posaconazole ≥98% 1g $95 2021-12-16 Buy
Arctom CFN60415 Posaconazole ≥98% 10mg $238 2021-12-16 Buy
Axon Medchem Axon1557 Posaconazole-SCH56592|Noxafil 99% 5mg $99 2021-12-16 Buy

Properties

Melting point :170-1720C
Boiling point :850.7±75.0 °C(Predicted)
Density :1.36±0.1 g/cm3(Predicted)
Flash point :9℃
storage temp. :-20°C
solubility :Chloroform (Slightly), Methanol (Slightly)
pka :14.72±0.20(Predicted)
form :powder
color :white to beige
optical activity :[α]/D -24 to -32°, c = 1.0 in chloroform-d
Merck :14,7602
InChIKey :RAGOYPUPXAKGKH-XAKZXMRKSA-N
SMILES :[C@]1(OC[C@@H](COC2C=CC(N3CCN(C4=CC=C(N5C=NN([C@@H](CC)[C@@H](O)C)C5=O)C=C4)CC3)=CC=2)C1)(CN1N=CN=C1)C1=CC=C(F)C=C1F |&1:0,3,22,25,r|
CAS DataBase Reference :171228-49-2(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger GHS hazard pictograms P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P311 Call a POISON CENTER or doctor/physician.

Description

Posaconazole is a broad-spectrum triazole active against various yeasts and molds, including Aspergillus, Candida, Fusarium, and Zygomycetes. Posaconazole inhibits the growth of fungi by inhibiting the lanosterol 14α-demethylase enzyme (IC50s range from 7-200 nM), which results in a disruption the synthesis of ergosterol, a key sterol necessary for fungal cell membrane integrity and for the function of certain membrane-bound proteins.

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